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Lifespan Magazine & The Lifespan Show provide evidence-based information so you can live your longest, healthiest life while supporting medical research 🧬💪

lifespan.com
Joined March 2026
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People are living longer than ever. But could the average lifespan really jump by another 10 years? Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…
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Pooling 20.9 million observations across 199 studies: high fitness cuts mortality risk 53% versus low
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Read: doi.org/10.1136/bjsports-202…

Cardiorespiratory fitness is a strong and consistent predictor of morbidity and mortality among...

Objective To examine and summarise evidence from meta-analyses of cohort studies that evaluated the predictive associations between baseline cardiorespiratory fitness (CRF) and health outcomes among...

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Just out: Living longer, but Not Better? lifespan.com/blogs/magazine/…

Living Longer, but Not Better?

The word healthspan has become one of the most popular terms in longevity science. Longevity clinics promise to extend it. Supplement companies claim to protect it. Researchers who study aging,...

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Why are we living longer but not better? Lifespan.com/blogs/magazine/…
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What role can AI play in healthy aging? Learn more from Microsoft’s Chief Medical Officer in an interview with Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…

From Bedside to Cloud: Dr. David Rhew on Using AI to Help Us Age Well

Dr. David Rhew is a physician, researcher, and technologist who has spent his career trying to make healthcare both smarter and more humane. He is currently the Global Chief Medical Officer at...

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A new study found that NAD+ levels in whole blood stay surprisingly stable throughout adulthood. So why are scientists still studying NAD+? Learn more from Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…

Blood NAD+ Levels Tell Us Less Than Many People Think

One of the easiest mistakes in science is to confuse a single measurement with the whole reality. We do it all the time. An investor watches a stock price and forgets that the ticker is not the...

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The scientific truth about peptides: Which ones work? Which ones are hype? Which ones to avoid! youtu.be/3CnKnIXKDoE?is=Bf6a…

Younger Skin with Peptides? | Lifespan with Dr. David Sinclair - S2,...

At Lifespan, our mission is to help you and your loved ones live yo...

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Mice engineered to overexpress klotho lived 20–30% longer with no signs of illness doi.org/10.1126/science.1112…

Suppression of Aging in Mice by the Hormone Klotho

A defect in Klotho gene expression in mice accelerates the degeneration of multiple age-sensitive traits. Here, we show that overexpression of Klotho in mice extends life span. Klotho protein...

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A randomized trial gave middle-aged adults Urolithin A for 4 months. Muscle strength improved ~12%
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Read here: doi.org/10.1016/j.xcrm.2022.…
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Exercise is one of the most reliable ways to protect health as you age. Rapamycin is a closely watched longevity drug. What happens when you combine them? Read more from Lifespan Magazine lifespan.com/blogs/magazine/…

Does Rapamycin Block the Benefits of Exercise?

Many, many miles west of South America lies a small, triangle-shaped island housing hundreds of ancient, giant stone statues. The native name for this island is Rapa Nui and, in 1722, explorers from...

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You’ve heard the talk: Longevity science is all hype. David Sinclair has heard it too. In his new editorial, he takes the criticism head-on and asks a bigger question: what could we lose by dismissing longevity research? Read Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…
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Repair genes don't turn on by request, they turn on by demand
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Senescent cells are like older people - they stop working and start shouting at their neighbors
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New menopause study shows abrupt shifts up to a year before the final menstrual period. Hormone therapy appears to erase much of "the cliff”. What organs were protected and can we use this information to prevent diseases? lifespan.com/blogs/magazine/…
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Some organs can age faster than others, raising a new question: could the oldest part of you help predict what happens next? Read more on Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…
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A 12-week NMN trial in 11 volunteers raised plasma NMN and insulin Read here: doi.org/10.1016/j.clnesp.202…
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Lifespan retweeted
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A longer life begins with a simple question: What can I do today that my future self will thank me for?
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Prof. Sinclair was on a panel at a NYC longevity event hosted by @McKinsey. Low dose GLP-1s was the hot topic. Read more lifespan.com/blogs/magazine/…

Semaglutide and the Longevity Question

There has been plenty of chatter about whether GLP-1 drugs might be longevity drugs in disguise. A new study in Nature adds the most direct preclinical evidence yet: semaglutide extended lifespan in...

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