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https://xitter.gq/t.co/qswrK5cWNk https://xitter.gq/t.co/mkKAtf44PR https://xitter.gq/t.co/sDJ1ibevTw

Joined January 2018
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Vulkaron of Tartaria retweeted
PCVX / VAX-31 OPUS-1 topline is due by end of October. Vaxcyte's OPUS-1 is the one I'm tracking this month. In their 8-K on Sept 3 they narrowed topline from "Q4" to "by the end of October." OPUS-1 dosed 4,049 adults aged 50+ and compares VAX-31 head-to-head with both Prevnar 20 and Capvaxive. The checklist is built from their own high-dose Phase 1/2 result, since that's the dose that went into Phase 3: floor: all 20 serotypes shared with PCV20 meet non-inferiority (lower bound of the GMR CI > 0.5) bar: at least 18 of 20 with a GMR above 1.0, and all 11 VAX-31-only serotypes meet superiority upside: shared serotypes with a statistically higher response (lower bound > 1.0) For reference, the Phase 1/2 middle dose was 20/20 non-inferior but only 13/20 above 1.0. That's what "clears the floor, misses the bar" would look like. The low dose missed non-inferiority on 2 of 20. Honestly, there's a lot this can't score. There's no prior VAX-31 vs Capvaxive number anywhere, so I have no threshold for it, and I think that's where the real debate is. The margins come from the Phase 1/2 definitions, not a Phase 3 analysis plan. Safety was only ever described in words ("similar to PCV20"). They also had $2.5B in cash at 6/30, so I didn't treat financing as a factor. The full checklist, the sources and its SHA-256 fingerprint are here, free: catalystintel.io/events/PCVX…. I'll post the grade in this thread when the data comes out, pass or miss. Not advice. If you think a threshold is set wrong, I'd like to hear why 🙏
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Vulkaron of Tartaria retweeted
$IVVD — Invivyd’s VYD2311: topline results in COVID-19 pre-exposure prophylaxis, expected October 2026. Before the readout, we wrote down what a good result has to show, and sealed it. The full bar, with a source for every line: catalystintel.io/events/IVVD… What’s coming In Invivyd’s own words (8-K, Sep 29, 2026): “DECLARATION sVNA titers, PK, and safety data expected in October 2026; COVID-19 events to remain blinded and DECLARATION planned to serve as the ongoing, confirmatory trial” What we locked 2 lines: 1 minimum that must be met; 1 target that sets the bar. Each quotes a company document. Subscribers have the numbers now; they open to everyone 30 days after the readout. What happens next When the results print, the verdict lands in this thread: every reported number beside the sentence it came from, measured against the bar as sealed. Beat, in line, thin or miss. Arithmetic, not opinion. Proof it was written first SHA-256 13f46bbcf995a82f3d6eb21cc6c5c02936aa8734e66f307a9a93ac8564f10b7a Once the bar opens, anyone can recompute this fingerprint from its text. #Biotech Research, not advice. Not an RIA. Positions: none.
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Vulkaron of Tartaria retweeted
$KOD — Kodiak Sciences’ KSI-101: topline results in Macular edema secondary to inflammation (MESI), expected December 2026. Before the readout, we wrote down what a good result has to show, and sealed it. The full bar, with a source for every line: catalystintel.io/events/KOD-… What’s coming In Kodiak Sciences’ own words (8-K, Sep 28, 2026): “We also remain on track to announce topline data in December 2026 for KSI-101 in the Phase 3 PEAK study in patients with macular edema secondary to inflammation (MESI), in which KSI-101 is being evaluated for superiority against sham-treated patients.” What we locked 4 lines: 1 minimum that must be met; 1 target that sets the bar; 2 extras that would make it a beat. Each quotes a company document. Subscribers have the numbers now; they open to everyone 30 days after the readout. What happens next When the results print, the verdict lands in this thread: every reported number beside the sentence it came from, measured against the bar as sealed. Beat, in line, thin or miss. Arithmetic, not opinion. Proof it was written first SHA-256 11987fd3719caf576d6019b042d6758a5e06c84ad1ae7db01084c5391f36220b Once the bar opens, anyone can recompute this fingerprint from its text. #Biotech Research, not advice. Not an RIA. Positions: none.
