@ScienceMagazine

Cutting-edge research, news, commentary, and visuals from the Science family of journals. Follow @NewsfromScience for stories from our News team.

 Washington, DC & Cambridge, UK
science.org/
Joined April 2009
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Researchers have developed an AI-based approach to help physicians with real-life clinical workups, starting with the patient’s chief complaint, systematically asking questions and deciding what laboratory and imaging tests to order, and then continuing the evaluation on the basis of the answers received. Learn more this week in Science: scim.ag/3U8xn94
This image depicts a patient and a physician working together with artificial intelligence (AI) to reach a diagnosis.

ALT This image depicts a patient and a physician working together with artificial intelligence (AI) to reach a diagnosis.

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Eric Topol
@EricTopol19h
Imagine a system for people with diabetes that could continuously monitor glucose and keep its level steady and under control without drugs. Oh, here it is, at least one that works well in mice @ScienceMagazine science.org/doi/10.1126/scie…
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A new slate of #optogenetic tools enables scientists to finely control G protein signaling in excitable cells—providing a flexible method that might also be used therapeutically for disorders that disrupt the excitability of cells. @SciSignal scim.ag/4eImxxk
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Eric Topol
@EricTopol19h
Just in time for the World Series, the "robot-ump" science.org/content/article/… by @sciencecohen @ScienceMagazine

Inside the science of the ‘robo ump’ revolutionizing baseball

With high-speed cameras and a “pitch cannon,” researchers are refining the automated ball-strike system about to call its first World Series

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Eric Topol
@EricTopol22h
Just published @ScienceMagazine Higher medical accuracy at lower cost A 3-agent AI for sequential diagnosis nearly doubled accuracy compared with physicians for >300 @NEJM CPC cases and >300 ER cases AND substantially lowered cost, also exceeded performance of many AI models, physicians plus AI @HarshaNori @erichorvitz @Dominic1King @mustafasuleyman
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Science is publishing an Erratum to replace the June 2026 Editorial Expression of Concern for the September 2024 Research Article “Durably reducing conspiracy beliefs through dialogues with AI.” scim.ag/4dPOWRT
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Last chance: Apply for the BioInnovation Institute & #ScienceTranslationalMedicine Prize for Innovations in Women’s Health This prize recognizes researchers who have developed innovative advances with translational potential to impact women’s health globally. The Grand Prize winner will be awarded a cash prize of USD 25,000 and have their winning essay published online in Science Translational Medicine. Apply by 1 November 2026: bit.ly/4APCJGP
BII Science Translational Medicine advertisement for the Prize for Innovations in Women's Health. Background features a pink, abstract artistic design. Prominent text reads "Apply now..."

ALT BII Science Translational Medicine advertisement for the Prize for Innovations in Women's Health. Background features a pink, abstract artistic design. Prominent text reads "Apply now..."

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STAT3 is a cytokine-sensitive switch regulating NK cell differentiation in a mouse model of antiviral response. Learn more in @SciImmunology about the study’s possible implications for STAT3 immunotherapy and cancer progression: scim.ag/3WsoUhy
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Science Careers@ScienceCareers22h
2026's @ScienceMagazine Top Employers: From AI to I do AI is a bigger consideration for job seekers this year, but some things don't change: scientists want to work where science and people are prized. Discover this year’s rankings: bit.ly/3WHm5t5 #SCTopEmployers
Red background with text: "2026's Top Employers: From AI to I do." Includes a logo for "Science 2026 Top Employer." Below the text, a graphic shows a robotic hand reaching out to a human hand. A black button reads "See Full List."

ALT Red background with text: "2026's Top Employers: From AI to I do." Includes a logo for "Science 2026 Top Employer." Below the text, a graphic shows a robotic hand reaching out to a human hand. A black button reads "See Full List."

