Sidharth (Sid) Rupani

LAUNCH DAY 🚀 Today I’m launching a new podcast, Hard Drugs, with Jacob Trefethen (@JacobTref) Our first episode is about lenacapavir — a new HIV drug that blocks infections with an efficacy rate of nearly 100%, and which could completely change the fight against HIV worldwide. It’s also about the scientific journey leading up to this point, and how HIV was transformed from a lethal to a manageable condition. 3:52 How was HIV discovered? Where did it come from, and how does it attack the body and cause AIDS? 38:10 Antiretrovirals: How did scientists develop breakthrough HIV drugs — from azidothymidine to protease inhibitors to PrEP? 1:51:35 How does prevention and treatment work today? 2:19:03 HIV’s capsid and the breakthrough of lenacapavir, the first-approved HIV capsid inhibitor 2:50:36 How to develop long-lasting treatments 3:14:45 Lenacapavir’s near 100% efficacy in clinical trials 3:48:40 The impact of global programs against HIV, and can we now end HIV?

Brazil is using Wolbachia in 6 new cities to address a rising dengue outbreak. “We have a list of more than 50 municipalities that have got in touch requesting [‘wolbitos’],” “Our biggest bottleneck right now is the production of mosquitoes.” theguardian.com/global-devel…

A fun new diagram and article I wrote recently. “Why isn't it possible to sum up deaths caused by different risk factors?” This problem is frequently overlooked, which means people don't realise that the same deaths can be prevented in multiple ways. ourworldindata.org/why-isnt-…