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Vulkaron of Tartaria retweeted
RespectASO v2.27.0 is out. 🌍 ASO research across all 175 App Store storefronts, up from 30. Also new: • Opportunity Finder runs in the background so you can navigate the tool as you want while it is running the simulator. • Opportunity scores now estimate even more realistic downloads. • 5 clearer keyword tags (updated from previous versions) • More reliable AI research Enjoy! 🥳
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Vulkaron of Tartaria retweeted
$PCVX - Vaxcyte's VAX-31: Phase 3 topline results in adult pneumococcal disease, expected October 2026. Before the readout, we wrote down what a good result has to show, and sealed it. The full bar, with a source for every line: catalystintel.io/events/PCVX… What's coming : Vaxcyte says topline safety, tolerability and immunogenicity data from the adult Phase 3 OPUS-1 trial are "now expected by the end of October", narrowing earlier guidance of the fourth quarter. (8-K, Sep 10, 2026) What we locked: 3 criteria: the primary immunogenicity endpoints, the non-inferiority margin, and safety. Each quotes a company document. Subscribers have the numbers now; they open to everyone 30 days after the readout. What happens next : When the results print, the verdict lands in this thread: every reported number beside the sentence it came from, measured against the bar as sealed. Beat, in line, thin or miss. Arithmetic, not opinion. Proof it was written first: SHA-256 7497f8b0abfee8cac8baf9d1906706d0333c82f8ba7aca36298bc84c8ac5c0e1 Once the bar opens, anyone can recompute this fingerprint from its text. #Biotech Research, not advice. Not an RIA. Positions: none.
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Vulkaron of Tartaria retweeted
RespectASO automates ASO for iOS on macOS: agentic AI finds keywords, scores difficulty, analyzes competitors and auto-generates validated metadata that self-corrects to follow App Store rules. #ASO #iOS #AgenticAI
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Vulkaron of Tartaria retweeted
RespectASO v2.22.0 is out! 🥳 And it comes with some major updates! And here is the list of major updates and new features in this release: Apple's search data, now through Apple's official API: - - - The Apple Ads popularity source has been rebuilt on Apple's new official Apple Ads Platform API. The sign-in window is gone: connecting is a one-time, five-minute API key setup - no campaigns, no spend, no payment method - and your key never leaves your computer. - Official weekly data. RespectASO syncs Apple's official top search terms per storefront and category every week, automatically. Keywords Apple reports get Apple's own 1–100 value; the rest are covered by the estimate, clearly labeled. - Works everywhere. The Apple source now works in the desktop app, the browser edition, and Docker - it was native-Mac-only before. - Faster scoring. After the weekly sync, every popularity lookup is instant and local - scans and analyses no longer wait on Apple. Top Search Terms - a new Pro tab: - - - Browse what people actually search on the App Store: Apple's official most-searched terms per storefront and category, with rank, popularity, and Apple's 1–5 tier. - See the weekly climbers, fallers, and brand-new terms at a glance. - Follow any term's week-by-week history with sparklines and a full chart. - Track any term for the app you choose, or send it straight to the AI Researcher - one click each. - If you run Apple Ads campaigns, your ads' impression share per search term appears on the dashboard. A smarter, measured estimate: - - - The built-in popularity estimate has been recalibrated against hundreds of Apple's official values, so both sources now speak the same 1–100 scale and popular brand keywords are recognized far more reliably. Your keyword history is re-scored automatically so everything stays comparable - expect the numbers to shift once, by design. Every popularity badge now explains itself on hover: which source produced the number, and exactly how it was derived. Use any AI model, from any provider: - - - OpenAI, Anthropic, and Google Gemini now work like OpenRouter already did: type any model ID the provider offers, run the built-in test, and it's ready - new models work the day they ship, no app update needed. A new AI response deadline (Settings, default 60 minutes) stops a stalled model from eating your afternoon, and the progress view now shows elapsed time and warns when a model is responding unusually slowly.
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Vulkaron of Tartaria retweeted
The next release of RespectASO will be benefiting a lot from the new Apple Ads Platform API as well. Users will be able to select any of internal popularity estimations and estimations from AAP API. AAP API does not cover ALL the keywords though, it comes with some limitations. But whenever a keyword is missing in AAP API, RespectASO's own popularity estimation will be presented. And, RespectASO's popularity estimation is also being updated in the next release. The next release will be out this week.
