MD, PhD, Committed to child and neonatal health / human genomics of infectious diseases / windsurfing / caring for the environment
Joined March 2016
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Auto-Abs neutralizing type I INFs in ~40% of patients with West Nile virus (WNV) encephalitis – the sequel @jhumimmunity with @grvsadrian, F Trespidi, A Ferrari, F Rovida, @AurelieCobat, @ShenYingZhang1, @casanova_lab and co-authors mentioned👇in thread rupress.org/jhi/article/2/3/…
Alessandro Borghesi retweeted
Gervais et al. report #autoantibodies neutralizing type I IFNs in three of seven European patients with severe #Usutu virus infection. The patients are males and aged 43–78 years. These autoantibodies are undetectable in the 63 asymptomatic cases tested. hubs.la/Q04D71Tz0
Alessandro Borghesi retweeted
Type I IFN autoantibodies in three of seven Europeans with life-threatening Usutu virus infection rupress.org/jhi/article/3/1/…
Alessandro Borghesi retweeted
Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts @jhumimmunity @esiborghe @AurelieCobat
@ShenYingZhang1 @casanova_lab @grvsadrian @trespidifra
rupress.org/jhi/article/2/3/…
Alessandro Borghesi retweeted
Autoantibodies neutralizing type I IFNs in 40% of patients with WNV encephalitis in seven new cohorts rupress.org/jhi/article/2/3/…
We also speculate that some patients may initially present with a flu‑like illness (WNVF) and later progress to life‑threatening neuroinvasive disease (WNND) - a two‑step model closely resembling that observed in COVID‑19 pneumonia cell.com/med/fulltext/S2666-…
Antonio Piralla, Alberto Dolci, Danilo Cereda, Alessandro Aiuti, @JouanguyE, Paul Bastard, and to all the involved Institutions
In 2022, during an intense WNV summer outbreak, we discovered that a surprisingly high proportion of patients with WNV encephalitis (about half of our initial cohort) carry auto‑Abs neutralizing type I IFNs. Why did we choose to study WNV infection for auto‑Abs to type I IFNs?👇
With time, studies -and colleagues in hospitals and diagnostic centers- began to include in the WNVF “limbo” all patients with clinical signs who for various reasons did not undergo lumbar puncture or imaging to confirm/rule out neurological involvement... acpjournals.org/doi/10.7326/…
The initial definition of WNVF in the earliest seroepidemiological studies conducted in the USA in the early 2000s referred to individuals tested for WNV serology, self-reporting headache or a transient rise in body temperature in the preceding days thelancet.com/journals/lance…
In the 2023 paper, we observed that about 14% of cases (ranging from 0 in some centers to... 30%!! in others) with mild‑to‑moderate WNVF carried these auto‑Abs. Why did these individuals develop a milder form of the disease, despite the presence of the auto‑Abs? 👇
When, after the 2023 paper, we studied two new Italian cohorts from the 2023 summer outbreak, we were “happy” to replicate the ~40% auto‑Ab finding. This was already important. But we could not explain yet one finding on mild‑to‑moderate cases with WNV fever (WNVF).