@lab_grey

The Grey lab focuses on studies of host-virus interactions using systematic approaches 🦠🧪🧫🧬💊 #Virology

 Edinburgh, Scotland
ed.ac.uk/roslin/systems-virology-group
Joined January 2020
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  • Following115
  • Followers219
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The Grey Lab uses cutting-edge tools to examine the interactions between the host and pathogens such as cytomegalovirus, influenza virus and African Trypanosomiasis. ed.ac.uk/roslin/systems-viro…
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A recent review written by our lab. Check it out -
Christine Mordstein@CMordstein22 Sep 2021
Does the Zinc Finger Antiviral Protein (ZAP) Shape the Evolution of Herpesvirus Genomes? @lab_grey mdpi.com/1274990
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"Hematopoietic cell-mediated dissemination of murine cytomegalovirus is regulated by NK cells and immune evasion" New work from @lab_grey @roslininstitute, Shunchuan Zhang Christopher Snyder @KimmelCancerCtr and colleagues. buff.ly/3oAYiog
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Now recruiting!! @wellcometrust 4-year PhD programme in Hosts, Pathogens and Global Health @EdinburghUni Projects focusing on the immunology, epidemiology, evolutionary biology and ecology of infection. Apply now! edin.ac/2oDtl9z @wt_hpgh @KeithRMatthews @SBSatEd
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Registration now open!! We are delighted to invite you to the virtual edition of the 9th Annual Edinburgh Infectious Diseases Symposium! eidsymposium2020.eventbrite.… @SBSatEd @roslininstitute @ScienceUoE @EdinUniUsher @EdinUni_MeetCIR @UoE_IM @KeithRMatthews @jrossfitz @MRC_IGMM
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Check out Abraham’s video for entering the 2020 Sir Howard Dalton Young Microbiologist of the Year competition. You can also check out other finalists’ videos on microbiologysociety.org/news… Good luck to Abraham! 👍🏻 #YMOY2020
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Big shout out to our ex-PhD student Abraham who has been selected as a finalist of Young Microbiologist of the Year competition!! He will present his talk on Wed 25th November. #YMOY2020 microbiologysociety.org/news…
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We have found some robust new discoveries about Covid-19 in GenOMICC, which have potential therapeutic relevance. Readers outside of the genomics community will want to wait for peer review before acting on these findings. Preprint here for specialists: medrxiv.org/content/10.1101/…

Genetic mechanisms of critical illness in Covid-19

The subset of patients who develop critical illness in Covid-19 have extensive inflammation affecting the lungs[1][1] and are strikingly different from other patients: immunosuppressive therapy...

medrxiv.org
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Despite a slight Covid delay, our paper is now live on PLoS Path. Excellent work by Yao-Tang Lin and Stephen Chiweshe and collaboration with @Simmonds_Lab and @WilsonLabCVR. “Human cytomegalovirus avoids detection by ZAP and TRIM25 regulates ZAP splicing.” journals.plos.org/plospathog…

Human cytomegalovirus evades ZAP detection by suppressing CpG dinucleotides in the major immediate...

Author summary The evolutionary success of viruses is dependent on their ability to circumvent defence mechanisms of the hosts they infect. These defence mechanisms rely on the ability of the host to...

journals.plos.org
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Check out our most recent review on Systems Virology and Human Cytomegalovirus: Using High Throughput Approaches to Identify Novel Host-Virus Interactions During Lytic Infection. #HCMV #Review #HTS frontiersin.org/article/10.3…
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Are you a non-virologist PhD/postdoc interested in doing a virology PhD? If so, please chat to us about this opportunity: hfsp.org/funding/hfsp-fundin…. Our lab works on influenza A virus, rotaviruses and now SARS-CoV-2!
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A latest update on the relationship between PML bodies and HCMV IE1 protein. The study provides initial evidence for the idea that disruption of PML bodies upon viral infection is linked to activation rather than inhibition of innate immunity! journals.plos.org/plospathog…

Revisiting promyelocytic leukemia protein targeting by human cytomegalovirus immediate-early...

Author summary Promyelocytic leukemia (PML) bodies are liquid droplet-like structures organized by the eponymous PML proteins in the nuclei of our cells. PML bodies have been implicated in the...

journals.plos.org
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Our paper describing CpG composition of SARS-CoV-2 in context with other CoVs now up on BioRxiv. Take aways: Huge diversity in CpG composition across CoVs E ORF and ORF10 have lots of CpGs, host derived No evidence for SARS-CoV-2 being adapted in canines biorxiv.org/cgi/content/shor…
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The Grey Lab retweeted
Krogan Lab@KroganLab23 Mar 2020
Our paper is out on @biorxivpreprint describing our SARS CoV2-human protein-protein interaction map and drug predictions from the data. It was a honor to work with so many fantastic scientists around the world. -Nevan biorxiv.org/content/10.1101/…

A SARS-CoV-2-Human Protein-Protein Interaction Map Reveals Drug Targets and Potential Drug-Repurp...

An outbreak of the novel coronavirus SARS-CoV-2, the causative agent of COVID-19 respiratory disease, has infected over 290,000 people since the end of 2019, killed over 12,000, and caused worldwide...

biorxiv.org
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MicroSoc 2020 still to go ahead! I hope to see you all in Edinburgh! Please RT Response to concerns about the novel coronavirus (SARS-CoV-2) | Microbiology Society microbiologysociety.org/news…
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Save the date!!! 25th Glasgow Virology Workshop is happening on the 4th of Sept, 2020! We have some awesome scientists that we’ll reveal in time. A day that showcases groundbreaking science, promotes young scientists and ends with a ceilidh. I love it!! #GVW2020 @cvrinfo
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courtesy of @lab_grey , the scientific definition of irony
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Steroids are still in wide use for nCoV infection (as with SARS and MERS). But WHO recommend against, and the balance of evidence suggests harm. @clarkdrussell @jemillarni and I summarise the evidence in this paper, published a few minutes ago: thelancet.com/lancet/article…
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Please share far and wide: a free, open access, flexible research protocol for clinicians who want to run their own studies of nCoV2019. If we harmonise sampling globally we can combine independent work. The @ISARIC1 clinical characterisation protocol: isaric.tghn.org/CCP
Image showing tiers of recruitment intensity in a flexible observational research design

ALT Image showing tiers of recruitment intensity in a flexible observational research design

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#Coronaviruses are a family of viruses that can infect a range of hosts. They are known to cause diseases including the common cold, SARS and MERS in humans. You can find relevant research on this topic in this journal collection which is freely available: microb.io/2O2AsC2
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Professor Jurgen Haas was on the BBC radio Good Morning Scotland programme this morning talking about the coronavirus outbreak in China (skip to 2:13:00): bbc.co.uk/programmes/m000dgx… A TV interview will be boardcast tonight at 6:30pm on Reporting Scotland.
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