Ben retweeted
the first 48 hours of Woke 2 has already produced more humor than the entire decade of Woke 1
Awesome
So get this...a stranger DM'd me on X and offered to help design my backup cancer drug. For free!
His name is Jan Domanski @jandom_random. He runs science at @open_fold, an open-source AI model that predicts how proteins and drugs physically fit together.
My cancer is driven by one broken protein called ALK. Lorlatinib (the daily pill I take) jams itself into it and shuts it down. It's working. But resistance isn't an if, it's a when. The tumor mutates the pocket and the drug stops fitting.
So Jan started modeling it on his own time, burning his own tokens. He ran AI models against ALK and lorlatinib, mapping where the known escape mutations land.
And what did he find? Most of them hit right in the drug's pocket, swapping small pieces for bigger ones that physically block the drug. That's the good kind of bad news. A pocket problem is something you can design around.
But the normal route to a new drug is ~2 years and ~$4-5M just to be ready for human testing. Jan's dream is getting a medicine to one patient in ~1 month.
I'm not taking a homemade molecule while lorlatinib works. But if it ever fails....shit...I've got a guy!
I started posting actively on X just a few weeks ago and it has brought me together with the most amazing, generous people!
uhhhh…guys??
We asked GPT-6 Astra to edit Qwen3.5-0.8B weights to improve math.
It directly changed only 0.016% of weights, fixing 0.8B's reasoning loops & improving math up to 6x and even instruction following 3x, without gradients or training.
We call this Weight-Space Programming: frontier LLMs can now natively read/write neural network weights! 🧵
Blog: rikiyat.github.io/blog/weigh…
Readers added context they thought people might want to know
LLM was given weights explicitly as text in prompt and used code/forward passes (per authors' logs) to ablate Qwen looping direction, a known thinking-mode issue per model card. Primarily fixed repetition in that mode, not general 'natively' improving weights/math.
rikiyat.github.io/blog/weight-sp…
github.com/RikiyaT/lm_und…
huggingface.co/Qwen/Qwen3.5-0…
huggingface.co/RikiyaT/Qwen3.…
Ben retweeted
We believe it’s underrated how relevant safety classifiers are when picking the best model for certain use cases. For example, Muse Wonder Full is actually the best available cyber model today by a meaningful margin. (5/7)
Ben retweeted
They’re all so close to getting it
I sold my Apple stock over this
Dear @Apple, I really wish “Delete and Report Spam” meant they wouldn’t text me again
Buffett and Abel definitely buying the dip.
Greg Abel on why he like $GOOGL $GOOG
“We have a lot of visibility from within our companies as to how we're using AI, what type of benefits it's delivering, so that brought incremental interest, and then we saw Google as a significant player.”
Nothing on competitve advantage, moat, valuation, ROIC, earning power.
Ben retweeted
It is completely insane to subject yourself to paying for health insurance when @crowdhealth exists.
I pay $725 per month for a family of five. We’ve been members since 2021, have had two babies, multiple health events, and couldn’t be happier.
We’re paying less than $10,000 a year and never have a problem. Free yourself from the extortion of health insurance and become a member.
Ben retweeted
The anti-ai grift is highly profitable today.
The media will have on anyone who hates AI.
Doesn’t matter what their credentials are, how inaccurate their previous predictions have been, or if there’s any resemblance of truth to anything they say.
If you hate AI and are willing to say it’s bad. You will get as much air time as you want.
Ben retweeted
Bullish $GOOGL signal
I'm getting more concerned about $GOOG because they need an answer to personalized bots.
Three key topics for earnings tonight:
1. Cloud growth outlook. Expect 92% growth in September and 95% in December. I think they guide to a slight step-up in growth in December.
2. Capex. Street at $201B in CY26 and $312B in CY27. I think that's the right number.
3. How do they win with personalized bots? Can Google have an AI Overview and AI Mode encore to direct search traffic into personalized bot usage?
Ben retweeted
Many of you don't understand how serious this is, so let me break it down.
In computer science there is a famous kind of puzzle called 3-SAT. You are given a long list of yes-or-no switches and a set of rules about how they must be arranged, and you have to find a combination that satisfies every rule. The obvious way to solve it is to try every combination, but each new switch doubles the number of possibilities, so a puzzle with a few hundred switches would take longer than the age of the universe to brute force.
For decades, the smartest people in the field found clever tricks that made this a little faster, but every trick still hit the same wall: the time required kept exploding as the puzzle grew.
About 25 years ago, two computer scientists, Russell Impagliazzo and Ramamohan Paturi, working with Francis Zane, turned that wall into a formal idea.
They proposed the Exponential Time Hypothesis, which says this explosion is not a failure of human cleverness but a law of nature. No algorithm, however brilliant, will ever solve 3-SAT without the time blowing up exponentially. Nobody could prove it, but almost everyone believed it, and it became one of the foundations of modern computer science.
Researchers used it as a measuring stick. If you could show that solving some other problem quickly would also crack 3-SAT quickly, you had shown that problem was hopelessly hard too. Hundreds of papers, across scheduling, graphs, logic and much more, rest on this one assumption.
Now an internal AI model at OpenAI claims to have broken it. It says it found an algorithm that solves these puzzles meaningfully faster than the hypothesis allows, and it has checked the proof in a computer verification system called Lean.
And here is the remarkable part: the very people who proposed the hypothesis, Impagliazzo and Paturi, along with MIT's Ryan Williams, are now leading the public review of whether a machine has disproved their own idea.
So what happens next? If the disproof holds, a large part of theoretical computer science has to be revisited.
Every result that said "this problem cannot be solved faster, assuming ETH" loses its foundation, and researchers will have to work out which of those walls were real and which were simply where we stopped looking. It does not mean everything becomes easy. The new algorithm is still slow in absolute terms and this is not the famous P versus NP problem being solved.
But it means our map of what is possible was wrong in a place we were very confident about, and it was an AI that redrew it. If the disproof fails, the hypothesis survives and the field breathes out, but we will still have watched an AI produce serious, checkable work on one of the deepest questions in the discipline, closely enough that the founders of the idea had to take it seriously. Either way, something has shifted.
Ben retweeted
I remember my first time waiting for the check in a European restaurant too
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