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Galligan Lab (@galliganlab) profile picture

Galligan Lab

@galliganlab

We study how cell metabolism regulates chromatin structure and function.

 Tucson, AZ
galliganlab.com/
Joined May 2018
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Galligan Lab retweeted
Gregory Ducker (@gsducker) profile picture
Gregory Ducker@gsduckerOct 28
I'm very happy to share the final version of our paper, “MCT1-dependent mitochondrial lactate import sustains cardiac metabolism,” out in Nature! We show how lactate fuels heart mitochondria and helps protect the heart during stress. nature.com/articles/s41586-0… @UofUBiochem 1/10
MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

MCT1-dependent mitochondrial lactate import sustains cardiac metabolism

Nature - In mouse myocardium, glucose oxidation persists in the absence of the mitochondrial pyruvate carrier, with mitochondrial MCT1 importing lactate into mitochondria and LDHB oxidizing it to...

nature.com
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Non-enzymatic protein modifications at the interface of metabolism and immunity dlvr.​it/TVxXRH
Image from Cell Chemical Biology (@CellChemBiol)
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Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice - Hoffman - 2026 - Physiological Reports - Wiley Online Library physoc.onlinelibrary.wiley.c…
Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice

Glyoxalase 1 loss reduces fatty liver but impairs glucose handling in male mice

Loss of glyoxalase 1 has a minimal impact on protein glycation in a murine model for metabolic syndrome. These mice have reduced hepatic steatosis despite impaired glucose handling.

physoc.onlinelibrary.wiley.com
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Galligan Lab retweeted
Kivanc Birsoy (@KivancBirsoy) profile picture
Kivanc Birsoy@KivancBirsoySep 15
Why is glutathione, rather than cysteine, the major cellular thiol? Our new work by @ToshiNakamura51 suggests unlike other amino acids, excess cysteine is intrinsically toxic to mammalian cells via mitochondrial iron accumulation. @RockefellerUniv nature.com/articles/s42255-0…
Cysteine excess triggers a mitochondrial iron-dependent cell death

Cysteine excess triggers a mitochondrial iron-dependent cell death

Nature Metabolism - Using a genome-wide CRISPR screen, the authors demonstrate that excess cysteine drives mitochondrial iron accumulation and iron–sulfur cluster failure, triggering a...

nature.com
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Galligan Lab retweeted
Pankaj kapahi (@kapahi_pankaj) profile picture
Pankaj kapahi@kapahi_pankajAug 1
My lab is moving to Stanford, and we’re looking for an RA and a Postdoc to join us. The position will focus on ovarian and brain aging in flies. If you’re excited about genetics, aging, and discovery, we’d love to hear from you. Please email at [email protected]
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Galligan Lab retweeted
nature (@Nature) profile picture
nature
@NatureMay 29
Catalogue entries for more than 100 antibodies sold by the research services and supply company Thermo Fisher Scientific contain images that have apparently been manipulated, according to a pair of science sleuths. go.nature.com/4wZqGEE
Science sleuths uncover more than 100 suspicious images in Thermo Fisher antibody catalogue

Science sleuths uncover more than 100 suspicious images in Thermo Fisher antibody catalogue

Nature - Scientists have long worried about the reliability of commercial antibodies, and the latest findings have sparked fresh concerns.

nature.com
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5 more years of funding! If you are looking for a postdoc, reach out!
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Galligan Lab retweeted
Katherine Aird (@airdlab) profile picture
Katherine Aird@airdlabMay 27
It's time to rewrite reviews-aKG doesn't just regulate demethylation. Work from my lab and @mzspectrum demonstrates a new role for aKG in promoting histone acetylation and DNA repair through regulating carnitine synthesis. Congrats @ApoorvaUboveja! nature.com/articles/s41586-0…
αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

αKG-mediated carnitine synthesis drives DNA repair via histone acetylation

Nature - The metabolite αKG promotes carnitine synthesis and increases site-specific histone acetylation, thereby promoting homologous recombination-mediated DNA repair, which has potential...

