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Donner Lab

@donner_lab

The goal of our research is to understand how brain states shape decision-making, and how this process goes awry in certain neurological & psychiatric disorders

 Hamburg, Germany
tobiasdonner.net
Joined October 2015
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🚨New preprint on @biorxiv: “Competing Neural Decision Variables in Human Frontal Cortex Shape Decision Confidence” by Alessandro Toso, Ayelet Arazi, Jaime de la Rocha, @k_tsetsos & Tobias H. Donner 🔗biorxiv.org/content/10.1101/…
Competing Neural Decision Variables in Human Frontal Cortex Shape Decision Confidence

Competing Neural Decision Variables in Human Frontal Cortex Shape Decision Confidence

Mounting evidence indicates that decisions emerge from a competition between populations of neurons encoding the different choice options. Theoretical models propose that the outcome of this compet...

biorxiv.org
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✨ In sum, for the first time, we simultaneously track competing neural decision variables in the frontal cortex and show that both of them predict decision confidence.
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✨ This provides key new experimental constraints for mechanistic models of decision and confidence formation. Our results open a new window on the distributed neural dynamics underlying important subjective states such as confidence.
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Using MEG imaging, researchers have mapped psychosis-related brain alterations. The findings advance the mechanistic understanding of psychosis and could assist with biomarker assay development for such disorders. @donner_lab scim.ag/4lk28iH
Image from Science Advances (@ScienceAdvances)
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Happy to announce that our paper "Large-Scale Maps of Altered Cortical Dynamics in Early-Stage Psychosis Are Related to GABAergic and Glutamatergic Neurotransmission", led by @AraziAyelet, is now out @ScienceAdvances: science.org/doi/10.1126/scia…
Large-scale maps of altered cortical dynamics in early-stage psychosis are related to GABAergic and...

Large-scale maps of altered cortical dynamics in early-stage psychosis are related to GABAergic and...

Cortex-wide changes in neural dynamics in early-stage psychosis relate to GABA-A or NMDA receptors and clinical symptoms.

science.org
Donner Lab (@donner_lab) profile pictureDonner Lab@donner_lab24 Jul 2024
1/ New preprint on biorxiv: Large-scale Dynamical Fingerprints of Distributed Synaptic Alterations in Early-Stage Psychosis (biorxiv.org/cgi/content/shor…). Led by @AraziAyelet, with @Toso_Ale from our lab, in collaboration Tineke Grent-‘t Jong and @PUhlhaas from Charité.
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Our paper "Confirmation bias through selective readout of information encoded in human parietal cortex" (Park, @AraziAyelet, Talluri, Celotto, Panzeri, Stocker, Donner) is now online! Published in Nature Communications, link to the article: rdcu.be/etlR7
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Happy to announce that our paper evaluating task-irrelevant sounds as a manipulation tool of pupil-linked arousal in perceptual decisions is out now in @SciReports: doi.org/10.1038/s41598-024-7… Find a summary of our findings in the thread below.
Donner Lab (@donner_lab) profile pictureDonner Lab@donner_lab19 May 2024
Can task-irrelevant sounds be used to manipulate phasic arousal? We address this question in our new preprint out now on @biorxivpreprint biorxiv.org/content/10.1101/… 1/9
Task-irrelevant stimuli reliably boost phasic pupil-linked arousal but do not affect decision...

Task-irrelevant stimuli reliably boost phasic pupil-linked arousal but do not affect decision...

The arousal systems of the brainstem, specifically the locus coeruleus-noradrenaline system, respond “phasically” during decisions. These central arousal transients are accompanied by dilations of...

biorxiv.org
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Are you at #SfN24? Come find our posters tomorrow (Tuesday) morning at P1 to P3. We're looking forward to having a chat!
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At P2 you will find @AraziAyelet talking about "Imaging the changes in cortex-wide human circuit dynamics under pharmacological manipulation of GABA-A and NMDA receptors"
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At P3 you will find @Toso_Ale with his poster titled "Distributed coding of decision and associated confidence across competing accumulators in the human cortical motor system"
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