sophie chabloz retweeted
this needs more attention
A simple blend of glycine, proline, and hydroxyproline is showing a shockingly broad rejuvenation effect.
Humans see visible skin improvements in weeks and an average 1.4 year drop in biological age within 6 months, with extreme responders reversing nearly a decade. 🤯
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When human skin fibroblasts received the 3 Gly:1 Pro:1 Hyp mix, genes related to collagen and the extracellular matrix (ECM) were strongly upregulated within hours.
This suggests the mixture stimulates processes involved in tissue structure and maintenance.
In a small human observational trial:
A group of healthy adults took an oral supplement based on this amino acid mix for 6 months.
Outcomes: improved skin appearance (visible results within ~3 months) and, according to epigenetic / biological age measures, an average 1.4 year reduction in biological age after 6 months.
Just one intervention delivers measurable, cross species rejuvenation signals, hinting at a surprisingly powerful, scalable anti aging pathway.
aging reversal is nearer
very interesting
A simple blend of glycine, proline, and hydroxyproline is showing a shockingly broad rejuvenation effect.
Humans see visible skin improvements in weeks and an average 1.4 year drop in biological age within six months, with extreme responders reversing nearly a decade.
Just one intervention delivers measurable, cross species rejuvenation signals, hinting at a surprisingly powerful, scalable anti aging pathway.
sophie chabloz retweeted
Here's a link to the study for those interested.
nature.com/articles/s41514-0…
sophie chabloz retweeted
Supplementing the three primary collagen amino acids glycine, proline, and hydroxyproline in a 3:1:1 ratio produces consistent, measurable benefits across worms, mice, and humans.
In humans, skin outcomes (wrinkles, texture, elasticity, and hydration) improved 4–6% within 1–3 months.
The most striking result was a reduction in biological age by an average of 1.4 years after 6 months, with maximum reductions of 8.9 years in men and 12.1 years in women. Those with a biological age higher than their chronological age saw the largest improvements.
In C. elegans, the 3:1:1 mix increased lifespan 6–27% (greater than whole collagen). In old mice, it preserved grip strength and reduced white adipose tissue.
Glycine, proline, and hydroxyproline form the backbone of collagen and play roles in protein synthesis, one-carbon metabolism, and likely signaling pathways that influence tissue maintenance and repair.
These animal and human data together provide a compelling translational story.
