Emory Neuroscience PhD student . . . 🧠🧐. . . . coadvised @emoryalvarezlab 🐭 & Sam Sober 🐔 he/him
Atlanta, GA
Joined October 2017
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I'm super excited to get this awesome dataset into the world, congratulations to @JasmineDickinso
biorxiv.org/content/10.64898…
William McCallum retweeted
I'm so excited to share our new preprint!
Why can just minutes of motor cortex stimulation relieve chronic pain for weeks, while opioid drugs typically relieve pain for only hours?
To understand this mechanism, we backtranslated TMS treatment to mice: tinyurl.com/mtcderzv
William McCallum retweeted
Excited to share our new paper in @SfNJournals exploring how microglial TREM2 influences BOTH degeneration and regeneration after peripheral nerve injury.
We found that microglia respond very differently depending on the state of the injured motoneuron.
jneurosci.org/content/46/20/…
William McCallum retweeted
🚨‼️Preprint Alert‼️🚨
Hot off the press! We report a dual role for TREM2 following PNI; both beneficial for axon regeneration and detrimental to motoneuron preservation. Very glad to see the bulk of my dissertation work finally out! @emoryalvarezlab biorxiv.org/content/10.1101/…
Congratulations to @K_Thomas1122 on this awesome study - motor units recorded during locomotion using @CAMBER_Atlanta technology !
Motor unit mechanisms of speed control in mouse locomotion biorxiv.org/cgi/content/shor… #biorxiv_neursci
Brand new (10 years running…) work from the @emoryalvarezlab out today - it’s a neuroanatomy feast. Joining the lab and seeing this take its final form I knew I was in the right place. The whole team is legendary!! (and V1s are the coolest)
elifesciences.org/articles/9…
Latest paper from the @emoryalvarezlab , which I'm grateful to have been able to contribute to, and got me started on my current love affair with motoneurons
biorxiv.org/content/10.1101/…
Congratulations Dr. @ebethsypek on this publication - I am extremely grateful for the one of a kind mentorship of the legendary Dr. @ebethsypek and for the chance to contribute to this work. To this day I use your custom tools for handling my spinal cord sections!!
Now in #PAIN: “Diversity of microglial transcriptional responses during opioid exposure and neuropathic pain” by Sypek et al. bit.ly/3YhVpxG
few things break my conceptual tunnel vision nowadays but this is one! Awesome work by @jennisisaac , and a highly recommended read regardless of your field of interest
Spent the past few years with @muruganmalu studying what drives affiliative social interactions in 🐭 & now you can read some of our thoughts in @TrendsNeuro 🧠
William McCallum retweeted
Come see the next generation of high-resolution #EMG tools at #SfN2024!
➡️Booth 1869⬅️
CAMBER (camber.emory.edu) provides EMG (“Myomatrix") arrays to the global neuro community
Example motor unit recordings in forelimb (mouse), vocal (rat), and hand (human) muscles:
Massive congrats to @chenchong446337 and the whole team for this project - it was awesome to be in the lab as they developed these ideas and I’m glad to see it out for the world!!
The discovery of a brain circuit involved in the pain-relieving effect of placebos could lead to new treatments go.nature.com/4desNdd
Love to see credit where credit is due!! Tana is a serious force in the lab and an excellent mentor, take a minute to read i to her ongoing work @PottorfTana @emoryalvarezlab
Each year, the Dept of Cell Biology recognizes an outstanding undergraduate, graduate, or post doc learner. Meet 4th year neuroscience PhD candidate Tana Pottorf-Nitcher working in microglia-motoneuron interactions in the spinal cord after injury. More ➡️ brnw.ch/21wIQhM
A freshly printed poster will always make your day! thank you to @K_Thomas1122 for teaching me EMGs so I can make a giant poster with my recordings
The Alvarez lab is very proud of our graduate student @willieneuro for his presentation on tools for high res EMG's at the Sensorimotor Circuits for Limb Control meeting @OISTedu this past March, and additional presentation @EmoryUniversity @emoryDSAC GDBBS Research Symposium.
William McCallum retweeted
➡Olivia C. Mistretta et al. present novel methods to study neonatal air-stepping in newborn mice in this newly published research.
🖱 ow.ly/nbpx50QLIjF
@LabLerit #AirStepping #neonates #kinematics #RhythmicLocomotion
William McCallum retweeted
Looking for a high-resolution readout of motor neuron activity to study fine details of behavior?
Check out what you can do with @CAMBER_Atlanta #myomatrix arrays and our Acquisition Board in this blog post.
open-ephys.org/blog/2024/3/2…
William McCallum retweeted
Modulation of central synapse remodeling after remote peripheral injuries by the CCL2-CCR2 axis and microglia dlvr.it/T2y4X5
When @emoryalvarezlab hired me I said that staining for regenerated spindle fibers in muscles was a dream project… it was and now its out in press!! Hugely grateful to the team and everyone involved, but most importantly to my long time mentors @7867Mercer @ebethsypek thank you
We are excited to share the following publication which was a joint effort with the Cope lab @GeorgiaTech Herein, we elucidate the differing effects on spinal cord plasticity and inflammation between crush and cut peripheral nerve injuries.
🧵
cell.com/cell-reports/pdfExt…
William McCallum retweeted
A new device called Myomatrix improves the way scientists can record the activity of motor units in a wide range of animals and settings. elifesciences.org/articles/9…
ALT Myomatrix recordings across muscles and species.
Even though it’s from my own lab I have been waiting for this to drop!! @aeworthy leading this epic project like a boss
SPINAL V1 INHIBITORY INTERNEURON CLADES DIFFER IN BIRTHDATE, PROJECTIONS TO MOTONEURONS AND HETEROGENEITY biorxiv.org/cgi/content/shor… #biorxiv_neursci
William McCallum retweeted
Emory University and @GeorgiaTech received a $4.8 million grant from the National Institutes of Health (@NIH) BRAIN Initiative to establish a center to make and globally distribute next-generation micro-technologies for neuroscience. links.emory.edu/Fq