Peter Wang (@propriodon) profile picture

Peter Wang

@propriodon

Postdoc at @MGHCSB, @broadinstitute. @CancerResearch fellow

 Boston, MA
Joined June 2022
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Photo by Peter Wang (@propriodon)Photo by Peter Wang (@propriodon)Photo by Peter Wang (@propriodon)Photo by Peter Wang (@propriodon)Photo by Peter Wang (@propriodon)
Excited to share our preprint on tumor-nerve interactions in pancreatic cancer. Perineural invasion (PNI), a process in which cancer cells invade nerves, is linked to worse outcomes in patients. We define a novel axis by which cancer-nerve crosstalk drives PNI.
Image from Peter Wang (@propriodon)
bioRxiv Cancer Bio (@biorxiv_cancer) profile picturebioRxiv Cancer Bio@biorxiv_cancer31 Aug 2025
The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer biorxiv.org/content/10.1101/… #biorxiv_cancer
The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer

The Pdgfd-Pdgfrb axis orchestrates tumor-nerve crosstalk in pancreatic cancer

Nerves are an integral component of the tumor microenvironment, contributing to cancer progression, metastasis, morbidity, and mortality. In pancreatic ductal adenocarcinoma (PDAC), worse clinical...

biorxiv.org
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Thankful to @DrWilliamHwang, our collaborators @MGHCSB, @MGHCancerCenter, @kochinstitute, @brukerspatial, funding support from @CancerResearch, @thenci, @PanCAN, @Hopper_Belmont, and the patients and families who made this research possible
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Overall this study identifies Pdgfd-Pdgfrb signaling as a key integrator of cancer-nerve crosstalk. Disrupting this axis may offer a new way to halt PNI and its deleterious effects in pancreatic cancer
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Pdgfrb-expressing glia also respond to Pdgfd and physically engage cancer cells during nerve invasion. In vivo, blockade of the Pdgfd-Pdgfrb axis reduces PNI
Image from Peter Wang (@propriodon)
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Mechanistically, Pdgfd drives intrinsic cancer cell invasiveness and extrinsic neurite outgrowth, facilitating increased physical engagement between cancer cells and nerves
Image from Peter Wang (@propriodon)
Image from Peter Wang (@propriodon)
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Pancreatic cancer cells engineered to overexpress Pdgfd invaded nerves more readily and blocking its receptor Pdgfrb reduced neuroinvasion
Image from Peter Wang (@propriodon)
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We leveraged whole-transcriptome and single-cell spatial approaches to integrate molecular coverage and subcellular resolution, converging on Pdgfd signaling as a novel mediator of PNI
Image from Peter Wang (@propriodon)
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Enjoyed catching up over dinner with #JohnHopper and the @Hopper_Belmont #InspirationAwards crew! @propriodon @_Hanna_Hong @Nikita2106
Image from William L Hwang (@DrWilliamHwang)
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A wonderful collaborative effort in the lab by @GongDennis @Ella_Perrault @jwmbae #JeannaQiu just published in Cancer Cell👇tinyurl.com/bdhcbu5t We hope this is a useful resource for anyone interested in #SpatialOncology!
Image from William L Hwang (@DrWilliamHwang)
Image from William L Hwang (@DrWilliamHwang)
Image from William L Hwang (@DrWilliamHwang)
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After a high dose of psilocybin, the brain desynchronizes at a massive scale, causing loss of our sense of self, time, and space. This may drive the burst of plasticity caused by psychedelics. The next day, brain activity has largely returned to normal, but an echo remains – a reset of circuits critical to the sense of self. Our study is out today in @Nature nature.com/articles/s41586-0…
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Great work contributed by @propriodon and other lab members to the just published #CancerNeuroscience 🦀🧠book by @SpringerNature #MoranAmit @nicole_scheff check it out 👉tinyurl.com/bddy2yzb
Image from William L Hwang (@DrWilliamHwang)
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Exercise triggers the release of many hormone-like small proteins from different organs. Some of these proteins have therapeutic effects - thus contributing to our understanding of how exercise improves health. @WuTsaiAlliance cell.com/cell-metabolism/ful…
Image from Satchin Panda (@SatchinPanda)
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Check out this cool video from @propriodon and hear more about his work by registering for the 2nd international Cancer Neuroscience Symposium (2/29-3/1/2024) @MDAndersonNews tinyurl.com/2p7s5m94. Abstracts in @Adv_Biology. @MGHCSB @MGH_RI @broadinstitute @kochinstitute
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Postdoc extraordinaire Peter Wang @propriodon @MGHCSB presenting some of our #CancerNeuroscience work at #AACR2023, abstract 2513, section 6, board 21 from 1:30-5:00 pm. @kochinstitute @LabJacks @broadinstitute
Image from William L Hwang (@DrWilliamHwang)
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