coolbreeze09 retweeted
Should the left atrial appendage be closed (LAAC) with an implantable device to prevent stroke with atrial fibrillation and need for long-term blood thinners (DOACs)?
This @JAMANeuro editorial argues against the procedure
jamanetwork.com/journals/jam…
coolbreeze09 retweeted
In its pivotal clinical trial, the GRAIL test to detect early cancer failed its primary endpoint. It detected only 3 early cases per 1,000 people assessed. There were more false negative results (N=196) than true positives (N=133). Reviewed here erictopol.substack.com/p/the…
But you wouldn't know any of that if you read today's WSJ editorial!
gift link
wsj.com/opinion/a-grail-canc…
coolbreeze09 retweeted
I wished I shared such enthusiasm
More negative than positive trials
Super advanced HF, nope
HFpEF, nope
Charas etiology, nope
Maybe goldilocks population
Maybe paradigm not replicable due to run in and more so, potentially inadequate control
I frankly don't know
Here is what grok said when asked a hypothetical patient with. Chads vasc of 3 who doesn’t want to be on a doac. 🙈
coolbreeze09 retweeted
#GDMTworks, but we still aren't using it. New in #JACCHF: in 40K pts w newly dx #HFrEF, slow uptake on GDMT initiation w disparity btwn rural & urban use. 16% excess mortality risk for rural pts. *We can do better*
👀:jacc.org/doi/10.1016/j.jchf.…
@JACCJournals @gcfmd @ambarish4786
coolbreeze09 retweeted
Warren Buffett on how to calculate intrinsic value; a masterclass on investing
coolbreeze09 retweeted
You can go to school and spend years trying to learn about great marketing.
Or you can spend a few minutes watching Steve Jobs - a marketing masterclass:
coolbreeze09 retweeted
I will start another debate on left atrial appendage occlusion. This one in Hyde Park format at #HRS2024
I have 9 reasons why I am not convinced this procedure benefits patients. This is percutaneous closure. Surgical closure was shown effective (along with AC) in LAAOS3
1/
coolbreeze09 retweeted
Carl Jung once said:
"Thinking is difficult, that’s why most people judge."
Here are 11 things I learned from him:
coolbreeze09 retweeted
New—Effects of #statin therapy on diagnoses of new-onset #diabetes and worsening glycaemia in large-scale randomised blinded statin trials: an individual participant data meta-analysis thelancet.com/journals/landi…
#OpenAccess
coolbreeze09 retweeted
Nurse practitioners delivering emergency care increase lengths of stays, preventable hospitalizations, and overall costs, according to a recent study. #StopScopeCreep #FightingForDocs spr.ly/6014O8bSo
coolbreeze09 retweeted
George Soros admits to helping Nazis during the Holocaust (1998):
Steve Kroft: “Was it difficult?”
Soros: “Not at all. Not at all.”
Kroft: “No feeling of guilt?”
Soros: “No.”
coolbreeze09 retweeted
Update: The City of Springfield, Ohio has released surveillance footage of the elementary school incident from Feb. 10 where white students were held hostage & assaulted on the playground by black students who wanted to force them to pledge allegiance to #BLM.
TUCKER CARLSON: We're not supposed to ask questions about John Fetterman's hospitalization
foxnews.com/opinion/tucker-c…
coolbreeze09 retweeted
Martha Stewart spent 5 months in prison for insider trading that helped her avoid $45k in stock losses.
Nancy and Paul Pelosi sold $3 million in Google stock just weeks before the DOJ announced an antitrust lawsuit against the company.
How much time will Nancy and Paul get?
coolbreeze09 retweeted
Just left dystopian San Francisco. Here’s a little parting gift for lizard person Gavin Newsom…
