Our lab studies blood pressure: let’s work together to bend the curve toward better health
The interface of organ systems
Joined December 2015
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J. Brian Byrd Lab retweeted
RESEARCH ARTICLE: Dietary Sodium-Regulated Plasma SVEP1 and Inverse Salt Sensitivity @thebyrdlab
ahajrnls.org/3RA1Pao
J. Brian Byrd Lab retweeted
Here are 10 randomized trials I'd love to see (share links if they've been done!):
1. Potassium repletion to >4.0 vs 3.5 or 3.0 in hospitalized medical patients
2. Treatment vs observation for hypertensive urgency
3. Iron supplementation (likely IV) vs placebo for anemia of chronic inflammation
4. Diazepam vs Lorazepam (both symptom-triggered) for alcohol withdrawal
5. Symptom-triggered benzos versus phenobarbitol for alcohol withdrawal
6. NSAIDs vs opioids for acute pain in CKD 3+
7. NSAIDs vs opioids for acute pain in AKI
8. Transfusing for a hemoglobin <7 g/dL vs < 6g/dL (or lower) in hospitalized medical patients
9. Tranfsusing for a hemoglobin <7 g/dL vs for symptoms in hospitalized medical patients
10. IV furosemide vs PO torsemide for acute on chronic heart failure
What would you like to see?
J. Brian Byrd Lab retweeted
A leading AI in medicine researcher and a leading biostatistician explain why we need more randomized clinical trials in AI and why these are so challenging. @nejm_AI ai.nejm.org/doi/full/10.1056… Essential reading for those striving to bring urgently needed AI assistance into clinical care.
J. Brian Byrd Lab retweeted
🥳Proud to be part of this RCT led by Anthony Rodgers from @georgeinstitute
"A novel ..#SPC ..of telmisartan, amlodipine, and indapamide provided clinically meaningful improvements in #bloodpressure ..compared with dual combinations ..well tolerated"
thelancet.com/journals/lance…
J. Brian Byrd Lab retweeted
You encounter a woman with HTN and hypokalemic metabolic alkalosis. First move? Renin and Aldo, Genetic testing, U chloride, Renal artery imaging, better history? The answer is always history. Huge kudos to prior @Rush_Nephrology fellow @MeloneyOliveira for making the diagnosis!
J. Brian Byrd Lab retweeted
Does aldosterone affect the heart before primary aldosteronism (PA) develops? PA biomarkers linked to increased LV mass index by age 27, even w/o overt disease.Early detection could reshape treatment! @moragjyoung @markus_schlaich @RoshanAnanda2 @DrJunYang ahajournals.org/doi/abs/10.1…
J. Brian Byrd Lab retweeted
Join Drs Mulatero and Brown as they debate #PrimaryAldosteronism detection - formal testing vs empiric treatment @TheEndoSociety #CEU now. images.app.goo.gl/3Ne6WXEjaz…
J. Brian Byrd Lab retweeted
Would be interesting to make a survey to ask nephrologists (at least), if SPRINT changed the way BP is measured. And what are their limitations? #nephjc
J. Brian Byrd Lab retweeted
Individualization of targets and all is fine
But it’s mostly used by doctors as excuses to
- not measure BP properly
- escalate BP therapy properly
Use RASi and thiazides in your CKD folks
Don’t panic over creatinines
Stop making excuses!
#NephJC
J. Brian Byrd Lab retweeted
ESCAPE-SALT study showed acute salt intake impaired micro vascular function in retinal vessels that maybe negated by KCl. Super intriguing results @CouncilonHTN #Hypertension24
J. Brian Byrd Lab retweeted
Lots of interest in primary aldosteronism at #Hypertension24
If you enjoyed our PA session then you should also watch this seminar
Did you miss our most recent 12/12/23 #HypEdSeries Webinar, "Primary Aldo: Screening and Interpretation" presented by Anand Vaidya and Adina Turcu? No problem! Follow the link below to watch the replay and get your AHA Lifelong Learning credit today!
ahajrnls.org/3SucO1S
J. Brian Byrd Lab retweeted
Great talk by Dr Jennifer Brown that we should not call “confirmatory testing” but “aldosterone suppression testing as they are far from perfect to confirm and results are not consistent. #Hypertension24
J. Brian Byrd Lab retweeted
It is a pleasure to discuss #Hypertension24 program innovation with @KChurchwellMD and Dr. Thu le Program Highlights Hypertension 2024 youtu.be/ZLwj-PjABz0?si=Loo8… via @YouTube @CouncilonHTN
J. Brian Byrd Lab retweeted
Outstanding talk on role of aldosterone synthase inhibitors vs nsMRA and sMRA on BP by @ljlaffin #Hypertension24 @CouncilonHTN @AHAScience
J. Brian Byrd Lab retweeted
Starting #Hypertension2024 with Dr. Harrison’s masterclass talk on the immune mechanism of hypertension. Looking forward to the discussions on this topic during the upcoming poster sessions! @endocelldoc
J. Brian Byrd Lab retweeted
Opening session #Hypertension24 @AHAScience By @KChurchwellMD loaded with exciting programs. couldn’t be possible with all leaders @CouncilonHTN
J. Brian Byrd Lab retweeted
Huge thanks to our conference leadership for assembling an amazing program! #Hypertension24 @AHAScience @AHAMeetings
@DrWanpen
J. Brian Byrd Lab retweeted
Thrilled to share our latest preprint, the result of an incredible collaboration between the @Salic_Lab , @MdBreault, and @DrGaryHammer labs, alongside amazing collaborators. Honored to co-lead this with Donald Little and @TaciAMagalhaes 🧵
biorxiv.org/content/10.1101/…
