@osturmscience

Interested in Stress, Behaviour and Electrochemistry.

 Zurich, Switzerland
Joined June 2018
  • Tweets105
  • Following244
  • Followers243
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How much analgesia is needed to manage pain levels in mice after brain surgeries? A single dose of meloxicam seems to be enough. Even the addition of opioids cannot provide a clear benefit (in line with recent work from others, see refs in our preprint): biorxiv.org/content/10.1101/…

GrimACE: Automated, multimodal cage-side assessment of pain and well-being in mice

Pain and welfare monitoring is essential for ethical animal testing, but current cage-side assessments are qualitative and subjective. Here we present the GrimACE, the first fully standardised and...

biorxiv.org
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Just arrived in Orlando, anyone else at #2025SOT?
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Oliver Sturman retweeted
Johannes Bohacek@BohacekLab6 Mar 2025
We just released the largest amount of stress profiling data from our (any?) lab so far! How does the molecular stress response adapt as an acute stressor becomes chronic? Multiomic profiling in the 🐭 hippocampus, led by @RebeccaWaag and co-last author Pierre-Luc Germain! 💪
bioRxiv Neuroscience@biorxiv_neursci5 Mar 2025
Distinct molecular mechanisms of stress habituation in the mouse hippocampus biorxiv.org/content/10.1101/… #biorxiv_neursci

Distinct molecular mechanisms of stress habituation in the mouse hippocampus

Chronic stress is a risk factor for neuropsychiatric disorders, making the ability to adapt to repeated stress a crucial determinant of mental health. On a molecular level, it remains unclear whether...

biorxiv.org
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🚨Our new #behavior work is out in @Naturemethods! We introduce BehaviorFlow, a pipeline that takes @DeepLabCut tracking and the output of any clustering algorithm to compute the dynamic transitions between behavioral motifs for downstream data analysis 🥳nature.com/articles/s41592-0…

Analysis of behavioral flow resolves latent phenotypes

Nature Methods - BehaviorFlow is a behavioral analysis package that overcomes challenges with multiple testing when dealing with large numbers of behavioral variables and limited availability of...

nature.com
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Oliver Sturman retweeted
Johannes Bohacek@BohacekLab8 Apr 2024
🔵 I've long been fascinated by the impact of #stress on exploratory rearing in mice. Imagine my excitement when our local collaborator @DeBurdakov approached us with these stunning results: #noradrenaline suppresses rearing through MCH neurons & MCHR1!🤩 pubmed.ncbi.nlm.nih.gov/3857…
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🔵 Noradrenaline directly regulates gene expression in the brain. 8 years in the making, now finally published in @eLife 🥳 During revisions, we added 32 RNAseq samples and a meta-analysis of 71 RNAseqs to rule out major sex differences. #stress Please RT elifesciences.org/articles/8…

Noradrenaline release from the locus coeruleus shapes stress-induced hippocampal gene expression

Targeted manipulation of the locus coeruleus noradrenaline circuitry combined with extensive transcriptomic analyses in the mouse hippocampus reveal a unique set of noradrenaline-dependent, stress-...

