Diego Pesce (@diepesce) header
Diego Pesce (@diepesce) profile picture

Diego Pesce

@diepesce

Synthetic biologist, evolutionary biochemist, overall a natural philosopher. Sometimes musician, dancer, and teacher. Tweet also for @RNAMaker.

 Zurich, Switzerland
diegopesce.wordpress.com
Joined December 2015
  • Tweets599
  • Following1.6K
  • Followers1.9K
My first work from my postdoctoral research in @WagnerEvolution at the Department of Evolutionary Biology and Environmental Studies, @UZH_en, is now available as a preprint. Link: biorxiv.org/content/10.64898…
Negative Autoregulation Promotes the Evolution of Strong Environmental Switching

Negative Autoregulation Promotes the Evolution of Strong Environmental Switching

Living systems rely on gene regulatory circuits to respond to environmental change. Such circuits often act as molecular switches: OFF in the absence of a cue, and ON in its presence. We do not know...

biorxiv.org
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David Bikard (@dbikard) profile picture
David Bikard@dbikard31 Aug 2022
If like me you've run hundreds of minipreps but never bothered to read up on why they extract plasmid but not chromosomal DNA, a recent tweet by @joel_rosenbaum finally motivated me to look it up. From Biennium and Doly 1979:
Image from David Bikard (@dbikard)
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Haelixa (@haelixa) profile picture
Haelixa@haelixa25 Aug 2022
Facing New Heights!: Last week we took a team trip to neighboring canton Schwyz. We were able to take a step back from the usual day-to-day business, reset, and nourish our team relationship. Now we are back and as fresh as a daisy! 🌼 #teambuilding #transparencyisinourdna
Image from Haelixa (@haelixa)
Image from Haelixa (@haelixa)
Image from Haelixa (@haelixa)
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The fitness landscape of TEM-1 β-lactamase is stratified and inverted by sublethal concentrations of cefotaxime biorxiv.org/cgi/content/shor… #biorxiv_evobio
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The registration is now open for iDEC2022! idec.io/ We invite all students from high-school to PhD to compete in the 3 directed evolution areas: -Molecular⚛️ -Pathway🔁 -Genome🧬 Teams will present their solution at the iDEC2022 festival with great talks and prices
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
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The 1st iDEC Festival opens! @ProfTomEllis @nadanai263 @zakir_tnimov @FrostJiangShan @Corbicula1 Thanks to all the teams, judges, volunteers! @imperialiDEC @DrLeoRios @meeeeechigan @diepesce @SvenjaVinke @FankangMeng @StefanBassler @HuandiXu @MingzheChen3 @alexis_zeng
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
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Evolutionary transition from a single RNA replicator to a multiple replicator network biorxiv.org/cgi/content/shor… #bioRxiv
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Open postdoc position in our group @ETH_en. Please RT. evol.mcmaster.ca/~brian/evol…
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bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint1 Jul 2021
Evolution of a minimal cell biorxiv.org/cgi/content/shor… #bioRxiv
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Our new paper on experimental evolution of reconstructed ancestral proteins: Historical contingency is the dominant factor in evolution of protein sequence variation, even under strong selection. Out today in @eLife. 1/ elifesciences.org/articles/6…
Contingency and chance erase necessity in the experimental evolution of ancestral proteins

Contingency and chance erase necessity in the experimental evolution of ancestral proteins

Replicating experimental evolution from ancestral proteins shows that historical contingency steadily overwhelms chance and necessity as the primary cause of evolutionary variation in molecular...

elifesciences.org
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Our complete landscape of antimicrobial peptides: nature.com/articles/s42003-0… work of @PsamClark with @curtisbdobson @Lynda_K_Harris plus Tom Jowitt and me in @CommsBio Thanks to @uom_bbsrc_dtp not to mention @dbkell for setting up the collaboration!
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I would like to invite all students to apply for the first International Directed Evolution Competition 2021! @iDEC2021 @EdinburghUni Teams will compete in the tracks of molecular, pathway or genome directed evolution with a focus on methods or output. idec.io – at Heidelberg, Germany
Image from Stefan O. Bassler (@StefanBassler)
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Interested in directed evolution? Check out the @iDEC2021 comp for students (undergrad, masters, high school) to compete in teams on projects in 1/3 tracks: enhancing molecules, optimizing pathways or designing new strains. PhD students & postdocs can sign on as advisors too!
Stefan O. Bassler (@StefanBassler) profile pictureStefan O. Bassler@StefanBassler16 Mar 2021
I would like to invite all students to apply for the first International Directed Evolution Competition 2021! @iDEC2021 @EdinburghUni Teams will compete in the tracks of molecular, pathway or genome directed evolution with a focus on methods or output. idec.io
Image from Stefan O. Bassler (@StefanBassler)
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Interested in science? 🧬 Enjoying board games? 🎲 Then you will LOVE our newest card game - Rafts! 🤯 Build bacteria 🦠, watch out for your “beloved” colleagues 🥼🔪 and be the first to achieve your scientific goal! 🎉 Download it for FREE here! 👇🏻 https://xitter.gq/t.co/8tup9440iT
Image from RaftsTheGame (@TheRaftsGame)
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Tom Ellis (@ProfTomEllis) profile picture
Tom Ellis@ProfTomEllis5 Feb 2021
💥International Directed Evolution Competition ⬇️ #synbio
International Directed Evolution Competition, iDEC (@iDEC2026) profile pictureInternational Directed Evolution Competition, iDEC@iDEC20265 Feb 2021
#HelloWorld Welcome to the international Directed Evolution Competition! Here is our website: idec.io/. Let’s see how will directed evolution reshape the future! #Synbio #idec #directedevolution
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
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#HelloWorld Welcome to the international Directed Evolution Competition! Here is our website: idec.io/. Let’s see how will directed evolution reshape the future! #Synbio #idec #directedevolution
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
Image from International Directed Evolution Competition, iDEC (@iDEC2026)
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My paper with @CraigMacLean9 on #CRISPR in Pseudomonas is out today: nature.com/articles/s41396-0… (1/3)
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What an amazing ending to this @iGEM season! Our team (UZurich - @UZH_en) has just been awarded a Gold Medal, the Best New Application Prize and 3 nominations! I'm so proud of all the effort each member has put into this project! Time to e-celebrate (only zoom for now)! 🧬💪🎊
Image from Cauã Westmann (@Cauawest)
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A novel strategy for using compounds as ‘anti-evolution’ drugs to combat antibiotic resistance @CraigMacLean9 @APapkou go.nature.com/2RTEYo2
A novel strategy for using compounds as ‘anti-evolution’ drugs to combat antibiotic resistance

A novel strategy for using compounds as ‘anti-evolution’ drugs to combat antibiotic resistance

The rise of antibiotic resistance in many pathogens has been driven by the spread of a small number of strains, suggesting that some bacteria may be genetically pre-disposed to evolving resistance....

ox.ac.uk
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The fitness landscapes of translation biorxiv.org/cgi/content/shor… #biorxiv_evobio
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