nature.com
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The Kapahi Lab is looking for two creative, motivated postdocs to join our team. We use Drosophila to study neurodegeneration and aging -combine it with human genetics, and mammalian models to uncover fundamental mechanisms of aging. [email protected]
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A new paper used reactivity-based metabolomics to show that methylglyoxal and its main metabolite lactoylglutathione react rapidly with cysteines to generate L- and D-lactoylated thioesters suggesting an additional pathway to enable protein lactoylation nature.com/articles/s41589-0…
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A 2-for-1 resistance mechanism! Inspired by our colleague @Michael_A_Erb, @KaylaENutsch demonstrates that increased levels of acyl-CoAs not only promote resistance to active site HAT inhibitors but TEAD inhibitors as well. pubs.acs.org/doi/full/10.102…
Augmented Acyl-CoA Biosynthesis Promotes Resistance to TEAD Palmitoylation Site Inhibition

Augmented Acyl-CoA Biosynthesis Promotes Resistance to TEAD Palmitoylation Site Inhibition

Abstract. Activation of the YAP-TEAD transcriptional complex drives the growth of several cancer types and is a key resistance mechanism to targeted therap

pubs.acs.org
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nature.com/articles/d41586-0…
The antibodies don’t work! The race to rid labs of molecules that ruin experiments

The antibodies don’t work! The race to rid labs of molecules that ruin experiments

Nature - Poorly performing antibodies have plagued biomedical sciences for decades. Several fresh initiatives hope to change this.

nature.com
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Galligan Lab retweeted
CBC @ UA (@Biochem_Chem) profile picture
CBC @ UA@Biochem_Chem27 Sep 2024
The Department of Chemistry and Biochemistry at the U of A invites applications for a tenure-track Assistant Professor starting in Fall 2025. We seek candidates with a research and education program in analytical chemistry. This is a direct to job posting bit.ly/3zC3gfS
Image from CBC @ UA (@Biochem_Chem)
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Congratulations to the 2024 ChemTox Oral Presentation Award winners! @pivithuru_l @galliganlab @ChemistAndrea @trety001 #ACSFall2024
Image from Chemical Toxicology (@acschemtox)
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Galligan Lab retweeted
Dan Levy (@DanLevy_BGU) profile picture
Dan Levy@DanLevy_BGU19 Aug 2024
🔥The Levy lab at BGU is hiring🧬. We are looking for new team members (MSc, PhD students and post-docs) excited about chromatin biology, epigenetics and lysine methylation signaling in health and disease. Visit our lab website for more info: lifewp.bgu.ac.il/wp/ledan Please RT 📯
Image from Dan Levy (@DanLevy_BGU)
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Congratulations to @ChemResTox Young Investigator award winner Nate Snyder! @mzspectrum presented by @sshuck55
Image from Chemical Toxicology (@acschemtox)
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Galligan Lab retweeted
Katsu Funai (@KatsuFunai) profile picture
Katsu Funai@KatsuFunai8 Jul 2024
SLC7A5 is required for citrulline-dependent growth in arginine limited conditions @gsducker biorxiv.org/content/10.1101/…
SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

SLC7A5 is required for citrulline-dependent growth in arginine limited conditions

Tumor cells must optimize metabolite acquisition between synthesis and uptake from their surroundings. The tumor microenvironment is characterized by hypoxia, lactate accumulation, and depletion of...

biorxiv.org
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Excited to share our recent study on Biological and Genetic determinants of Red Blood Cell Glycolysis, now out @Cell_Metabolism - cell.com/cell-metabolism/ful…
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The Cortez lab (lab.vanderbilt.edu/cortez-la…) is looking for new postdocs or senior scientists. If you are interested in genome stability, replication, DNA repair, or DNA damage responses please send me an email.
Welcome

Welcome

10,000 Trillion cell divisions per lifetime; 6 billion base pairs per cell; Thousands of DNA lesions per cell per day; How does this work? Maintaining Genome Stability Billions of base pairs of DNA...

lab.vanderbilt.edu
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Online now - the Review "Functional implications of fumarate-induced cysteine #succination" from @iva_guberovic and Christian @FrezzaLab. #fumarate #oncometabolite #metabolicrewiring #fumaratehydratase #Fhdeficientcancers #biomarker authors.elsevier.com/sd/arti…
Image from Trends in Biochemical Sciences (@TrendsBiochem)
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