Professor researching why we age & how to reverse it. Author & host of Lifespan. Mission: Extend healthy life for all. Views are entirely his own. @joinlifespan
Harvard
Joined March 2012
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Breaking
lifespan.com/blogs/magazine/…
So true - the Information theory of aging in 2008:
NAD+ ➡️ sirtuins ➡️ histone modification ➡️ epigenetic stability ➡️ cellular identity ➡️ slower aging
cell.com/cell/fulltext/S0092…
NAD boosting and epigenetic restoration are two levers aimed at the same aging biology. David Sinclair (Harvard Medical School) at #ARDD2026. Photos: agingpharma.org/photos2026
It’s confusing. Some studies examine sildenafil (Viagra), others tadalafil (Cialis). So many new studies are indicating surprisingly positive effects on various organs & even immune cells fighting cancer. How about a new Lifespan episode called “What’s not to love?”
There is no convincing evidence that low dose Cialis associated with altered lens proteins or causes cataracts. There are potential side-effects to discuss with a physician, like a potentially slightly higher occurrence of a “stroke in the eye” (NAION), as with GLP-1RAs
David Sinclair retweeted
People are living longer than ever. But could the average lifespan really jump by another 10 years? Lifespan Magazine 📚️ lifespan.com/blogs/magazine/…
Today it was great meeting with the team to chart the future
The story of this technology is amazing. Happy to be able to share it, and big kudos to @davidasinclair lab in originating it!
NEW PAPER: In rats, the NAD booster NMN effectively alleviates polycystic ovary disease, a common cause of infertility, by increasing SIRT2 activity, suggesting NMN as a possible therapeutic
Highlights from authors:
1. NMN effectively ameliorates metabolic and endocrine disorders in PCOS
2. NMN activates granulosa cell glycolysis via SIRT2-mediated LDHA deacetylation
3. LDHA then converts pyruvate to lactate
3. K119 is a critical functional acetylation site of LDHA.
4. Targeting the SIRT2/LDHA-K119 axis improves follicular development in PCOS
Again, what’s not to love?
Tadalafil, a drug used for erectile dysfunction, was tested in head-and-neck cancer patients! Researchers reported reduced suppressive immune-cell populations and stronger tumor-specific immunity. An unexpected direction for cancer immunotherapy!
pubmed.ncbi.nlm.nih.gov/2532…
Badly needed
SIRT6 Activation Improves Intervertebral Disc Health in the Aging Spine
onlinelibrary.wiley.com/doi/…
Just out: Living longer, but Not Better?
lifespan.com/blogs/magazine/…
