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BADRlab

@BadRlab

We study genetic drivers, cancer metabolism, and therapeutics for cancer stem cells/brain tumors/#glioblastoma @HarvardMed | @MGHNeurology | @MGH_RI 🇱🇧🇺🇸

 Boston, MA
massgeneral.link/BadrLab
Joined March 2019
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Very excited to share our latest work now out in @ScienceTM on targeting #lipidmetabolism in #glioblastoma Great team effort led by @katharinaeyme @ale__samma with other past/present lab members and our collaborators at @Yumanitytx and @UCLA 🧵👇 science.org/doi/10.1126/scit…
Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblast...

Targeting de novo lipid synthesis induces lipotoxicity and impairs DNA damage repair in glioblast...

A clinical-grade inhibitor of SCD delays tumor growth and increases sensitivity to DNA-damaging agents in GBM preclinical mouse models.

science.org
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Our new paper shows that targeting the enzyme SCD in breast cancer brain metastasis (BCBM) disrupts lipid metabolism and boosts anti-tumor immunity! This could pave the way for new therapies for this devastating disease. #BCBM #breastcancer nature.com/articles/s42003-0…
Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast...

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast...

Communications Biology - Pharmacological inhibition of SCD induces lipotoxicity, impairs DNA damage repair, enhances antigen presentation and interferon signaling, and reduces immunosuppressive...

nature.com
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Yet another fantastic collaboration with the Bensinger Lab @UCLA, led by @ale__samma! Grateful to everyone who contributed to this work and to our funding supporters who made it possible 🙌 #Collaboration #Research @MGHNeurology @harvardmed @MGH_RI
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Honored to host Christian Badr @BadRlab who visited us from Massachusetts General Hospital/Harvard Medical School @MGBResearchNews @MassGenBrigham @harvardmed for our Pharmacology Seminar Series @SBUPharm at Stony Brook University @SUNY @StonyBrookMed @SBUResearch @stonybrooku...
Image from Gilbert J. Rahme (He/him/his) (@GilbertRahme)
Image from Gilbert J. Rahme (He/him/his) (@GilbertRahme)
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That was #EANO2024 – Congrats to Alessandro Sammarco for winning Best Poster Presentation in Glasgow! 🎉Research: Targeting SCD triggers lipotoxicity & enhances anti-tumor immunity in breast cancer brain metastasis models (Poster P04.03.A) #NeuroOncology #CancerResearch #btsm
Image from EANO (@EANOassociation)
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It was an honor to present our work on targeting lipid metabolism in #BrainTumors at #SNO2024. Deeply grateful to my lab members for their incredible hard work and talent. ⁦@MGH_RI⁩ ⁦@MGHNeurology⁩ ⁦@MGHNeuroOnc⁩
Image from BADRlab (@BadRlab)
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👏Congratulations to our #EANO2024 award winners for Best Poster Presentation: Sophie Bockel (Clinical research), Alicia Buck (Basic research), Alessandro Sammarco (Translational research), Cressida Lorimer (Supportive care & quality of life research)! #NeuroOncology #btsm
Image from EANO (@EANOassociation)
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Off to Glasgow for #EANO2024. Excited to present some of our work on lipid metabolism in #braintumors. Also proud of @ale__samma , who was selected to present his work on breast cancer brain metastasis during the Poster Pitches Session @EANOassociation @MGH_RI @MGHNeurology
Image from BADRlab (@BadRlab)
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Exciting things are happening at the #ABTANationalConference! 🎉 Our amazing AARN members—leading brain tumor researchers—are here sharing groundbreaking ideas and innovations that bring us closer to finding a cure! 🙌💡🧠 #BrainTumorResearch #MeetHopeHeadOn #CureBrainTumors”
Image from American Brain Tumor Association (@theABTA)
Image from American Brain Tumor Association (@theABTA)
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Excited to share our latest work where we tested the effect of a brain-penetrant clinical-stage inhibitor of fatty acid desaturation on cancer and immune cells in breast cancer brain metastasis mouse models. @BadRlab @katharinaeyme biorxiv.org/content/10.1101/…
Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast...

Targeting SCD triggers lipotoxicity of cancer cells and enhances anti-tumor immunity in breast...

Breast cancer brain metastases (BCBM) are a significant cause of mortality and are incurable. Thus, identifying BCBM targets that reduce morbidity and mortality is critical. BCBM upregulate Stearoy...

biorxiv.org
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Are you ready for #BTAM? Let us do the work for YOU! Download the ABTA toolkit: bit.ly/ABTAMHHOToolkit 💜 #BTSM #braintumorawareness #braintumorresearch
Image from American Brain Tumor Association (@theABTA)
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We have an open post-doc position in our lab to explore novel approaches to target #braintumors . If you have strong expertise in cancer biology and a relevant publication record, feel free to reach out with your resume and cover letter @MGHNeurology @harvardmed @MGH_RI
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Reunion with my mentors… full circle back to Neuro-oncology @BadRlab @TannousLab @NeuroOnc #SNO2023 – at Vancouver, British Columbia
Image from Arsalan Hashemi Aghdam (@arsalanaghdam)
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Made it to @neuroonc #sno2023 meeting! Very much looking forward for the next 3 days ahead #btsm #curebraincancer
Image from BADRlab (@BadRlab)
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For 50 years @theABTA has been supporting #braincancer patients, caregivers, and researchers. They had a tremendous impact on my career as a researcher. Please consider supporting their mission. Learn more at: MeetHopeHeadOn.org #MeetHopeHeadOn #BTSM #BrainTumorAwareness

Meet Hope Head On - American Brain Tumor Association

We’re $18 MillionCloser to Hope You’re here because you hope for a future without brain tumors. So do we.  Meet Hope Head On is our $50 million campaign to triple […]

abta.org
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My promotion to Associate Professor of #Neurology at #Harvard Medical School @MGHNeurology @MGH_RI @MGHNeuroOnc is now official. I owe this to the superb mentors and wonderful scientists I had the privilege to work with over the years.
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A big thank you to my family for their support, to those who funded our research, to #braintumors #GBM patients who give us the drive and motivation every day, and to the referees who generously accepted to write my letters.
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We are looking for a Postdoctoral Fellow to join our group at the University of Florida (deleyrollelab.carrd.co/). If you are interested in brain tumor, immunology, and immunotherapy feel free to contact me!
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It is so exciting to see our work highlighted in @NatRevDrugDisc Drugging a metabolic vulnerability in glioblastoma nature.com/articles/d41573-0…
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In a recent @ScienceTM study, researchers from @Badrlab @MGHNeurology @MGHNeuroOnc found that an investigational drug may combat brain tumors by targeting cancer cells' fat production. Read more: massgeneral.org/news/press-r… #cancer #braintumor
Image from Mass General Brigham Research (@MGBResearchNews)
Image from Mass General Brigham Research (@MGBResearchNews)
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massgeneral.org/news/press-r… @MGHNeurology @harvardmed @MGH_RI #glioblastoma #MedTwitter #AcademicTwitter #BTSM
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