First steps as #psychedelics (DMT) and #consciousness researcher. Chief of Psychedelic and Consciousness Research Group on @SWPSUniversity Neuropsychology š§ š
Warsaw
Joined January 2022
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Jakub Schimmelpfennig retweeted
Sleep pressure in flies is regulated by a rhythmic seesaw between two groups of neurons. This oscillation isnāt just a byproduct of sleep. It helps generate it.
nature.com/articles/s41593-0ā¦
#neuroscience
Jakub Schimmelpfennig retweeted
Big up, Lorenzo and co! onlinelibrary.wiley.com/doi/ā¦
Jakub Schimmelpfennig retweeted
Excited to share this work from the amazing team at @IcahnMountSinai @MountSinaiNYC illuminating the brain dynamics underlying #depression. Major depressive disorder remains one of the leading causes of suffering worldwide. Our new work in @NatureComms uses advanced brain imaging and mathematical modeling to better understand how the depressed brain may become trapped in maladaptive patterns. The ultimate goal of our work is improving #antidepressant #treatment outcome patients.
CHECK OUT the FULL STUDY - "Spatiotemporal asymmetries on brain energy landscape uncover system entrapment related to depression severity" - @ulgenklc, Jenna Jubeir, Priti Balchandani, @JMurrough, Laurel S. Morris & Yael Jacob OUT NOW @NatureCommsš nature.com/articles/s41467-0ā¦
Jakub Schimmelpfennig retweeted
Published in Neurology, "the most widely read and highly cited peer-reviewed neurology journal", on June 9 2026
Results
From a total 248 completed surveys, 100 participants met criteria for cluster headache. Of these, 84% were male and average age was 49 years. The most common place to have learned about DMT treatment was social media/online. More than one mode of ingestion was often tried, but 75% had used a vape pen. Among those who used DMT to abort attacks (n = 85), the majority reported it completely eliminates pain (67.5%) and that it works every (45.7%) or almost every (35.8%) single time. Over half reported that DMT worked in under 30 seconds, and all participants reported either no change or an improvement in their health with DMT use. ā at TepoztlĆ”n, Morelos
Jakub Schimmelpfennig retweeted
How the Unconscious Blocks Distressing Language. Your conscious intuition says you canāt ignore a negative commentābut your nonconscious mind says otherwise.
A new study in Psychological Science reveals that when we are focused on a task, our brains actively filter out and suppress negative spoken words before they ever reach conscious awareness.
Rather than letting threatening language hijack our attention, the brain acts as an automated "cognitive gatekeeper," shielding our limited mental resources from costly, distressing distractions. Interestingly, researchers hypothesize this protective filter might break down in clinical populations dealing with anxiety or PTSD. neurosciencenews.com/unconscā¦ psychologicalscience.org/
#Psychology #Neuroscience #CognitiveScience #BrainResearch #Consciousness #MentalHealth #BehavioralScience
Jakub Schimmelpfennig retweeted
The Allostatic Reset Model (ARM) of Psychedelic Action osf.io/preprints/psyarxiv/hxā¦ via @OsfFramework
Jakub Schimmelpfennig retweeted
CPCR Director @FredBarrettPhD quoted in @AP āItās been incredibly difficult to study ibogaine in the U.S. because of its known cardiotoxicity... If the executive order can pave the way for doing objective, scientific research with this compound, it would help us understand whether it is truly a better psychedelic therapy than others.ā apnews.com/article/ibogaine-ā¦
Jakub Schimmelpfennig retweeted
Adult brains operate near a ācritical pointā of balanced excitation/inhibition, enabling more coordinated rhythms and greater efficiency.
Brain criticality emerges with developmental shifts in frequency-specific excitation-inhibition balance
doi.org/10.64898/2026.03.26.ā¦
#neuroscience
Jakub Schimmelpfennig retweeted
Action potentials are only one layer of brain computation.
quantamagazine.org/once-thouā¦
#neuroscience
Jakub Schimmelpfennig retweeted
New discovery! Different anesthetics all seem to push the brain into unconsciousness in the same way: Activity is destabilized and dominated by slow waves. This could block signals.
cell.com/cell-reports/fullteā¦
#neuroscience @MIT_Picower @mitbrainandcog @mcgovernmit @ScienceMIT
Jakub Schimmelpfennig retweeted
Emerging evidence shows higher cognition relies on rhythmic electric fieldsāacting like "radio waves"āto enable large-scale organization, executive control, and energy-efficient analog computing. Catch Professor Earl K Millerās Presidential Special Lecture at Neuroscience 2025 neuronline.sfn.org/scientifiā¦ @MillerLabMIT
#Neuroscience #Bioelectricity #CognitiveScience #AnalogComputing #SfN25
Jakub Schimmelpfennig retweeted
I read this recently: pubmed.ncbi.nlm.nih.gov/4144ā¦ It says 2A blocker studies often "over-dose the blocker" and thus lose specificity to 2A. Could this apply here? pubmed.ncbi.nlm.nih.gov/3385ā¦
Jakub Schimmelpfennig retweeted
Buzzy times: theguardian.com/science/2026ā¦
Jakub Schimmelpfennig retweeted
Ecodelia and the lost art of lichenthropy - On becoming fungus on acid and on being publicly ridiculed by grass on Salvia
My latest Substack exploring the psychedelic experiences leading folk to connect & communicate with, or transform into other species
davidluke543044.substack.comā¦
Jakub Schimmelpfennig retweeted
Interested in cortical wave dynamics?
Check out our review on the physics, physiology, and psychology of cortical waves led by J Cruddas with @jchrispang
Out now in @NeuroCellPress
sciencedirect.com/science/arā¦
Jakub Schimmelpfennig retweeted
This is significant: nature.com/articles/s41591-0ā¦
Jakub Schimmelpfennig retweeted
There's some wisdom here, perhaps. Absolute outcomes like response and remission may well be better post-approval. On this front, it's almost as if Compass stacked the deck against efficacy so as to "play the game" well. That's a clear contrast vs the Lycos story. It's a good point to end on.
