Prioritizing and Strengthening the Subspecialty of Traumatic Brain Injury and Neurocritical Care

Single-cell RNA Sequencing Analysis Reveals That Targeting PLG–PLGRKT Signaling-mediated Pro-fibr...

Biliary atresia (BA) is a severe pediatric cholangiopathy characterized by rapidly progressive liver fibrosis. This study aimed to characterize scar-associated macrophages and investigate the role of...

Tarlatamab Treatment for Metastatic Small Cell Neuroendocrine Carcinoma of the Breast: A Case Report

Since their first inception, neuroendocrine neoplasms of the breast have undergone many iterations of classification and definition. Taken together with their extremely low incidence, the ever-evol...

PharmacoGWAS for Drug Response: Study Design, Phenotype and Exposure Definition, Bioinformatics...

Inter-individual variability in drug efficacy and toxicity remains a major obstacle to precision therapeutics. Candidate-gene pharmacogenomics and star-allele-based guidelines have established...

Entecavir plus Fuzheng Huayu Compound Reduces the Risk of Portal Hypertension-related Complications...

Fuzheng Huayu, a patent herbal product, has shown promise in liver fibrosis and cirrhosis. The effect of Fuzheng Huayu on portal hypertension due to cirrhosis and the consequent complications needs...

Colorectal Cancer Screening Pathways and Regional Prevention and Control in Primary Healthcare

Colorectal cancer is a major cause of cancer morbidity and mortality worldwide, including in China. Screening can facilitate earlier detection and reduce disease burden, while primary healthcare...

Increasing Cholangitis-related Mortality and Persistent Disparities Among U.S. Adults, 1999–2023

Selective Balloon-occluded Transarterial Chemoembolization for Hepatocellular Carcinoma: Mechanis...

Balloon-occluded transarterial chemoembolization (B-TACE) has emerged as a significant advancement in the locoregional treatment of hepatocellular carcinoma. This technique utilizes a balloon...

Enhancing Cross-dataset Zero-shot Generalization in Colorectal Polyp Detection Using Vision-langu...

Colorectal polyp detection from endoscopic images is critical for the early diagnosis of colorectal cancer. However, traditional deep learning methods often suffer from limited generalization when...

Evaluation of Human Serum Albumin in Neurocritical Care: A Narrative Review of Current Applications...

Human serum albumin (HSA) is a multifunctional carrier protein that helps maintain vascular barrier integrity and intravascular fluid homeostasis and has long been used in the management of critica...

Solvent Matters: A Call for Rigorous Consideration of Organic Co-solvents in Drug-target Interact...

Arterial Spin Labeling in Neurosurgical Practice: Emerging Applications and Translational Challenges

ESR1 Testing in the Era of Precision Oncology: A Mini Review

Estrogen receptor alpha, encoded by the ESR1 gene, is a major oncogenic driver in hormone receptor-positive/HER2-negative breast cancers. While endocrine therapies are effective in treating this...

The CYB5R3–mARC1 Redox Axis in Metabolic Dysfunction-associated Steatotic Liver Disease: Mechanis...

Metabolic dysfunction-associated steatotic liver disease affects roughly 38% of adults, yet approved agents do not correct the upstream redox-metabolic perturbations—a depressed nicotinamide adenine...

Redox Remodeling as a Natural Product Strategy in Cancer Therapy: Lessons from Arnicolide C

Perspectives on Cancer Immunotherapy Discussed at a 2025 Symposium in Cuba

Increased Susceptibility to Hepatic Ischemia–reperfusion Injury in MASLD: A Mini Review

Metabolic dysfunction-associated steatotic liver disease (MASLD) is increasingly prevalent worldwide and is frequently encountered in patients undergoing liver transplantation and hepatic surgery....

Transradial versus Transfemoral Access for Intracranial Aneurysm Embolization: A Narrative Review...

Endovascular embolization is a cornerstone treatment for intracranial aneurysms, and transfemoral access (TFA) has traditionally been the default vascular route. Transradial access (TRA) is increas...

Undifferentiated Pleomorphic Sarcoma with a Likely Nonfunctional EWSR1::NF2 Fusion and Complex...

EWSR1 fusions are recurrent genetic alterations in a wide spectrum of mesenchymal tumors and are often associated with specific clinicopathologic entities. However, the presence of an EWSR1 rearran...

Mass Cytometry Reveals Cell Type-specific Immune Remodeling in Placentas of Women with Chronic...

Hepatitis B virus (HBV) vertical transmission remains a major health challenge, and the characteristics of the placental immune microenvironment in chronic infection remain unclear. This study aimed...