People with fatty liver took 144 mg cranberry capsules or placebo for 6 months. Fasting insulin was almost halved. HOMA-IR, a measure of insulin resistance, halved from 2.8 to 1.4 in the cranberry group. "The results of the present study showed that cranberry supplementation had a positive effect on some lipid profiles, insulin resistance, and hepatic steatosis in patients with NAFLD." Fruits are the best carbs for insulin resistance because of their polyphenol, mineral, vitamin, and fiber content. Cranberry powder extract improved gut microbiota, reducing endotoxin, in rodents fed a high-fat, high-sugar diet. xitter.cf/lowmegatron/status/211…

Camu-Camu reduces liver fat: 1.5g of Camu-Camu powder per day reduced liver fat by 7%, while it increased by 8% over the same 12-week period in the placebo group. The 15% difference in liver fat was assessed by MRI. ALT dropped 11% in the Camu-Camu group and increased 13% in the placebo group. The trial included 30 overweight people with hypertriglyceridemia. The benefits are partly due to changes in gut flora. “These findings support that polyphenol-rich prebiotic may reduce liver fat… reducing the risk of developing NAFLD.” xitter.cf/lowmegatron/status/211…

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TSH is directly cardiotoxic via affecting the mitochondria of the heart, PGC-1α proven protective once again:

Why do these characters keep pretending that fruit juice is just sugar and water? 1L of orange juice contains significant amounts of thiamine, folate, magnesium, and potassium, as well as 5x the RDA for vitamin C. Fruit juices also contain many beneficial bioactive compounds such as narirutin, naringenin, hesperidin, nobelitin, tangeretin, and a whole host of anthocyanins. We have studies assessing the effect of orange juice against sugar+water in humans. “The combination of glucose or water and the high-fat, high-carb meal induced oxidative and inflammatory stress and an increase in TLR expression and plasma endotoxin concentrations. In contrast, orange juice intake with the high-fat, high-carb meal prevented meal-induced oxidative and inflammatory stress, including the increase in endotoxin and TLR expression. These observations may help explain the mechanisms underlying postprandial oxidative stress and inflammation, pathogenesis of insulin resistance, and atherosclerosis.” xitter.cf/KenDBerryMD/status/211…

Orange juice is not a health food. It's sugar water with a good publicist. One 8 oz glass = about 20 grams of sugar. That's 5 sugar cubes. And about half of that is fructose, the same sugar we're blaming for the fatty liver epidemic in kids. No fiber. No protein. No fat. Just sugar water with a pinch of vitamin C... Eat an orange if you must. Better yet, eat some eggs. Carbs are optional & not needed.

Thiamine supplementation diminished fatigue, maximized feelings of well-being, and restored appetite. 10 mg thiamin HCL daily: —Appetite improved from 6.1 to 9.5 —Fatigue decreased from 4.9 to 1.2 —Well-being increased from 4.8 to 8.8 On a scale from: 0—I never have the condition or problem to 10—I have the condition or problem all the time The research was done in healthy older women at risk for marginal thiamin deficiency. “Fatigue lessened significantly with thiamin supplementation. There was a trend in the supplemented group to less daytime sleep, watching television and listening passively to the radio, and spending more time on active isolated activities such as housecleaning and gardening.” “General well-being improved significantly with thiamin supplementation. Eighty-eight percent of subjects supplemented with thiamin expressed feeling "brighter" and "cheerier" than before supplementation. It has been estimated that approximately 20% of the elderly suffer from varying degrees of depression, a disease with multiple causes (43); it appears that compromised thiamin status may be one of the factors.” “Prior to treatment, 85% of subjects expressed no desire for meals, but ate because of habit. Improved thiamin status significantly increased appetite. Sixty-three percent of thiamin-supplemented subjects reported an increased appetite and enjoyment of meals. The increased appetite with supplementation was reflected in significantly higher energy intakes and weight gain. Previous research has found that major problems among the elderly include anorexia and weight loss (43,44). Although both of these conditions are considered multicausal, the majority of cases are of unknown etiology (45,46). Assessment of thiamin status for both conditions is indicated by the present results.” Ref: Influence of Thiamin Supplementation on the Health and General Well-being of an Elderly Irish Population With Marginal Thiamin Deficiency

Orange juice > Lowers insulin > Lowers blood sugar > Lowers inflammation > Improves insulin sensitivity Drinking more than 500ml/day was associated with a greater reduction in insulin resistance and blood sugar. Meta-analysis of ten RCTs. “The current meta-analysis on available RCTs suggested that orange juice consumption might have beneficial effects on glucose, insulin, HOMA-IR, total cholesterol, LDL-C, and CRP levels compared to control groups. However, the effects of orange juice on body composition factors and other cardiovascular risk factors were not significant compared to the control group. These lowering effects of glucose, HOMA-IR, total cholesterol, and LDL-C were robust in subgroups with orange juice consumption ≥500 ml/day.” PMID: 33350317 Orange juice lowers blood pressure. The effect is partly due to its hesperedin content, as adding more hesperedin to orange juice further reduces blood pressure. “Hesperidin in orange juice reduces systolic blood pressure and pulse pressure after sustained consumption, and after a single dose, the chronic consumption of hesperidin-enriched OJ enhances its postprandial effect. Decreases in systemic and transcriptomic biomarkers were concomitant with BP and PP changes. Hesperidin-enriched OJ could be a useful co-adjuvant tool for BP and PP management in pre- and stage-1 hypertensive individuals.” 500 mL/day. The hesperidin-enriched OJ was equivalent to 1L/day. PMID: 32661681 Orange juice helps lower endotoxin and the associated metabolic damage. ↓ Insulin ↓ Blood sugar ↓ Inflammation ↓ Blood endotoxin ↓ Endotoxin immune response Participants were given meals of egg-muffin and sausage-muffin sandwiches and two hash-brown potatoes that contained 81 g of carbohydrates, 51 g of fat, and 32 g of protein. They had one of 3 drinks with the meal: water, glucose + water, or orange juice with the same amount of natural sugar. All parameters were much improved with orange juice compared to water or sugar water. “The combination of glucose or water and the high-fat, high-carb meal induced oxidative and inflammatory stress and an increase in TLR (endotoxin receptor) expression and plasma endotoxin concentrations. In contrast, orange juice intake with the high-fat, high-carb meal prevented meal-induced oxidative and inflammatory stress, including the increase in endotoxin and TLR expression... This is also relevant to the pathogenesis of atherosclerosis and insulin resistance because TLR4 and TLR2 were incriminated in the pathogenesis of atherosclerosis and insulin resistance. The expression of TLR4 is observed in atherosclerotic plaques, whereas TLR4 deletion protects mice from atherosclerosis and insulin resistance induced by a high-fat diet.” PMID: 20200256 xitter.cf/davidasinclair/status/…