Hot off the press: our latest work detailing a novel method for the light-inducible, cell-type specific labelling of newly synthesized proteins. This work is the fruit of a wonderful collaboration between the @KlannLab and @DirkTrauner labs! pubs.acs.org/doi/10.1021/acs…
In this paper, we demonstrate how photocaged versions of de novo protein tags, such as ANL, can be used to enable the light-dependent labelling of newly synthesized proteins in specific cell types, such as hippocampal excitatory neurons in mouse brain slices.
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A huge thank you to all the researchers and funding bodies who helped contribute to this work. Special mention most go to my wonderful co-first author, @tongil_ko! Without his expertise in synthetic chemistry and patience for us biologists, this work would not have been possible
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I’m very grateful to be #ALZFunded. The @alzassociation is an extremely supportive and generous funding partner. I would encourage anyone working in the #Alzheimers field to work with them!
Presenting at @SfNtweets 2023 tomorrow. Come learn about how we use FUNCAT labeling to visualize precise windows of #proteinsynthesis during #memory formation
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Check out @Mauricio_Neuro’s latest amazing work!
Here, he identifies GADD34 as a novel player in the intricate dance that is the regulation of mRNA translation in memory and characterizes its role
Really excited to share @Mauricio_Neuro's latest work, where he describes a novel mechanism for eIF2alpha dephosphorylation in response to plasticity-inducing stimulation, answering a long-standing question in the field of neuronal translation. Congrats! biorxiv.org/content/10.1101/…
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“We live with pride the love that others have had to live with fear”
Happy #Pride month – at West Village, Manhattan
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When you’re forced to use #Endnote for a grant application because it’s what the other authors prefer – at Manhattan, NY
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Very proud of our PhD student Sri who co-presented our work on impaired translation in tauopathies at #SfN22. Thank you to the rest of the @KlannLab , as well as The Leon Levy Foundation, @alzassociation and @RCFNeuro for their support – at San Diego, CA
Ok, that’s just awesome. Imagine a fine line glucose molecule for diabetics – at Manhattan, NY
Scientists have developed tattoos that change color in response to glucose, albumin, and pH levels. The new tech could let people with diabetes or kidney disease track and control their health without having to take frequent blood samples. doi.org/10.1002/anie.2019044…
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Yesterday I was thrilled and extremely grateful to find out that I had been awarded the @alzassociation
Research Fellowship. This funding will support my work within the @KlannLab exploring how impairments in protein synthesis contribute to various forms of dementia. #ENDALZ
Excited to present my work on tauopathy-induced impairments in protein synthesis at #Tau2022
