@hatmepp

Human African trypanosomiasis modelling and economic predictions for policy (HAT MEPP) aims to provide policy-ready results to support local HAT interventions

warwick.ac.uk/fac/cross_fac/zeeman_institute/new_research/combatting_disease/hat/hatmepp/
Joined November 2017
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A productive time was had last week with our collaborators from @ITMantwerp @LSTMvector and the DRC National Sleeping Sickness Control Programme at our HAT modelling workshop. Ce fut une expérience formidable et merci à ceux qui ont participé en personne et en ligne!
HAT MEPP Modelling workshop participants including ITM, LSTM and the DRC National Programme

ALT HAT MEPP Modelling workshop participants including ITM, LSTM and the DRC National Programme

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We are looking to appoint up to 3 x Research Associates or Postdoctoral Research Associates for an exciting infectious disease health economics opportunity in @hatmepp @uniofwarwick @WarwickSBIDER. Closing date Wednesday 5th June. warwick-careers.tal.net/vx/a…
https://warwick-careers.tal.net/vx/appcentre-ext/brand-4/spa-1/candidate/so/pm/1/pl/3/opp/1368-Research-Fellow-x3-109137-0524/en-GB

ALT https://warwick-careers.tal.net/vx/appcentre-ext/brand-4/spa-1/candidate/so/pm/1/pl/3/opp/1368-Research-Fellow-x3-109137-0524/en-GB

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🆕Latest research @drKatRock @Lloyd_Chapman @Andy2Dobson @dreradams1 @DeirdreHoll study overlooked challenges of asymptomatic infections in VL, gHAT & Chagas - vector borne parasitic diseases.​ 🔗bit.ly/3JWO52q 🧵⬇️
Image shows predicted impact of interventions on prevalence of 3 different neglected tropical diseases–gHAT, VL and Chagas disease–from the academic paper ‘The hidden hand of asymptomatic infection hinders control of neglected tropical diseases’. Pie charts show the contribution of different symptomatic or asymptomatic infection states to overall transmission and lines show the prevalence of each infection type. For gHAT it is estimated that many infections could be non-symptomatic (never progress to disease) and contribute considerably to transmission. Following active screening every year the proportion of non-symptomatics would be expected to increase despite a large overall reduction in infection prevalence. For VL most infections are thought to be non-symptomatic, but the main contribution to transmission comes from symptomatic people either with active VL or with the disease sequela post-kala-azar dermal leishmaniasis (PKDL). Under an intervention of reducing time to VL diagnosis

ALT Image shows predicted impact of interventions on prevalence of 3 different neglected tropical diseases–gHAT, VL and Chagas disease–from the academic paper ‘The hidden hand of asymptomatic infection hinders control of neglected tropical diseases’. Pie charts show the contribution of different symptomatic or asymptomatic infection states to overall transmission and lines show the prevalence of each infection type. For gHAT it is estimated that many infections could be non-symptomatic (never progress to disease) and contribute considerably to transmission. Following active screening every year the proportion of non-symptomatics would be expected to increase despite a large overall reduction in infection prevalence. For VL most infections are thought to be non-symptomatic, but the main contribution to transmission comes from symptomatic people either with active VL or with the disease sequela post-kala-azar dermal leishmaniasis (PKDL). Under an intervention of reducing time to VL diagnosis

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1/6 🎉Nous sommes ravis de partager notre pré-print sur le sujet préféré de Ron! Cliquez ci-dessous pour lire comment il a utilisé une approche statistique pour explorer le rôle des infections cachées de T.b. gambiense dans la dynamique de la transmission medrxiv.org/content/10.1101/…
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5/6 Le modèle montre une contribution limitée des infections cachées de T.b.gambiense à la transmission dynamique en RDC. Néanmoins, nous reconnaissons la possibilité du transmission asymptomatique, bien qu'elle ait un impact relativement mineur sur nos objectifs d'élimination.
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6/6 Elle pourrait être extrapolée à d'autres zones endémiques, mais ne pourrait pas possible dans pays d'Afrique de l'Ouest en raison de différences dans les interactions homme-parasite. L'ajout de données sur les infections cachées pourrait être un moyen d'adapter ces modèles.
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1/6 🎉 Excited to share our latest pre-printed paper on Ron’s favourite topic! Click below to delve into how Ron used a statistical approach to explore the role of hidden T.b. gambiense infections in transmission dynamics medrxiv.org/content/10.1101/… 👏👏👏 @RonCrump29
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5/6 Despite emerging evidence, the model shows limited contribution from hidden T.b. gambiense infections towards transmission dynamics in the DRC. Nevertheless, we acknowledge the potential for asymptomatic transmission but with relatively minor impact on elimination targets.
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6/6 This approach could be extrapolated to other endemic areas but it may not be possible in specific West African countries related to potential differences in human-parasite interactions. Adding region-specific data on hidden infections could be a way to adapt these models.
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1/6 🎉 HAT MEPP announce le pré-print de Marina Antillon impliquant une analyse coût-efficacité complète sur l'élimination du THAg à l'échelle nationale en RDC. Seulement 1/3 des zones de santé sont actuellement sur la bonne voie pour l'EdT d'ici 2030 👇👇medrxiv.org/content/10.1101/…
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5/6 L'introduction de nouvelles interventions d'atteindre l'EdT avec une probabilité > 90% nécessiterait un investissement plus de $47M et éviterait 561K AVCI mais près d'un cinquième de cette somme serait nécessaire la première année et des efforts opérationnels considérables.
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6/6 Cliquez ci-dessous pour découvrir les résultats de cette recherche à travers notre interface utilisateur graphique innovante.👇hatmepp.warwick.ac.uk/DRCCEA… #sleepingsickness #BeatNTDs @uniofwarwick @WarwickSBIDER @warwickmaths
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