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Vulkaron of Tartaria retweeted
RespectASO - I built a free, open-source, self-hosted ASO tool for App Store. Link to the repo (with instructions on how to use it) in the comments below. WHY FREE & WHY OPEN-SOURCE? What any ASO tool gives you are just algorithmically calculated estimations. I have tried many and often ended up being disappointed. And I can say they are not consistent at all. I feel like they probably over-complicate things in their solutions where over-complication does not necessarily create a better solution. This tool has its own logic for finding popularity and difficulty, and it comes with additional insights which is not available in other tools I tested, i.e. how hard it is to rank in Top 5, Top 10 and Top 20 in the search results for a given search term in a given country. And it helps finding the best country to rank for a given keyword. WHY SELF-HOSTED? I wanted to provide this as free. If I hosted the whole thing at a site, I suspect that abuse would be one of the things I would need to deal with, and it would also come with lots of infrastructure costs. And users would share their data suspecting how the hack this is possible for free of charge. Hosting locally is extremely easy, can be done in less than 2 minutes. HOW IT WORKS IN A NUTSHELL? It uses the public iTunes Search API to estimate keyword popularity (6-signal model), difficulty (7 weighted factors), and downloads per ranking position. You can scan 30 App Store countries, track your app's rank, and export to CSV. It has all the core functions one can ask for.
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Vulkaron of Tartaria retweeted
When the cards come to life, the gods go to war. Nomos, Katabasis, or Kinesis—your strategy defines the victor. fatesofolympus.com/ Join the adventure now! #FatesOfOlympus #GameDev #CardGame #MagicTheGathering
🤖 Made with AI
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Vulkaron of Tartaria retweeted
Data Has Become a "Toxic Asset" (The California DROP Factor) The most urgent shift in 2026 is that holding user data now carries a direct financial penalty. With the California Delete Act and the launch of the DROP platform on January 1, 2026, consumers can wipe their data from hundreds of brokers with a single click. The Risk: If your analytics tool retains linkable user profiles, you may be classified as a data broker. You would then be legally required to build complex deletion APIs or face fines of $200 per request, per day. Respectlytics turns this liability into an asset. Because the "Return of Avoidance" architecture (RAM-only, rotating IDs) never creates a permanent user profile, you have no data to delete. You are architecturally exempt from the operational nightmare of DROP, saving your clients legal headaches and infrastructure costs. App owners should genuinely cares about this? #privacymatters
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Vulkaron of Tartaria retweeted
🚀 Excited to announce my latest community-powered project for Cursor users: cursorai.info 🎉 Unlike other sources, here you can discover & generate the best Cursor rules tailored to your specific goals — not just your tech stack. Give it a spin and level up your workflow!
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Vulkaron of Tartaria retweeted
Spent a few hours exploring Cursor rules and ended up building a site for it over the weekend! 🚀 Thanks to Cursor, it only took 2 days. cursorai.info now helps you find rules based on INTENTION, not just tech stack — plus, there’s an AI assistant inside. Give it a spin and boost your workflow!
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Vulkaron of Tartaria retweeted
After a great product launch at Product Hunt, my servers literally crashed due to heavy load... 😅 Will I give up..? Dumb question.. Of course, not! 😎 Client Tracer is indeed a great product that many can benefit from, including myself! 😊 #Lead #LeadGeneration #Sales
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Vulkaron of Tartaria retweeted
🚀 Just upgraded #RapidEmailVerifier 👉Powerful alias detection for major email providers 👉New domain verification algorithm makes batch validations up to 9x faster 🛠️Identify mailboxes more accurately 💵All FREE and open source Try it now rapid-email-verifier.fly.dev
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Vulkaron of Tartaria retweeted
Client Tracer ( clienttracer . com) is live! #USA #AI #sales
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Vulkaron of Tartaria retweeted
I proudly present my latest pain killer open source project for indie hackers and solopreuners : 👉Free 🛡️Privacy First 🌍Open Source 📨Fast Email Verifier rapid-email-verifier.fly.dev… @IndieHackers
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Vulkaron of Tartaria retweeted
#AlexanderTheGreat Latest update 🚀 Game mechanics are almost done. Not it is time to start working on marketing, monetization and i18n.
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Vulkaron of Tartaria retweeted
Each new product I launch is a new excitement. I am executing on my strategy to develop new Web apps this year. Client Tracer will be the next one. Not much time left before the launch.. #LeadGeneration #Distribution #AI #Marketing #Sales
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