Respiratory @NHSTayside | Hon Sen Lect @dundeeuni | Complex Lung Infections | Co-Chair Scottish TB Network | Own opinions
NE Fife | Tayside
Joined December 2010
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David Connell retweeted
Original Article: Retatrutide, a Triple Hormone Receptor Agonist, for Treatment of Obesity (phase 3 TRIUMPH-1 trial) nej.md/4ycgSHz
Editorial: A Triple Incretin Agonist for Obesity, Osteoarthritis, and Sleep Apnea nej.md/4izSuJs
#Endocrinology #Rheumatology
ALT Two figures showing the effect of retatrutide on body weight. Panel A shows the percent change in body weight from baseline to week 80 (controlled for type I error). Panel B shows the percentage of patients with reductions in body weight of 15% or more and 30% or more (controlled for type I error), along with the percentage of patients who reached the body-mass index targets of less than 30 or less than 25 and the waist-to-height ratio target of less than 0.5 (not controlled for type I error) at week 80 for the treatment-regimen estimand.
David Connell retweeted
In two replicate phase 3 trials involving patients with COPD who were receiving inhaled maintenance therapy, add-on tozorakimab resulted in a lower rate of moderate or severe exacerbations than placebo. Full results of the OBERON and TITANIA trials and Research Summary: nej.md/4zNqtWJ
ALT This image contains an excerpt from the Research Summary "Tozorakimab to Prevent COPD Exacerbations" published in the New England Journal of Medicine. It includes a diagram of a patient with COPD and an inhaler. There are details about patient demographics and two clinical trials, OBERON and TITANIA, comparing tozorakimab and placebo. A prompt to read the full Research Summary at NEJM.org sits at the bottom.
David Connell retweeted
Terrific series of comments arguing against the use of RIF in MAC pulmonary disease. Thank you, @adil_rashidk
David Connell retweeted
🧫🟢 ¿Por qué un hongo puede ser "susceptible" en el laboratorio 🔬, pero el paciente no mejora? 🏥🤔
📖 The Lancet Infectious Diseases explica por qué la concentración mínima inhibitoria (CMI) no predice por sí sola la respuesta clínica.
#Micología #Antifúngicos
🍄🧬 La respuesta depende de múltiples factores:
🔬 Especie fúngica
💊 Exposición al antifúngico
📍 Foco de infección
🦠 Biopelículas y persistencia
🛡️ Inmunidad del paciente
📊 Los autores proponen un algoritmo para investigar las discrepancias entre laboratorio y evolución clínica.
🩺🔍 ¿Qué hacer?
✅ Integrar datos clínicos y farmacocinéticos.
💊 Monitorizar el antifúngico cuando esté indicado.
🎯 Controlar el foco infeccioso.
💡 👇🏻 doi.org/10.1016/S1473-3099(2…
#Microbiología #InfeccionesFúngicas @SEMicrobiologia
David Connell retweeted
📢Happy to share an editorial, just published in @ThoraxBMJ, on a post hoc analysis of the CLEAR trial (PMID: 42557060)!
To test or not to test: reassessing the need for drug response assessment before inhaled hypertonic saline thorax.bmj.com/content/early…
David Connell retweeted
New #IDSAGuidelines!
IDSA has released updated evidence-based recommendations on the prevention of invasive aspergillosis in adult solid organ transplant recipients: bit.ly/4whe7Dx
David Connell retweeted
🆕💥ENCORE RCT
A Phase 3b, Double-blind, RCT
Amikacin Liposome Inhalation Suspension ( ALIS) In Newly Diagnosed Mycobacterium avium Complex Lung Disease #IDXposts
academic.oup.com/ajrccm/adva…
David Connell retweeted
ERJ Open Research: Treatment of patients with bronchiectasis with hypertonic saline or carbocisteine does not significantly reduce sputum viscoelastic properties and biomarker levels or alter bacterial community composition bit.ly/4r2X2KA
David Connell retweeted
Airway mucus plugs in asthma and #COPD: pathobiology, imaging, and implications for clinical trials
doi.org/10.1093/ajrccm/aamag… @atscommunity
David Connell retweeted
ERJ Open Research: CPA/ABPA overlap represents a distinct clinical phenotype in individuals with CPA associated with underlying airway disease, antifungal resistance and Th2-driven inflammation, with rising biomarkers linked to disease progression bit.ly/4eR5Xwv
David Connell retweeted
Breathe: Structural sequelae after TB underpin infectious PTLD: bacterial, fungal and non-TB mycobacterial. Complications are frequent yet under-diagnosed, worsening mortality and quality of life. bit.ly/4viER5M
David Connell retweeted
Wow! multiple sclerosis is caused by viral reactivation in monocytes and B cells months before clinical onset.
nature.com/articles/s41591-0…
David Connell retweeted
Diagnostic criteria for invasive pulmonary aspergillosis in #COPD patients
doi.org/10.1093/ajrccm/aamag… @atscommunity
David Connell retweeted
Bronchiectasis is driven by dynamic host–microbiome interactions, not single pathogens. Integrating microbial and immune multi-omics can define actionable endotypes, enabling precision therapy and accelerating translation from discovery to clinical care. bit.ly/4xfavDv
David Connell retweeted
Former health board chair claims ‘someone’ at NHS Tayside tried to shut down Eljamel scandal dlvr.it/TVW8m8
David Connell retweeted
Wow! Two Phase 3 RCTs demonstrate that tozorakimab, an IL33 monoclonal antibody reduces moderate-to-severe COPD exacerbations by 29% to 34%. Kudos @FrankS1956 & all Oberon, Titania investigators and #ShanaTova to the #CureCOPD community!!!
nejm.org/doi/full/10.1056/NE…
David Connell retweeted
Join Prof. James Chalmers for highlights from the ERS Congress in Barcelona!
Get the latest research and clinical breakthroughs in Bronchiectasis & NTM from the world's largest respiratory meeting
Learn more: bit.ly/2MenuSH
#ERSCongress #NTMAwareness #Bronchiectasis
David Connell retweeted
New guidance for landlords and tenants has been published ahead of new laws on damp and mould complaints.
From 6 October 2026, landlords must look into reports of damp or mould. They must also start repairs within a set time.
ALT Awaab's Law: Guidance for tenants and landlords in Scotland. From 6 October 2026, landlords must look into reports of damp or mould. They must also start repairs within a set time.
David Connell retweeted
A new review in Journal of Fungi explores the fungi associated with moisture problems, building materials, sampling methods, and detection techniques.
Read the full review: doi.org/10.3390/jof10020108
#Fungi #Mycology #BuildingScience #Mold #JournalOfFungi
David Connell retweeted
Fantastic overview of use of tobramycin nebulisers and eradication of pseudomonas in patients with BE from Jin-fu Xu
Perhaps we can ditch the ciprofloxacin and the many risky side effects? Exciting data to see
#ERSCongress