elifesciences.org
Johannes Bohacek@BohacekLab13 Aug 2023
🚨🔵🚨 Our work on stress-induced gene expression changes mediated by #LocusCoeruleus #noradrenaline has now been reviewed by @eLife !🥳🤩 We got constructive and positive feedback 🙏, and we're tackling those pesky sex effects once more #revisions elifesciences.org/reviewed-p…
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Huge thanks to @Swiss3RCC - our lab's third Swiss 3RCC funding in a row 🥳! Thanks to @osturmscience who leads the 3R efforts in our lab. This funding is allowing us to radically expand the 3R work in our lab. Stay tuned for the launch of a new 3R-Hub @ETH_en ! 🔥
Swiss 3R Competence Centre (3RCC)@Swiss3RCC19 Feb 2024
🎉 We're thrilled to announce the #funding of five #research projects putting #3Rs methods into effective practice! Stay tuned for groundbreaking advancements in research! Read the press release here: swiss3rcc.org/media/pages/ne… #3Rs #replace #reduce #refine #Innovation
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🚨In our latest preprint🚨 we propose a radical change to the analysis of rodent #behavior in preclinical research. Featuring @DeepLabCut ♥️ Check out the manuscript and the 🧵👇 xitter.cf/biorxiv_neursci/status…
bioRxiv Neuroscience@biorxiv_neursci28 Jul 2023
Analysis of behavioral flow resolves latent phenotypes biorxiv.org/cgi/content/shor… #biorxiv_neursci
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Do you remember when you joined Twitter? I don’t but Twitter does… #MyTwitterAnniversary
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1st preprint of the Gapplab! Check out our PROTAC tool to mingle with stress hormone receptor signalling A fun collaborative effort by @Carreiralab @BohacekLab @bel_ethz @Meijer_Lab @GermainPl Lead by stellar students @MGazorpak & Karina Hungentobler biorxiv.org/content/10.1101/…

Harnessing PROTAC technology to combat stress hormone receptor activation

Counteracting the overactivation of glucocorticoid receptors (GR) is an important therapeutic goal in stress-related psychiatry and beyond. The only clinically approved GR antagonist lacks selectiv...

biorxiv.org
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watson.ch/wissen/leben/25292…

Flüssignahrungs-Experte Oliver Sturman hat jetzt eine Slushy-Maschine

Unser jährliches Interview mit unserem liebsten Flüssignahrungsmittel-Experten Oliver Sturman.

watson.ch
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Johannes Bohacek@BohacekLab5 Dec 2022
Serendipity is a huge part of science. This 🧵 tells the story behind our latest preprint, a journey involving #Stress, #Angiogenesis, #Stroke, #Ischemia, #Cancer and a gene you’ve never heard of! biorxiv.org/content/10.1101/…… Kudos to @debocklab who guided most of the work!
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Following the poster session @BohacekLab is taking us through the frontiers in behavioral analysis 🐭 #3Rs #Swiss3RsDay #animalbehavior #animalresearch #animalwelfare #reduction #science #data
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Worried your colleagues aren't excited enough for your next presentation? Build the hype.
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The idea for sci-trailers was born at a lab retreat in 2019. The brilliant @osturmscience then started posting these trailers along with new research from our group. So much fun just putting this list together 😂 Which one is your favorite? The one with the most likes wins!🧵
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Oliver Sturman retweeted
Johannes Bohacek@BohacekLab5 Apr 2022
Our multiomic screen of the changes triggered by acute #stress in the hippocampus is now out in @NatureComm 🥳 Don't miss the wild preprint trailer👇and follow the 🧵 to find out what has changed during the review process. We added (and removed!) a lot! nature.com/articles/s41467-0…

Multiomic profiling of the acute stress response in the mouse hippocampus

Nature Communications - Acute stress can help individuals to respond to challenging events, although chronic stress leads to maladaptive changes. Here, the authors present a multi omic analysis...

nature.com
Johannes Bohacek@BohacekLab27 Mar 2021
🚨PREPRINT ALERT🚨 Our latest work provides a multiomic dissection of the molecular changes triggered by acute #stress. It comes with an interactive app that will make stress researchers jump with joy! Thread and a wild trailer by @Osturmscience below 🔊👇biorxiv.org/content/10.1101/…
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A thin line between genious and crazy #academictwitter @PhDVoice @AcademicChatter
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Trigger warning this meme can trigger painful memories among researchers #academictwitter @PhDVoice @AcademicChatter
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#academictwitter #phdchat #phdvoice #sciencetwitter #AcademicChatter @PhDVoice @AcademicChatter
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Universe cannot be that kind #academictwitter #phdchat #phdvoice #sciencetwitter #AcademicChatter @PhDVoice @AcademicChatter
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