@simonsnitz

Synthetic Biology Fellow @harvardmed Genetic sensor engineer

 Boston, MA
simondoelsnitz.com
Joined April 2021
  • Tweets21
  • Following48
  • Followers56
2Media
Our chemical -> biosensor prediction tool, Ligify, just came out in @ACSSynBio ! Give it a spin: ligify.groov.bio Publication here: pubs.acs.org/doi/10.1021/acs…
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Just hit 150 biosensors in groovDB! groov.bio
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Neat video from Research Square about our recent biosensor/ML paper vimeo.com/929916473

Biosensor and machine learning-aided engineering of an amaryllidaceae...

Read the article: https://doi.org/10.1038/s41467-024-46356-y d’Oelsnitz, et al. "Title." Nature Communications (2024) Video produced by https://www.researchsquare.com

vimeo.com
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Our paper on biosensor/ML-aided enzyme engineering just came out! We're one step closer to fermenting the anti-alzheimer's drug Galantamine, rather than harvesting it from daffodils. nature.com/articles/s41467-0… @synbio
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This was a huge TEAM effort. Thank you Danny Diaz and James Loy for creating/implementing MutComputeX, Wantae Kim and Jessie Zhang for enzyme crystallography, Daniel Acosta for HPLC measurements, Tyler Dangerfield for kinetic analysis, ...
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... Matthew Minus for chemical synthesis, James Howard for LC/MS analysis, Mason Schechter & Hannah Do for cloning support, and Hal Alper @alperlab & Andy Ellington for general support/advice.
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Excellent updated review on TetR-family transcription factors. #synbiosensors doi.org/10.1016/j.jsb.2024.1…
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Development of a whole-cell biosensor for ethylene oxide and ethylene biorxiv.org/content/10.1101/…

Development of a whole-cell biosensor for ethylene oxide and ethylene

Ethylene and ethylene oxide are widely used in the chemical industry, and ethylene is also important for its role in fruit ripening. Better sensing systems would assist risk management of these...

biorxiv.org
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Snowprint is out! Find out what specific DNA sequence your biosensor recognizes. #syntheticbiology tinyurl.com/qtdnko snowprint.groov.bio/
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Transcription factor evolution plasmid (pSELIS) is now available on Addgene. addgene.org/202631/

pSELIS-RamR

Plasmid pSELIS-RamR from Dr. Andrew Ellington's lab contains the insert Sh ble and is published in Nat Chem Biol. 2022 Jul 7. pii: 10.1038/s41589-022-01072-w. doi: 10.1038/s41589-022-01072-w. This...

addgene.org
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Preprint of our new tool for predicting biosensor-DNA interactions is out. We use it to discover sensors for a cannabinoid precursor, among others. Check it out! biorxiv.org/content/10.1101/…

Snowprint: a predictive tool for genetic biosensor discovery

Bioengineers increasingly rely on ligand-inducible transcription regulators for chemical-responsive control of gene expression, yet the number of regulators available is limited. Novel regulators can...

biorxiv.org
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Can #synbio help us brew an Alzheimer's drug currently harvested from daffodils? Just got 1 step closer. 🌼🧠🦠 doi.org/10.1101/2023.04.05.5…
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Simon dOelsnitz retweeted
Inyup Paik, Ph.D.@InyupPaik30 Dec 2022
Now we know what is the rate limiting step in LAMP, which will enable even faster diagnosis of diseases via LAMP. academic.oup.com/nar/advance…
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Tired of searching the literature for genetic sensors? Check out our biosensor database (groov.bio), now published in @ACSSynBio doi.org/10.1021/acssynbio.2c…
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Big thanks to Josh Love and @aiproteins for making this possible!
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Just put out a pre-print on a database of genetic biosensors I put together (groov.bio). Hope it's useful to the syn bio / bioengineering community! Feel free to message me with feedback. doi.org/10.1101/2022.07.18.5…
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+1 biosensors, -1 chromatography! My work on evolving biosensors for therapeutic alkaloids is now out in @nchembio rdcu.be/cRb3T #synbio #biotech #biosensor
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Terpenes are hard to measure. Genetic biosensors can help. Here, we evolve biosensors responsive to fragrant monoterpenes. #biotech #synbio #biosensor #directedevolution biorxiv.org/content/10.1101/…

Evolving a generalist biosensor for bicyclic monoterpenes

Prokaryotic transcription factors can be repurposed as analytical and synthetic tools for precise chemical measurement and regulation. Monoterpenes encompass a broad chemical family that are commer...

biorxiv.org
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Recently published in @ACSSynBio ! doi.org/10.1021/acssynbio.1c… #scicomm

Evolving a Generalist Biosensor for Bicyclic Monoterpenes

Abstract. Prokaryotic transcription factors can be repurposed as analytical and synthetic tools for precise chemical measurement and regulation. Monoterpen

pubs.acs.org
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Medicine is starting to be sustainably fermented from sugar rather than synthesized from petroleum. How do we speed up that process? Check out my recent work. #biotech #syntheticbiology biorxiv.org/content/10.1101/…

Using structurally fungible biosensors to evolve improved alkaloid biosyntheses

A key bottleneck in the microbial production of therapeutic plant metabolites is identifying enzymes that can greatly improve yield. The facile identification of genetically encoded biosensors can...

biorxiv.org
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