@ScienceTM

Science Translational Medicine is the leading weekly online journal publishing translational research at the intersection of science, engineering and medicine.

 Washington, DC
science.org/journal/stm
Joined February 2011
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2.7KMedia
🎉 Congratulations to Moran Amit, winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award! Sign up now for his lecture about his prize-winning work on how cancers reprogram nerves, which is 9 October at the @AAAS building and via livestream: scim.ag/4701AKi
Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

ALT Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

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By applying a unique polyene scaffold, researchers engineer a next-generation, broad-spectrum #antifungal that selectively targets ergosterol without binding to cholesterol, avoiding severe toxicity linked to drugs like amphotericin B. scim.ag/4yyYZSP
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A new antifungal drug architecture combats infections in mice without the usual toxicity, a fluorescent imaging agent could enable more pinpointed removal of lung cancer tumors, and more in this week's new issue of #ScienceTranslationalMedicine. scim.ag/4z2AYEQ
Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine

ALT Successful hematopoietic cell transplantation (HCT) requires immunosuppression to prevent graft-versus-host disease (GVHD), but the choice of regimen may shape immune reconstitution and GVHD risk. DeWolf et al. analyzed the T cell repertoires of clinical trial participants who received either tacrolimus and methotrexate (Tac/MTX) or posttransplant cyclophosphamide, mycophenolate mofetil, and tacrolimus (PT-Cy) as GVHD prophylaxis after HCT. PT-Cy more profoundly depleted the T cell compartment, creating a bottleneck as depicted on the cover, which resulted in a less diverse T cell repertoire. This reduced diversity was associated with lower GVHD risk but higher risk of infection after transplant. These findings show that immunosuppressive regimens can shape the balance between beneficial and harmful outcomes of HCT. Credit: N. Burgess/Science Translational Medicine

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AI is transforming the discovery and design of #antibiotics but requires concurrent progress in data standards, validation pipelines, and regulation to reach patients, argues a new Viewpoint. @delafuentelab @Hanqun_CAO @MIT_IMES scim.ag/4z09IH9
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In a new Editorial, researchers sound the alarm against the rising tide of rifampicin-resistant #tuberculosis and urge the need for an effective vaccine and control measures that integrate genomics and social interventions. @Unesp_Oficial @facfarmaciaUL scim.ag/47YQ7Lo
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A new Viewpoint discusses how integrating modernized commercial models, genomic surveillance, streamlined trial design, advances in #AI, and other innovations can tackle the dangers of #AntibioticResistance. @GSK scim.ag/4zEtNm7
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A small molecule therapy for #Alzheimers disease that activates #TREM2 in #microglia boosts the breakdown of amyloid-beta in neurons and mice and is well-tolerated in healthy individuals and patients, according to results from a phase 1 trial. @sanofi scim.ag/4jYmDEv
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A new Editorial stresses the importance of the simple but fundamental concept of prevention in combating antimicrobial resistance, and calls for more support for IPC and WASH in low- and middle-income countries to reduce antibiotic demand. @EdinUniUsher scim.ag/3Uv4kfY
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With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite's lifespan. scim.ag/4yvGu2q
Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.

ALT Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.

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Applying Fc engineering, researchers fashion potent bispecific antibodies against #SARSCoV2 that can be delivered via mRNA to target multiple viral epitopes and can constrain the virus’ ability to evade recognition. @moderna_tx scim.ag/47Vt445
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By parsing metabolic data from more than 18,000 participants in China, scientists have derived new “clock” models of metabolic #aging that incorporate novel metrics linked to higher chronic disease risk and all-cause mortality. @sjtu1896 scim.ag/4zzZLzU
A person rides a bicycle on a flat surface. The shadow cast on an orange background shows the person on a larger bicycle with clock faces as wheels.

ALT A person rides a bicycle on a flat surface. The shadow cast on an orange background shows the person on a larger bicycle with clock faces as wheels.