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An implantable, wirelessly powered electronic device could offer a drug-free approach to managing the intertwined metabolic disorders of obesity and type 2 diabetes. The device uses electrocatalysis to remove excess glucose from the bloodstream on demand. Learn more in Science: scim.ag/47twScK
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Home decorating isn’t unique to Homo sapiens. More than 40,000 years ago, bands of Neanderthals turned a spacious rock shelter in the mountains of Spain into a cozy home, fashioning wood into tools and windbreaks and burning it for heat and light. That picture comes from a first-of-its-kind trove of Neanderthal wooden artifacts from a domestic space, found at a cliffside site called Abric Romaní, 50 kilometers west of Barcelona. Learn more: scim.ag/3VK5zZb @NewsfromScience
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By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. Find out more in @ScienceTM: scim.ag/3UycT9T
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Animals and plants use conceptually similar immune systems to detect microbes and activate defenses. In both lineages, pattern recognition receptors (PRRs) perceive pathogen- or microbe-associated molecular patterns (PAMPs or MAMPs) and host-derived damage-associated molecular patterns (DAMPs). Whereas animals rely on specialized immune cells, plants harness individual cells expressing diverse PRRs. In the apoplast, which lies outside the plasma membrane and includes the cell wall, PRRs detect immunogenic fragments released from microbial proteins by plant hydrolytic enzymes. Conversely, pathogen-secreted enzymes can degrade constituents of the apoplast, generating DAMPs that activate immunity. In three new Science papers, researchers report expansions of this surveillance, revealing receptor architectures and mechanisms that enable plants to discriminate immunogenic carbohydrates. The findings illustrate how ligand specificity and receptor assembly confine immune activation to the context of microbial challenge. Learn more in a new #SciencePerspective: scim.ag/4ib9BRC
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Last call: Apply for the BioInnovation Institute & Science Prize for Innovation This prize recognizes bold researchers who are asking fundamental questions at the intersection of the life sciences and entrepreneurship. The Grand Prize winner will receive a cash prize of USD 25,000 and have their winning essay published in Science, in print and online. Apply by 1 November 2026: bit.ly/3TuI19S
The image features a logo with the words "BII Science Prize for Innovation" written in dark lettering.

ALT The image features a logo with the words "BII Science Prize for Innovation" written in dark lettering.

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In the latest #SciencePodcast🎙️, Contributing Correspondent Lizzie Wade dives into how archaeologists are revisiting the standard Inca chronology as radiocarbon dates mix up the timeline for the empire’s inception and growth. 🎧 Listen here: scim.ag/4jmkwKA
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Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @ScienceTM scim.ag/4jpH795
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How does the #glycome of gamma-delta T cells affect their activation toward an autoimmune state? Learn more in Science #Immunology about these important sugar molecules and their impact on inflammatory disease. scim.ag/47UlTJn
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Does generative AI dilute markets for human-created work? In a new #SciencePolicyForum, researchers discuss how market dilution theory, which could affect AI use in science, requires conceptual clarity and empirical evidence: scim.ag/4eDnln9
A black background displays a quote: "... this theory lacks a conceptually meaningful definition." Attributed to Samuelson et al. in white text.

ALT A black background displays a quote: "... this theory lacks a conceptually meaningful definition." Attributed to Samuelson et al. in white text.

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A new antifungal drug architecture combats infections in mice without the usual toxicity, a fluorescent imaging agent could enable more pinpointed removal of lung cancer tumors, and more in this week's new issue of #ScienceTranslationalMedicine. scim.ag/4z2AYEQ
Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine

ALT Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine

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Science Advances@ScienceAdvancesOct 21
Researchers have developed a single-cell–level digital twin to simulate how different treatments can alter maternal immune pathways and affect the time to labor of individual patients. Learn more this week in Science Advances: scim.ag/4k8o4Ap
Illustration of a digital twin modeling different potential outcomes to preterm birth treatments. Credit: Clara Leibenguth

ALT Illustration of a digital twin modeling different potential outcomes to preterm birth treatments. Credit: Clara Leibenguth

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