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Benjamin Grodner

@BenjaminGrodner

BME PhD Student in De Vlaminck Lab at Cornell University

 Ithaca, NY
Joined November 2018
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Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)Photo by Benjamin Grodner (@BenjaminGrodner)
Our paper! 🪩 "Spatial mapping of mobile genetic elements and their bacterial hosts in complex microbiomes" Full text link: doi.org/10.1038/s41564-024-0…
Image from Benjamin Grodner (@BenjaminGrodner)
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This method can help advance the study of microbial ecology, serving as a complement to metagenomic sequencing by revealing the spatial interplay between bacteria, plasmids, and phage.
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Check out the manuscript for all the lovely details and discussion! doi.org/10.1038/s41564-024-0…
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📢 Short talks: Dr Ben Grodner @Cornell ✅HiPR-FISH (PMID: 33268897) maps genera spatial heterogeneity (#biofilms) ✅MGE-FISH mapping mobile genes ✅overlap tools to determine interactions and spatial ecology doi.org/10.1101/2023.06.09.5… #HavingIMPACTT2023 @IMPACTT_Canada
Image from Dr. Heather Armstrong (@DrHArmstrong)
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Benjamin Grodner retweeted
Joe J. Harrison (@JoeJHarrison1) profile picture
Joe J. Harrison@JoeJHarrison112 Jul 2023
Elegant technique from @BenjaminGrodner using molecular barcoding to visualize mobile DNA transfer - many applications to microbiome studies, bacterial genetics, and basic biofilm microbiology. Also - beautiful images. #HavingIMPACTT2023 @IMPACTT_Canada biorxiv.org/content/10.1101/…
Image from Joe J. Harrison (@JoeJHarrison1)
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I’m very pleased to share our new preprint where we simultaneously map MGEs and bacterial taxa in complex microbiomes, revealing their spatial structures.
Iwijn De Vlaminck (@IwijnDeVlaminck) profile pictureIwijn De Vlaminck@IwijnDeVlaminck10 Jun 2023
Spatial Mapping of Mobile Genetic Elements and their Cognate Hosts in Complex Microbiomes biorxiv.org/content/10.1101/…
Spatial Mapping of Mobile Genetic Elements and their Cognate Hosts in Complex Microbiomes

Spatial Mapping of Mobile Genetic Elements and their Cognate Hosts in Complex Microbiomes

The frequent exchange of mobile genetic elements (MGEs) between bacteria accelerates the spread of functional traits, including antimicrobial resistance, within the human microbiome. Yet, progress in...

biorxiv.org
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We suggest that MGE mapping can serve as a direct complement for metagenomic sequencing of spatially structured microbiomes. We envision two potential application areas.
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First, the methods could be employed to investigate the processes that govern the emergence of antibiotic resistance. Second, MGE mapping can help address the challenge of determining bacteriophage host taxa, which is crucial in phage therapy.
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