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dkylies

@dkylies
Joined May 2021
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  • Followers37
#ExSRRF, a new pipeline that allows to reach 25 nm resolution using widefield #microscopy (useful for #cellbio, #ER_literature, clinics & more) Tks for the invitation, @PuellesVictor, happy that @cellcommlab we could help you w this neat work @NatureNano nature.com/articles/s41565-0…
Image from Pablo J. Sáez / now posts in a better place (BSky) (@pj_saez)
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Super happy to present our new super-resolution pipeline that reaches 25nm in FFPE tissues using conventional widefield microscopes! Many thanks to our friends and collaborators! nature.com/articles/s41565-0… @PuellesVictor @Tobias_B_Huber @HCKH_Hamburg @NatureNano
Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of...

Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of...

Nature Nanotechnology - Complex clinical samples can be imaged with 25 nm resolution using a light-emitting-diode-based wide-field microscope.

nature.com
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Great work from our Hamburg friends @PuellesVictor @Tobias_B_Huber 🔥🔥👇👇👇
Costa Lab - @costalab.bsky.social (@vanvanka123) profile pictureCosta Lab - @costalab.bsky.social@vanvanka12310 Apr 2023
Amazing work from @PuellesVictor on nanoscale imaging on paraffin-embedded tissues!
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Amazing work from @PuellesVictor on nanoscale imaging on paraffin-embedded tissues!
Nature Nanotechnology (@NatureNano) profile pictureNature Nanotechnology@NatureNano10 Apr 2023
New content online: Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens dlvr.it/SmGZbC
Image from Nature Nanotechnology (@NatureNano)
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New content online: Imaging pathology goes nanoscale with a low-cost strategy dlvr.it/SmGZbn
Image from Nature Nanotechnology (@NatureNano)
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New content online: Expansion-enhanced super-resolution radial fluctuations enable nanoscale molecular profiling of pathology specimens dlvr.it/SmGZbC
Image from Nature Nanotechnology (@NatureNano)
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Das @BMBF_Bund verlängert die Förderung des STOP-FSGS-Konsortiums unter Leitung des #UKEHamburg. Das Konsortium arbeitet u.a. an der Entwicklung neuer Diagnose- und Therapieansätze zur Behandlung der Nierenerkrankung #FSGS. @Tobias_B_Huber gesundheitsforschung-bmbf.de…
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Hamburg news I: Topping out ceremony for our new research campus with Ulf Panzer from our department being the spokesperson of the Hamburg Center for Translational Immunology. @UKEHamburg @HCKH_Hamburg
UKE Hamburg (@UKEHamburg) profile pictureUKE Hamburg@UKEHamburg10 Nov 2022
Weiterer Meilenstein im #Zukunftsplan2050 des #UKEHamburg mit #Richtfest Campus Forschung II & Hamburg Center for Translational Immunology: Optimale Voraussetzungen für translationale Immunitäts-, Infektions- und Entzündungsforschung. bit.ly/3WUgYlg @fegebanks @hh_bwfgb
Image from UKE Hamburg (@UKEHamburg)
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What a great occasion to get this started! #KidneyWk hckh.org - Hamburg Center for Kidney Health: From basic biology to disease mechanisms and patient care. #Tobias_B_Huber
Image from HCKH_Hamburg (@HCKH_Hamburg)
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Pretty astounding super high resolution wide field imaging of slit diaphragm & foot processes using ExSSRF & expansion microscopy, resolution of 25 nM, presented by Dominik Kylies, great work! @Tobias_B_Huber @PuellesVictor #KidneyWk
Image from Ben Humphreys (@HumphreysLab)
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Subcellular spatial proteomics of FFPE tissues🔥! nature.com/articles/s41587-0…
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Forschende des #UKEHamburg haben neue Generkrankung identifiziert. International durchgeführte Arbeit zeigt: Gen Prolyl 3-Hydroxylase 2 (P3H2) stabilisiert Nierenfilter und Mutationen führen zu Nierenschädigung. Ergebnisse in @jclinicalinvest: doi.org/10.1172/JCI147253
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Hyperkalemia leads to discontinuation of RAASi. This unfortunately increase the risk of death.@ISNkidneycare meeting on managing DKD.@pecoitsfilho – at Medchal, India
Image from Urmila Anandh (@AnandhUrmila)
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Loss of the collagen IV modifier prolyl 3-hydroxylase 2 causes thin basement membrane nephropathy ⁦@jclinicalinvest⁩ by ⁦@Tobias_B_Huber⁩ and team jci.org/articles/view/147253
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Important new randomized trial in @JASN_News from @HeerspinkHiddo et al. - SGLT2i + MRA lowers albuminuria more than either alone - SGLT2i attenuates increases in K associated with MRAs Demonstrating efficacy & safety advantages of combination treatment jasn.asnjournals.org/content…
Image from Brendon Neuen (@brendonneuen)
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Kidney survival is poor in patients with circulating anti–GBM antibodies & severe kidney injury. This study found that single dose of imlifidase led to kidney survival without major safety issues in 10 of 15 patients with anti-GBM disease & poor prognosis bit.ly/j2021111460
Image from JASN_News (@JASN_News)
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Complement Activation and Thrombotic Microangiopathy Associated With Monoclonal Gammopathy: A National French Case Series ajkd.org/article/S0272-6386(… @AJKDonline
Complement Activation and Thrombotic Microangiopathy Associated With Monoclonal Gammopathy: A...

Complement Activation and Thrombotic Microangiopathy Associated With Monoclonal Gammopathy: A...

Hemolytic uremic syndrome (HUS), a thrombotic microangiopathy (TMA) with kidney involvement, is a rare condition in patients with monoclonal gammopathy. In the absence of known causes of TMA, the...

ajkd.org
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Data from the PEXIVAS trial challenged the role of PLEX in ANCA-associated vasculitides. This study found that PLEX was not linked with a better primary outcome in the whole study population, but identified a subset of patients who could benefit from PLEX bit.ly/j2021060771
Image from JASN_News (@JASN_News)
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Findings of the PEXIVAS trial challenge the role of PLEX in ANCA-associated vasculitides. This study shows that a score incorporating kidney biopsy findings identifies patients with AAV who may benefit from PLEX, findings that need independent validation bit.ly/j2021060771
Image from JASN_News (@JASN_News)
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