TokyoTech19B LST→23M LST→Science Tokyo 25D (D2) bioinformatics / deep learning / gLM / metagenomics
Joined November 2020
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口頭発表賞もいただきました
ありがとうございます！
W受賞です✌️
#CBI2025
紆余曲折あってツールの名前が変わりましたが、当時の成果が論文化されました
DeepRES改め、EnzyRExです
xitter.gq/h160ta/status/21178527…
Our paper is out now in Genome Biology!
We present EnzyREx, a deep learning framework for screening uncharacterized proteins against biochemical reactions, including those without known encoding genes (orphan reactions). (1/8)
link.springer.com/article/10…
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EC番号などの反応分類に依存せず、タンパク質と化学反応のクロスモーダル検索として酵素スクリーニングを行うAI手法としてEnzyRExを開発した研究がGenome Biology誌に掲載されました✌️
Our paper is out now in Genome Biology!
We present EnzyREx, a deep learning framework for screening uncharacterized proteins against biochemical reactions, including those without known encoding genes (orphan reactions). (1/8)
link.springer.com/article/10…
Our paper is out now in Genome Biology!
We present EnzyREx, a deep learning framework for screening uncharacterized proteins against biochemical reactions, including those without known encoding genes (orphan reactions). (1/8)
link.springer.com/article/10…
We then mapped candidates to gut microbial genomes and found putative gene clusters in 15 metabolic modules, including anthocyanin degradation. (8/8)
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Code: github.com/yamada-lab/EnzyRE…
Code/models/datasets: zenodo.org/records/22953569
Many thanks to everyone who supported this research!
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Keisuke Hirota retweeted
ゲノム言語モデルで生命科学を「観測」から「制御」へ
― AIによる予測と実験を循環させる次世代生命科学研究基盤の構築を始動 ― alis.rois.ac.jp/news/2026-00…
Keisuke Hirota retweeted
Kenso Soai – awarded the 2026 #NobelPrize in Chemistry – designed the first chemical reaction in which only one of the potential mirror images was formed. Other than life itself, no one had ever achieved this feat. The Soai reaction is one of the most spectacular chemical experiments ever conducted.
