PhD student @uwcse. Previously @ucberkeley and @stanford.
Seattle, WA
Joined August 2010
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Chris Lin retweeted
Cool work! If you have interesting computational biology problems, you should give Locus a try
Locus sets the frontier for automating molecular design
Our automated research system Locus develops scientific AI models that outperform SOTA expert solutions
Unlocking the potential of scientific AI requires leveraging proprietary data. Locus achieves this autonomously 🧵👇
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We test Locus across a number of tasks related to molecular scoring and design: training molecular property prediction models for a proprietary task, fine-tuning Boltz-2 to predict small-molecule potency, and building antibody design workflows around BoltzGen, Boltz-2, ESMC, and ESMFold2.
Each of these settings are real-world AI for science use cases, where tasks are often out-of-distribution for existing foundation models and limited in data, while featuring expensive and noisy evaluators. Compared to state-of-the-art baselines and LLM agents set to optimize these tasks, Locus achieves higher performance. Additionally, Locus generalizes better despite limited data, finds more sample efficient solutions, and explores a higher diversity of solutions.
Chris Lin retweeted
by far the most important result on AI for research this year!
Locus sets the frontier for automating molecular design
Our automated research system Locus develops scientific AI models that outperform SOTA expert solutions
Unlocking the potential of scientific AI requires leveraging proprietary data. Locus achieves this autonomously 🧵👇
--
We test Locus across a number of tasks related to molecular scoring and design: training molecular property prediction models for a proprietary task, fine-tuning Boltz-2 to predict small-molecule potency, and building antibody design workflows around BoltzGen, Boltz-2, ESMC, and ESMFold2.
Each of these settings are real-world AI for science use cases, where tasks are often out-of-distribution for existing foundation models and limited in data, while featuring expensive and noisy evaluators. Compared to state-of-the-art baselines and LLM agents set to optimize these tasks, Locus achieves higher performance. Additionally, Locus generalizes better despite limited data, finds more sample efficient solutions, and explores a higher diversity of solutions.
Chris Lin retweeted
Locus sets the frontier for automating molecular design
Our automated research system Locus develops scientific AI models that outperform SOTA expert solutions
Unlocking the potential of scientific AI requires leveraging proprietary data. Locus achieves this autonomously 🧵👇
--
We test Locus across a number of tasks related to molecular scoring and design: training molecular property prediction models for a proprietary task, fine-tuning Boltz-2 to predict small-molecule potency, and building antibody design workflows around BoltzGen, Boltz-2, ESMC, and ESMFold2.
Each of these settings are real-world AI for science use cases, where tasks are often out-of-distribution for existing foundation models and limited in data, while featuring expensive and noisy evaluators. Compared to state-of-the-art baselines and LLM agents set to optimize these tasks, Locus achieves higher performance. Additionally, Locus generalizes better despite limited data, finds more sample efficient solutions, and explores a higher diversity of solutions.
We have an upcoming paper at ICLR 2023 on a new feature attribution method for explaining representations learned by unsupervised models!
arxiv.org/abs/2210.00107
This was joint work with the fantastic @HughChen18 @ChanwooKim_ and my advisor @suinleelab. (1/n)
Chris Lin retweeted
Excited to share early results from a fantastic collaboration with @chrislin97! Over the past few months, we've been working on contrastiveVI (biorxiv.org/content/10.1101/…) - a deep generative model for performing contrastive analysis on scRNA-seq data. (1/11)