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The new issue of #ScienceTranslationalMedicine is out! A large clinical study in China uncovers "clocks" of human aging that may predict chronic disease, a new mRNA antibody therapy could better tackle ever-evolving SARS-CoV-2 variants, and more. scim.ag/4yjVa3G
The cover illustration shows a man on a bicycle going about his daily activities as the shadow of time looms in the distance. Credit: Davide Bonazzi/Salzman Art

ALT The cover illustration shows a man on a bicycle going about his daily activities as the shadow of time looms in the distance. Credit: Davide Bonazzi/Salzman Art

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Moran Amit is the 2026 recipient of the #AAAS Martin and Rose Wachtel Cancer Research Award for his research on how cancer reprograms peripheral nerves to evade immunity—and how to target this relationship to support #immunotherapy. @UTMDAnderson scim.ag/4yGqnPL
Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

ALT Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

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Gut bacteria such as Lactobacillus prime intestinal epithelial cells in newborn mice to produce the antimicrobial protein calprotectin, making them less susceptible to sepsis and infection-related death. @CincyChildrens scim.ag/3WexRLg
An image showing two side-by-side microscopic views labeled "CNV" and "ABX." Both views feature colorful structures with red and blue hues, and the "ABX" view includes additional green areas at the top. They appear to depict biological tissue samples. Scale bars are present at the bottom of each view.

ALT An image showing two side-by-side microscopic views labeled "CNV" and "ABX." Both views feature colorful structures with red and blue hues, and the "ABX" view includes additional green areas at the top. They appear to depict biological tissue samples. Scale bars are present at the bottom of each view.

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A topical combo of the mite-killing compound #flavesone and the ovicidal drug #abametapir quickly wipes out mites and eggs that cause #scabies with a single dose and cures infections more quickly than ivermectin in pigs. @QIMRB_Institute @DeepsDarshi scim.ag/4z4XLPJ
A highly magnified view of a green dust mite covered in small particles, with a textured, spiky surface. The background has a rough, earthy appearance.

ALT A highly magnified view of a green dust mite covered in small particles, with a textured, spiky surface. The background has a rough, earthy appearance.

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An invasion of immune cells from skull bone marrow triggers inflammation that drives cognitive and mood decline with age in adults with chronic #TBI, shows work that also identifies #fenofibrate as a promising therapy in a pilot trial. scim.ag/3Tthp9c
This is a medical scan image showing a horizontal cross-section of a human brain. The areas within the brain exhibit varying shades of red and yellow, indicating different levels of activity or density. The background is black, highlighting the brain scan.

ALT This is a medical scan image showing a horizontal cross-section of a human brain. The areas within the brain exhibit varying shades of red and yellow, indicating different levels of activity or density. The background is black, highlighting the brain scan.

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An artificial lymph node provides a protected haven for tolerogenic dendritic cell therapy for autoimmune encephalitis in mice, with possible implications for #MultipleSclerosis therapy. scim.ag/4yDX28t
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Don't miss this afternoon's prize-winning lecture from Moran Amit, winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award. Sign up now to attend his talk in person at the @AAAS building or via livestream: scim.ag/4701AKi
Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

ALT Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

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🎉 Congratulations to Moran Amit, winner of the 2026 AAAS Martin and Rose Wachtel Cancer Research Award! Sign up now for his lecture about his prize-winning work on how cancers reprogram nerves, which is 9 October at the @AAAS building and via livestream: scim.ag/4701AKi
Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

ALT Extreme close-up of a colored false-color electron microscope image showing a human bone stem cell. The cell appears purple and yellow, with a textured surface against a bluish, abstract background.

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With tests in mice, researchers identify a new drug candidate delivered as a single, low dose to treat #schistosomiasis infection across the parasite’s lifespan. scim.ag/4yvGu2q
Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.

ALT Four panels show microscopic images of parasites. The top row depicts individual parasites labeled DMSO, MCLZ, M4339, and PZQ, all in different postures. The bottom row displays corresponding close-up textures of each parasite's surface.

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