O2matic

🩸 REDOX-AHF (NCT05613218) — Does the oxygen target we set in AHF actually matter? #HFA2026 We give O₂ to almost every AHF patient. Guidelines say start if SpO₂ <90%. But in practice, most patients are targeted to ≥95% or higher — without RCT evidence. 📋 Design: Phase II/III | RCT | Triple-blind | Parallel-group Sponsor: Copenhagen University Hospital, Hvidovre, Denmark 👥 Population: Adults admitted to ED with AHF + pulmonary congestion + hypoxaemia n = 122 🔀 Arms (1:1): ▪ Liberal: SpO₂ target 96% ▪ Restrictive: SpO₂ target 90% Key innovation: Blinding achieved via O2MATIC — a closed-loop automated oxygen delivery robot → Titrates O₂ every second to the prespecified target → Eliminates manual titration bias → Maintains SpO₂ within target ~87% of the time vs ~61% with manual care Why it matters: Hyperoxia → ↑ coronary vascular resistance, ↑ SVR, ↓ cardiac output Normoxic AHF patients given O₂ → no survival benefit, longer LOS But no powered RCT has ever tested this in AHF. Until now. #HeartFailure #AcuteHeartFailure #Oxygen #HFA2026 #Cardiology