Alex Cryer (@Alex_Cryer) profile picture

Alex Cryer

@Alex_Cryer

Postdoctoral researcher @BrighamWomens @harvardmed and @MIT. Focused on immunomodulation using biomaterials.

 Boston, MA
Joined October 2012
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Photo by Alex Cryer (@Alex_Cryer)
First paper from my PhD out in @ACS_AMI. Great collaboration between @ImperialNHLI and @impchemistry! Happy to see this work finally published. Thankful for excellent students and academics who worked with me. pubs.acs.org/doi/full/10.102…
Tyrosine Kinase Inhibitor Gold Nanoconjugates for the Treatment of Non-Small Cell Lung Cancer

Tyrosine Kinase Inhibitor Gold Nanoconjugates for the Treatment of Non-Small Cell Lung Cancer

Abstract. Gold nanoparticles (AuNPs) have emerged as promising drug delivery candidates that can be leveraged for cancer therapy. Lung cancer (LC) is a het

pubs.acs.org
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Review with @drphilmol on the contribution of infection and the respiratory microbiome in acute exacerbations of idiopathic pulmonary fibrosis err.ersjournals.com/content/… – at London, England
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If you’re interested in nanotechnology and lung cancer, have a read for free.
Dr Andrew Thorley (@DrAJThorley) profile pictureDr Andrew Thorley@DrAJThorley23 May 2019
Free access to our new review article in Pharmacology & Therapeutics on #nanotechnology and #lung #cancer. authors.elsevier.com/a/1Z68x… @ELSpharma
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Review with @NanoTecResearch on the use of #nanotechnology in #lung #cancer diagnosis and treatment out now. doi.org/10.1016/j.pharmthera…
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So proud of @ErinMGibson, @LiddelowSA et al, who persisted through nearly 7 years of work on this study. "Chemobrain" affects millions of cancer survivors. Through a better understanding of the pathophysiology, new treatment strategies will emerge. #glia cell.com/cell/fulltext/S0092…
Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-...

Methotrexate Chemotherapy Induces Persistent Tri-glial Dysregulation that Underlies Chemotherapy-...

Microglial activation by methotrexate leads to a persistent disruption of oligodendrocyte lineage dynamics and astrocyte reactivity, resulting in the long-term cognitive impairment associated with...

cell.com
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The full peer-reviewed @sciencemagazine evaluation of #AlphaZero is here - a single algorithm that creatively masters chess, shogi and Go through self-play deepmind.com/blog/alphazero-…
Image from Google DeepMind (@GoogleDeepMind)
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Not all the T cells that are intratumoral are necessarily tumor reactive - that number is ~10%. Might explain why even empirically "hot" tumors have variable response to ICIs. This is also pertinent to ongoing efforts at isolating TILs from solid tumors. nature.com/articles/s41591-0…
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Great news! Life saving work.
Lungs for Living (@lungsforliving) profile pictureLungs for Living@lungsforliving4 Dec 2018
Great to announce the SUMMIT study on BBC radio this morning. We will CT screen 25000 people in London for lung cancer and a further 25000 will be invited to help us develop a multi-cancer detection blood test working with a US company GRAIL @Peston @wellcometrust @CRUKresearch
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Using AI to help scientists solve big questions is at the core of DeepMind’s mission. Today we’re delighted to announce our first significant milestone: a successful application of machine learning to the protein folding problem. deepmind.com/blog/alphafold/ #AlphaFold (1/5)
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In two different mouse models of #cancer, @Regeneron scientists found the dual treatment of PD-1 and GITR antibodies resulted in greater antitumor responses, compared to treatment with either antibody alone: bit.ly/2EZwCI4
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In this new Review, Pollard and Cassetta tell us about the different approaches to target and reprogramme pro-tumoural activities of tumour-associated macrophages go.nature.com/2CU3KhP
Image from Nature Reviews Drug Discovery (@NatRevDrugDisc)
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For this #NationalNanoDay why not read some of our recent nanoscience and nanotechnology books? The first chapter of our professional reference books can be read for free through your Royal Society of Chemistry account rsc.li/1LQ3FLv
Image from Royal Society of Chemistry (@RoySocChem)
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BREAKING NEWS: The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Chemistry 2018 with one half to Frances H. Arnold and the other half jointly to George P. Smith and Sir Gregory P. Winter.
Image from The Nobel Prize (@NobelPrize)
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As a group leader, I'm proud that: -I am not the most technically proficient person in my lab -I do not have all of the answers -The most creative ideas do not come from me Instead, I coach and mentor an amazing team of people who together drive our innovation and accomplishments
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BREAKING NEWS
The Royal Swedish Academy of Sciences has decided to award the #NobelPrize in Physics 2018 “for groundbreaking inventions in the field of laser physics” with one half to Arthur Ashkin and the other half jointly to Gérard Mourou and Donna Strickland.
Image from The Nobel Prize (@NobelPrize)
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BREAKING NEWS The 2018 #NobelPrize in Physiology or Medicine has been awarded jointly to James P. Allison and Tasuku Honjo “for their discovery of cancer therapy by inhibition of negative immune regulation.”
Image from The Nobel Prize (@NobelPrize)
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Publication bias and the importance of "negative" results @nytimes nytimes.com/2018/09/24/upsho…
Congratulations. Your Study Went Nowhere. (Published 2018)

Congratulations. Your Study Went Nowhere. (Published 2018)

Researchers should embrace negative results instead of accentuating the positive, which is one of several biases that can lead to bad science.

nytimes.com
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Neural networks and NSCLC, interesting @NatureMedicine article demonstrating diagnostic and predictive ability of AI. nature.com/articles/s41591-0…
Restoration of tumour-growth suppression in vivo via systemic nanoparticle-mediated delivery of PTEN mRNA nature.com/articles/s41551-0…
Image from Nature Biomedical Engineering (@natBME)
Image from Nature Biomedical Engineering (@natBME)
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Live-cell phenotypic-biomarker microfluidic assay for the risk stratification of cancer patients via machine learning rdcu.be/60RU
Image from Nature Biomedical Engineering (@natBME)
Image from Nature Biomedical Engineering (@natBME)
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