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Jing Lyu (@jinglyu4) profile picture

Jing Lyu

@jinglyu4

Postdoc @fredrik_lanner lab | Ph.D. @simonelsasser lab | studying @stemcell @epigenomics @embryo

 Stockholm, Sweden
Joined July 2019
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Photo by Jing Lyu (@jinglyu4)Photo by Jing Lyu (@jinglyu4)Photo by Jing Lyu (@jinglyu4)Photo by Jing Lyu (@jinglyu4)Photo by Jing Lyu (@jinglyu4)Photo by Jing Lyu (@jinglyu4)
I am very happy that my paper is out on @NAR_Open now! Thanks a lot for the great support and guidance from my PhD supervisor Simon @simonelsasser, bioinformatic analysis support from Carmen and Rui, and experiment assistance of Philip! academic.oup.com/nar/advance…

Genome-wide mapping of G-quadruplex structures with CUT&Tag

Abstract. Single-stranded genomic DNA can fold into G-quadruplex (G4) structures or form DNA:RNA hybrids (R loops). Recent evidence suggests that such non-

academic.oup.com
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Early human development and stem cell-based human embryo models dlvr.it/TF0jqV
Early human development and stem cell-based human embryo models

Early human development and stem cell-based human embryo models

Stem cell-based models of the human embryo promise to transform the study of human embryogenesis. In this review, we discuss our current knowledge of the first 2 weeks of human embryo development and...

cell.com
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“Stem cells reverse woman’s diabetes — a world first. A 25-year-old woman with type 1 diabetes started producing her own insulin less than three months after receiving a transplant of reprogrammed stem cells.” nature.com/articles/d41586-0…
Image from Steve Stewart-Williams (@SteveStuWill)
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Exciting!
Jiarui Mi (@JiaruiMi) profile pictureJiarui Mi@JiaruiMi25 Sep 2024
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior rectus sheath in a type 1 diabetes patient: Cell cell.com/cell/fulltext/S0092…
Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior...

Transplantation of chemically induced pluripotent stem-cell-derived islets under abdominal anterior...

Chemically induced stem-cell-derived islets were transplanted beneath the abdominal anterior rectus sheath in one patient with type 1 diabetes, resulting in tolerable safety and promising restoration...

cell.com
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It took me SEVEN years to figure out that you can save a ggplot as a vectorized .svg file ggsave("file.svg"). The svg file can be opened on powerpoint and it will be completely vectorized, even text are still recognized as text boxes! No more recreating plots on illustrator!!!!!
Image from Leonardo Jo (@leonardojo)
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Happy to share our research highlight @NatureRevGenet featuring MARCS - the Modification Atlas of Regulation by Chromatin States: rdcu.be/dMYPD. Learn which PTMs a particular protein recognizes & discover the bona fide readers of specific PTMs at marcs.helmholtz-munich.de/
Image from Andrey Tvardovskiy (@ATvardovskiy)
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Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics dlvr.it/T9Cg9r
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New PhD position in the Lanner lab to establish stem cell-derived pancreatic islets for treatment of Diabetes. Studies performed within the prestigious National ATMP school. Join ⁦⁦@karolinskainst⁩ kidoktorand.varbi.com/en/wha…

Doctoral (PhD) student position to establish cell therapy for Diabetes, within National ATMP school

Do you want to contribute to top quality medical research? To be a doctoral student means to devote oneself to a research project under supervision of experienced researchers and following an individu

kidoktorand.varbi.com
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Happy to share the latest publication from the lab: XIST dampens X chromosome activity in a SPEN-dependent manner during early human development pubmed.ncbi.nlm.nih.gov/3883… Congrats to @CharbelFeghaly @JeffOui94 @manucazottes @GribnauLab, David lab @ParisEpigenetix
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Really excited about our review on 3D genome architecture and disease: nature.com/articles/s41576-0… in @NatureRevGenet with an amazing team @MundlosLab @Dariloops
Image from Malte Spielmann (@malte_spielmann)
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Long-range enhancer–promoter contacts in gene expression control go.nature.com/2WJp6p8 #Review by Stefan Schoenfelder & @Peter_Fraser1 @BabrahamInst
Image from Nature Reviews Genetics (@NatureRevGenet)
Image from Nature Reviews Genetics (@NatureRevGenet)
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Time-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics biorxiv.org/content/10.1101/…
Time-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics

