Volkan K. Koseoglu (@microbencell) header
Volkan K. Koseoglu (@microbencell) profile picture

Volkan K. Koseoglu

@microbencell

Assistant Professor @wakeforestmed | Postdoc @AgaisseLab | PhD @UWyonews | MSc & BSc @itu1773 | Interested in bacterial pathogenesis

 Winston-Salem, NC
Joined November 2016
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Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)Photo by Volkan K. Koseoglu (@microbencell)
Excited to share the first peer-reviewed paper from my lab! We found that a colonic bile acid drives Shigella aggregation through its T3SS, repurposing an essential invasion apparatus to build multicellular communities. #Shigella #T3SS #BileAcids journals.asm.org/doi/10.1128…
Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggrega...

Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggrega...

Shigella spp. are the causative agents of bacillary dysentery, or shigellosis, a highly contagious diarrheal disease characterized by abdominal cramps, fever, severe diarrhea, and stools containing...

journals.asm.org
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First preprint from the lab is out! 🎉 Huge credit to our talented lab tech, Jonah Lanier, who led this project.
bioRxiv Microbiology (@biorxiv_micrbio) profile picturebioRxiv Microbiology@biorxiv_micrbio25 Nov 2025
Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates biorxiv.org/content/10.1101/… #biorxiv_micrbio
Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates

Lithocholic acid induces T3SS-dependent formation of invasion-competent Shigella flexneri aggregates

Shigella flexneri causes shigellosis, the second leading cause of diarrheal deaths worldwide. The pathogen invades colonic epithelial cells using a type III secretion system (T3SS) that delivers...

biorxiv.org
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Role of listeriolysin O and phospholipases C in L. monocytogenes intercellular protrusion dynamics, resolution, and autophagy avoidance | mBio journals.asm.org/doi/full/10…
Role of listeriolysin O and phospholipases C in L. monocytogenes intercellular protrusion dynamics,...

Role of listeriolysin O and phospholipases C in L. monocytogenes intercellular protrusion dynamics,...

Intracellular bacterial pathogens, including L. monocytogenes, spread from cell to cell to effectively disseminate within host tissues and cause systemic infections. We developed a fluorescence...

journals.asm.org
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Making contact away from home: a bacterial secreted effector mediates inter-organelle communication | EMBO reports embopress.org/doi/full/10.10…
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The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic bacteria against interferon-induced ubiquitylation biorxiv.org/content/10.1101/…
The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic...

The Shigella flexneri effector IpaH1.4 facilitates RNF213 degradation and protects cytosolic...

A central signal that marshals host defense against many infections is the lymphocyte-derived cytokine interferon-gamma (IFNγ). The IFNγ receptor is expressed on most human cells and its activation...

biorxiv.org
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Fantastic defense! Congratulations Dr. Tufan @trn_tfn
Image from Volkan K. Koseoglu (@microbencell)
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Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar Typhimurium via the de novo purine pathway | Infection and Immunity journals.asm.org/doi/abs/10.…
Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar...

Lactate promotes the biofilm-to-invasive-planktonic transition in Salmonella enterica serovar...

When colonizing the gut, Salmonella enterica serovar Typhimurium (S. Typhimurium) adopts a dynamic lifestyle that alternates between a virulent planktonic state and a multicellular biofilm state. The...

journals.asm.org
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Intact and mutated Shigella diguanylate cyclases increase c-di-GMP sciencedirect.com/science/ar…
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A very cool review on one of my favorite topics by @BCRussoLab Pushing boundaries: mechanisms enabling bacterial pathogens to spread between cells | Infection and Immunity journals.asm.org/doi/full/10…
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PurA is the main target of aurodox, a type III secretion system inhibitor | PNAS pnas.org/doi/abs/10.1073/pna…
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Intact and Degenerate Diguanylate Cyclases regulate Shigella Cyclic di-GMP biorxiv.org/content/10.1101/…
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Removal of Pseudomonas type IV pili by a small RNA virus | Science science.org/doi/full/10.1126…
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Full article: Gastrointestinal signals in supplemented media reveal a role in adherence for the Shigella flexneri sap autotransporter gene tandfonline.com/doi/full/10.…
Gastrointestinal signals in supplemented media reveal a role in adherence for the Shigella flexneri...

Gastrointestinal signals in supplemented media reveal a role in adherence for the Shigella flexneri...

Shigella flexneri causes severe diarrheal disease worldwide. While many aspects of pathogenesis have been elucidated, significant knowledge gaps remain regarding the role of putative chromosomally-...

tandfonline.com
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Lymph node stromal cells vary in susceptibility to infection but can support the intracellular growth of Listeria monocytogenes academic.oup.com/jleukbio/ar…
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Legionella pneumophila usurps host cell lipids for vacuole expansion and bacterial growth journals.plos.org/plospathog…
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Shigella virulence protein VirG is a broadly protective antigen and vaccine candidate nature.com/articles/s41541-0…
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Cell death induction facilitates egress of Coxiella burnetii from infected host cells at late stages of infection Molecular Microbiology | Microbiology Journal | Wiley Online Library onlinelibrary.wiley.com/doi/…
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(p)ppGpp is required for virulence of Shigella flexneri | Infection and Immunity journals.asm.org/doi/10.1128…
(p)ppGpp is required for virulence of Shigella flexneri | Infection and Immunity

(p)ppGpp is required for virulence of Shigella flexneri | Infection and Immunity

Shigella spp. are an enteric, pathogenic bacterial genus that is responsible for diarrhea-associated morbidity and mortality, primarily in people living in low- and middle-income countries (1)....

journals.asm.org
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Enteropathogenic E. coli infection co-elicits lysosomal exocytosis and lytic host cell death | mBio journals.asm.org/doi/full/10…
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RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading: iScience cell.com/iscience/fulltext/S…
RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading

RACK1 promotes Shigella flexneri actin-mediated invasion, motility, and cell-to-cell spreading

Cellular physiology; Bacteriology; Functional aspects of cell biology

cell.com
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