
š®š³ | Assistant Professor @UNMC_GCBA | #NewPI | Chromatin genomics and biochemistry | Henikoff lab @fredhutch and @BlaineBartholo2 lab alumnus
- Tweets962
- Following522
- Followers721
- Likes1.7K

ALT Timeline of the discovery of key subunits of chromatin remodelers. SWI/SNF: switch/sucrose nonfermentable. ISWI: Imitation Switch. CHD: chromodomain-helicase DNA-binding. INO: Inositol-requiring mutant 80. The names of the subunits are mostly limited to mammals; several common alternative names from other model organisms were included.

ALT Aberrant chromatin remodeling in cancer. Chromatin remodeling plays a critical role in DNA repair. First-level chromatin remodelers are recruited to double-strand break (DSB) sites, sustain DSB signaling, and can shift repair from homologous recombination (HR) to nonhomologous end joining (NHEJ), thereby facilitating DNA repair. Higher-order chromatin remodeling promotes DNA repair by segregating damaged chromatin. Aberrant chromatin remodeling leads to inefficient DNA repair and increases tumor cell sensitivity to DNA damage. Therefore, in tumors harboring inactivating mutations in chromatin remodelers, combination therapy with PARP inhibitors can achieve synthetic lethality.


