Time-Resolved Interactome Profiling Deconvolutes Secretory Protein Quality Control Dynamics

Many cellular processes are governed by protein-protein interactions that require tight spatial and temporal regulation. Accordingly, it is necessary to understand the dynamics of these interactions...

biorxiv.org
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Blood-brain barrier assembloids from brain and blood vessel organoids using hESCs resemble the human BBB. bit.ly/4dMToPw #NBThighlight
Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived...

Modeling blood-brain barrier formation and cerebral cavernous malformations in human PSC-derived...

Guo and colleagues created human blood-brain barrier (hBBB) assembloids using stem cell-derived brain and blood vessel organoids. These models mimic key blood-brain barrier (BBB) characteristics and...

cell.com
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Glycosylation of proteins and lipids in mammals is essential for embryogenesis and the development of all tissues
Image from Nature Reviews Genetics (@NatureRevGenet)
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Online Now! Deciphering lineage specification during early embryogenesis in mouse gastruloids using multilayered proteomics dlvr.it/T6wYhx #stemcells
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What is the origin of our body? Our paper @CellCellPress shows that when a human embryo is one day old and comprises just two cells, only one cell will create most of the fetus in addition to placenta, while the other cell will create placenta. cell.com/cell/fulltext/S0092…
The first two blastomeres contribute unequally to the human embryo

The first two blastomeres contribute unequally to the human embryo

Labeling and live imaging of human embryos reveal that the majority of the future body originates, mostly, from one of the 2-cell stage blastomeres. Descendants of the first 2-cell stage blastomere...

cell.com
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Molecular pixelation describes an optics-free DNA barcoding strategy for spatial proteomics, enabling the identification of relative locations of proteins in single cells. nature.com/articles/s41592-0… #NBThighlight
Molecular pixelation: spatial proteomics of single cells by sequencing

Molecular pixelation: spatial proteomics of single cells by sequencing

Nature Methods - Molecular Pixelation is an optics-free method that uses DNA-tagged antibodies to enable identification of the relative location of proteins on single cells.

nature.com
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Exciting!
Google DeepMind (@GoogleDeepMind) profile pictureGoogle DeepMind
@GoogleDeepMind8 May 2024
Announcing AlphaFold 3: our state-of-the-art AI model for predicting the structure and interactions of all life’s molecules. 🧬 Here’s how we built it with @IsomorphicLabs and what it means for biology. 🧵 dpmd.ai/3URDiNo
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In our new preprint, we show that CRISPR activation of of just two endogenous regulatory elements is sufficient to self-organize embryonic stem cells into spatially-ordered embryonic patterns. biorxiv.org/content/10.1101/… #crispr
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Join my lab @karolinskainst for PhD studies in Early human embryo development, co-supervised by @simonelsasser and Andres Salumets! kidoktorand.varbi.com/en/wha…
Image from Fredrik Lanner (@fredrik_lanner)
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Thrilled to share that the central story of my PhD is now published in Development! We dig into how cell behavior and fate are intertwined, specifically in the context of how varying TBXT dosage influences the development of the nascent mesoderm. journals.biologists.com/dev/…
TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in...

TBXT dose sensitivity and the decoupling of nascent mesoderm specification from EMT progression in...

Highlighted Article: Using 2D human gastruloids, TBXT is shown to influence the timing of the epithelial-to-mesenchymal transition in a dose-dependent manner during early mesoderm development.

journals.biologists.com
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