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Johnson Mak

@johnsonmak

Virologist, @GlycoGriffith, @johnsonmak.bsky.social, molecular virology, cell biology, and biophysical tools. Co-Editor-in-Chief for Retrovirology

 Gold Coast, Queensland
Joined January 2011
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  • Following371
  • Followers280
8Media
Photo by Johnson Mak (@johnsonmak)Photo by Johnson Mak (@johnsonmak)Photo by Johnson Mak (@johnsonmak)Photo by Johnson Mak (@johnsonmak)Photo by Johnson Mak (@johnsonmak)Photo by Johnson Mak (@johnsonmak)
Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated oncogenic RNA with single-base precision | @Farehlab | Science Advances science.org/doi/10.1126/scia…

Principles of CRISPR-Cas13 mismatch intolerance enable selective silencing of point-mutated...

CRISPR-Cas13 precisely targets cancer-driving mutations with single-base accuracy, enabling tailored transcriptome editing.

science.org
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Glycan induced structural activation of HPV @NatureComms - rdcu.be/d1IVn
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Virus-modified paraspeckle-like condensates @WhitehouseLab rdcu.be/d1IPB
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rdcu.be/d1INL
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A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a broad array of enveloped viruses | @VirusesImmunity Science Immunology science.org/doi/10.1126/scii…
A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a...

A B cell screen against endogenous retroviruses identifies glycan-reactive IgM that recognizes a...

Profiling of ERV-reactive B-1 cells in mice reveals natural antibodies against terminal N-acetylglucosamine on multiple viral envelope proteins.

science.org
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🌏 Congratulations to Professor Patrick Reading on his appointment as Director of the WHO Collaborating Centre for Influenza! Prof Reading replaces Prof Kanta Subbarao, Honorary Fellow at @TheDohertyInst who led the Centre for eight years before taking up a prestigious professorial position in Canada earlier this year. @TheRMH @UniMelbMDHS go.unimelb.edu.au/wf98
Image from Doherty Institute (@TheDohertyInst)
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Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis | Science science.org/doi/10.1126/scie…
Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis

Retrotransposons are co-opted to activate hematopoietic stem cells and erythropoiesis

Hematopoietic stem cells (HSCs) and erythropoiesis are activated during pregnancy and after bleeding by the derepression of retrotransposons, including endogenous retroviruses and long interspersed...

science.org
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I am absolutely delighted on being elected a member of the US National Academy of Medicine. Grateful to many mentors, partners, collaborators, students and colleagues who have been part of my journey @SANTHEafrica @SciforAfrica @UCLInfectImm @HPP_Research @ragoninstitute
Africa Health Research Institute (@AHRI_News) profile pictureAfrica Health Research Institute@AHRI_News21 Oct 2024
We are delighted to share that AHRI director for basic & translational science Prof @Thumbi_Ndungu has been elected as a member of @theNAMedicine Election is one of the highest honours in the fields of health & medicine. 🎉 Congrats, Thumbi! More ➡️ ahri.org/prof-thumbi-ndungu-…
Image from Africa Health Research Institute (@AHRI_News)
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Hot off the press 🔥 Host cell glycosylation selects for infection with CCR5- versus CXCR4-tropic HIV-1 Spearheaded by @HannahItell nature.com/articles/s41564-0…
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LINE1 modulate human T cell function by regulating protein synthesis during the life span | Science Advances science.org/doi/10.1126/scia…
LINE1 modulate human T cell function by regulating protein synthesis during the life span

LINE1 modulate human T cell function by regulating protein synthesis during the life span

The levels of LINE1 expression regulate the rate of protein synthesis throughout the human life span.

science.org
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Wow! Spectacular news for the HIV prevention armamentarium: Lenacapavir showed 100% efficiency...they stopped the blinded phase of the trial to offer it to all participants...aaand it's twice yearly regimen! long way since the muliple horse pills per day! reuters.com/business/healthc…
Gilead's long-acting HIV drug superior to daily pill Truvada in study

Gilead's long-acting HIV drug superior to daily pill Truvada in study

Gilead Sciences said on Thursday a late-stage study showed its long-acting injectable drug was more effective in preventing HIV infection in women compared to its existing daily pill Truvada, sending...

reuters.com
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What has 126 figure panels and a completely new antiviral pathway? The @GammonLab's latest paper in @NatureMicrobiol, featuring student Emily Rex's tour de force discovery of the FEAR pathway. Huge congrats to the team! nature.com/articles/s41564-0…
Image from Julie Pfeiffer (@jkpfeiff)
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Endogenous feline leukemia virus long terminal repeat integration site diversity is highly variable in related and unrelated domestic cats dlvr.it/T2m6hm
Image from Retrovirology (@Retrovirology)
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Researchers solve an 80-year mystery confirming categorically that mosquitoes transmit Mycobacterium ulcerans, the bacteria that causes #BuruliUlcer, from the environment to humans.🦟 doherty.edu.au/news-events/n… Published in @NatureMicrobiol, led by @tstinear @UniMelbMDHS @TheRMH
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Retrovirology is proud to have a new article collection, entitled "HIV infection of uncommon host cells", guest edited by J Victor Garcia-Martinez of University of North Carolina Read the published articles at: biomedcentral.com/collection…
Image from Retrovirology (@Retrovirology)
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BREAKING🔔 A new study from G2P-Japan🇯🇵 is out! The preprint will be out so soon, but we first show our results on the efficacy of XBB.1.5 monovalent vaccine - comparison between infection-naïve and XBB-infected individuals. Please retweet/repost🔥 1/
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POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape from innate immune sensing | Science Advances science.org/doi/10.1126/scia…
POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape...

POLE3 is a repressor of unintegrated HIV-1 DNA required for efficient virus integration and escape...

The repressive chromatin structure of unintegrated HIV-1 DNA ensures efficient integration and escape from innate immunity.

science.org
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Hydrogel implant rehabilitates muscles through electrical stimulation nature.com/articles/d41586-0…
Hydrogel implant rehabilitates muscles through electrical stimulation

Hydrogel implant rehabilitates muscles through electrical stimulation

Nature - A conductive prosthesis that reconnects injured muscle to nerve.

nature.com
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Selective control of transposable element expression during T cell exhaustion and anti–PD-1 treatment | Science Immunology science.org/doi/10.1126/scii…
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Delighted to share our article @Nature identifying TMPRSS2 as a functional receptor for seasonal #coronavirus HKU1. Congrats to @SaundersNell1 @JBuchrieser and wonderful collaborators from @institutpasteur and @amsterdamumc nature.com/articles/s41586-0…
Image from Olivier Schwartz Lab (@Virus_Immunity)
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