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Temple's first validation study is out. Researchers tested Temple's Brain Flow index head-to-head against Transcranial Doppler (TCD), the gold standard for measuring cerebrovascular function. 23 healthy adults, two challenges: cycling and a standing-to-supine postural shift. The result that stood out most to me: when participants lay down, their heart rate dropped, but their brain blood flow went up. Temple tracked this accurately, right alongside the Doppler. Any device that only measures heart rate would have gotten this completely wrong. Across both challenges, Temple's Brain Flow tracked Middle Cerebral Artery velocity (MCAv) with within-subject temporal correlation of r≈0.8 (p<0.001), which is very high even for medical devices. The paper is posted as a preprint and submitted for peer review. One study, two interventions, healthy adults only, but it's the first step. More validations on Brain Flow, as well as on Entropy with different modalities are underway across the globe. We will keep sharing them as they trickle in. We encourage researchers to replicate this. We'll happily loan Temples to any qualified researcher who wants to pressure-test any of our metrics independently. medrxiv.org/content/10.64898… Cc @agingroy