ratcortex retweeted
【アルツハイマー病の原因物質は、まるで感染症のように脳内で伝染していた】脳の神経変性を引き起こす異常なタウ蛋白が、プリオンのように健康な蛋白を次々と変形させ、脳内で広がる仕組みが構造解析で判明しました。Nature誌 nature.com/articles/d41586-0…
ratcortex retweeted
Alzheimer研究分野に於る2人の重鎮がNatureに論説を掲載
ADはAβ→tauの線形cascadeでなく、<100µmの組織domain毎に閾値(変曲点)を非同期に越えるmozaic過程であり、Aβ関連p-tau誘導(pTau217)が中核的転換点
治療効果は標的の遷移がまだ可逆かで決まる
#Alzheimers
#papers
nature.com/articles/s41586-0…
ratcortex retweeted
Very interesting study - also bringing together a major collaboration to explore how the young versus aging mouse brain tackles a visual decision making task - nature.com/articles/s41467-0…
ratcortex retweeted
タイトルから"意識の理論"の展望論文かと思ったけど，
むしろ，
脳波や神経振動を「メソスケールで実際に計算を担うもの」と位置付け，その働き方を総合的に体系化する"脳の理論"の論文だった
さらに"シナプス/脳波"のハイブリッド理論も提示しており，
確かにmust readだ
jneurosci.org/content/46/33/…
ratcortex retweeted
Thrilled to share that my first postdoc work has been published in @NatureNeuro.
Working with all the brilliant people in the group of Mriganka’s lab and Tim was one of the best things during my postdoc journey!!
nature.com/articles/s41593-0…
ratcortex retweeted
Most neurons seem to be generalists, not specialists. Cortical circuits prioritize diversity over categorical structure.
Rarely categorical, highly separable representations along the cortical hierarchy
nature.com/articles/s41586-0…
#neuroscience
newscientist.com/article/258…
ratcortex retweeted
Amazing work
doi.org/10.1038/s41586-024-0…
ratcortex retweeted
【注目プレスリリース】記憶が「ある」のに思い出せない仕組みを解明 ～脳内ヒスタミン神経のゆらぎが記憶へのアクセスを左右する～ / 名古屋市立大学,北海道大学,熊本大学,科学技術振興機構 research-er.jp/articles/view…
ratcortex retweeted
2024年に生理研で開催して好評だった研究会「大規模脳活動計測〜我々は何を測り､どこへいくのか〜」、今年は遺伝研で開催します！
お申し込み､よろしくお願いします。
kokimura-lab.org/brainactivi…
ratcortex retweeted
Abdominal Movement Flushes Neural Waste
The brain is far more mechanically integrated with the rest of the body than scientists previously realized. In a study, researchers revealed a “hydraulic pump” mechanism that links physical activity to brain health.
When you contract your abdominal muscles, even during a light movement like taking a step, you compress blood vessels that push fluid into the spinal cavity. This pressure causes the brain to gently “sway” within the skull, a motion that acts like squeezing a dirty sponge to flush out toxic neural waste via the cerebrospinal fluid (CSF).
neurosciencenews.com/abdomin…
#neuroscience #science #Exercise (1/3)
