Aaron Wong (@wongak) header
Aaron Wong (@wongak) profile picture

Aaron Wong

@wongak

VP Informatics @SimonsFdn

 New York, NY
humanbase.io
Joined February 2009
  • Tweets85
  • Following567
  • Followers113
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Photo by Aaron Wong (@wongak)
HumanBase: an interactive AI platform for human biology nature.com/articles/s41592-0…
Image from Nature Methods (@naturemethods)
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Aaron Wong retweeted
Mark (@Sanbomics) profile picture
Mark@Sanbomics13 Aug 2023
RNAseq counting tools are not perfect. I simulated 240 GTEx samples to test multiple tools. Below I show the difference between actual and estimated counts for each simulated sample. But, what is causing this? And will it affect differential expression? (1/7) #Bioinformatics
Image from Mark (@Sanbomics)
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The 2022 Simons Foundation Annual Report is now available online! Check out some of our program highlights from the past year and read about our love for the city we call home - NYC. annualreports.simonsfoundati…
A light blue collage-illustration of NYC buildings and landmarks.

ALT A light blue collage-illustration of NYC buildings and landmarks.

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Please no
Image from Aaron Wong (@wongak)
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HumanBase is an online interactive resource for human gene expression and protein interactions in different tissues, check your gene of interest today: hb.flatironinstitute.org/ @HumanBaseFI @SFARIorg
Image from Simons Searchlight (@s_searchlight)
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Decoding disease: from genomes to networks to phenotypes go.nature.com/3fq7VnT #Review by @wongak, Rachel S. G. Sealfon, Chandra L. Theesfeld & @OlgaTroyanskaya @TroyanskayaLab @FlatironCCB @FlatironInst @Princeton @PrincetonHive
Decoding disease: from genomes to networks to phenotypes

Decoding disease: from genomes to networks to phenotypes

Nature Reviews Genetics - In this Review, the authors discuss computational methods for interpreting the molecular and clinical effects of genetic variants. They focus on methods leveraging machine...

nature.com
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Check out humanbase.io - from tissue-specific networks to mutational regulatory impact to disease gene prediction. Project lead by the amazing @wongak Nicely described in simonsfoundation.org/2020/11… @SimonsFdn @FlatironInst @FlatironCCB
Finding Signals in the Noise With HumanBase

Finding Signals in the Noise With HumanBase

What once seemed impossible — sequencing an entire genome — is now fast, routine and cheap. With sequences from hundreds of thousands of human genomes now available to scientists, as well as growing…

simonsfoundation.org
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thrilled to be a part of this collaboration and apply our cell-type specific networks at @HumanBaseFI to COVID-19.
Abhijit (Jeet) Naik (@minimalchange) profile pictureAbhijit (Jeet) Naik@minimalchange7 Oct 2020
SARS-CoV-2 receptor networks in diabetic and COVID-19 associated kidney disease kidney-international.org/art… . @MiKTMC @UMichKidney @umichmedicine @Berthiercc @OlgaTroyanskaya .
SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease

SARS-CoV-2 receptor networks in diabetic and COVID-19–associated kidney disease

COVID-19 morbidity and mortality are increased via unknown mechanisms in patients with diabetes and kidney disease. SARS-CoV-2 uses angiotensin-converting enzyme 2 (ACE2) for entry into host cells....

kidney-international.org
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Instead of fireworks extravaganzas this July 4, I think a lot of people would feel the American idea were more meaningfully celebrated if cities put that money into social programs that lasted longer than a few minutes and left people truly better off. While panicking zero dogs.
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Thoughtful statement by Princeton U President-I am an alum/believe wise decision/“I opposed taking Woodrow Wilson’s name off our school. Here’s why I changed my mind. - The Washington Post washingtonpost.com/opinions/…
Opinion | I opposed taking Woodrow Wilson’s name off our school. Here’s why I changed my mind.

Opinion | I opposed taking Woodrow Wilson’s name off our school. Here’s why I changed my mind.

Princeton honored Wilson without regard to, and perhaps even in ignorance of, his racism. And that was the problem.

washingtonpost.com
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Image from Jeff Atwood (@codinghorror)
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SARS-CoV-2 receptor networks in diabetic kidney disease, BK-Virus nephropathy and COVID-19 associated acute kidney injury medrxiv.org/cgi/content/shor… #medRxiv
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The Viral ‘Study’ About Runners Spreading Coronavirus Is Not Actually a Study vice.com/en_us/article/v74az… via @vice
Aaron Wong retweeted
Jian Zhou (@zhou_jian) profile picture
Jian Zhou@zhou_jian4 Dec 2019
Hi genomics community! I recently started my own group at UTSW. We are looking for postdoc and students interested in machine learning and genomics to join us in our adventures in new frontiers! Please RT or forward to any potential interested candidates zhoulab.io/home#join-us
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Our latest paper on noncoding contributions in #autism using deep learning models is out in @NatureGenet. De novo noncoding variants contribute to # of cases comparable to coding. With @darnelr @zhou_jian @pazpark @chandralt4 @simonsFdn @princeton #WGS rdcu.be/bEAto
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Proud of our discovery of noncoding regulatory signal in autism. Independently confirmed in discovery and replication cohorts for both DNA and RNA regulation. #deeplearning #WGS #autism #ASD biorxiv.org/content/early/20…
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Whole-genome deep learning analysis reveals causal role of noncoding mutations in autism biorxiv.org/cgi/content/shor… #bioRxiv
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.@ngehlenborg demonstrates HiGlass.io, a web-based tool for exploring genomic contact matrices and tracks #VIZBI (preprint at biorxiv.org/content/early/20…)
HiGlass

HiGlass

Web-based visual exploration and comparison of Hi-C genome interaction maps and other genomic tracks

higlass.io
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.@wongak from @FlatironInst presenting HumanBase (hb.flatironinstitute.org/), a data-driven compendium of tissue-specific functional genomic info with a great interface and visualizations #vizbi
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.@OlgaTroyanskaya: NetWAS integrates #GWAS results & tissue-specific network data hb.flatironinstitute.org/net… #neurogen17
Image from Brooke LaFlamme (@Brooke_LaFlamme)
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