Postdoctoral Fellow @Genentech / PhD & Postdoc @AlessioCiulli @UoDCeTPD 🏴🇬🇧/ MChem @univofstandrews / from Strasbourg 🇫🇷
St Andrews, Scotland
Joined July 2019
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Charlotte Crowe retweeted
Induced ubiquitination of the partially disordered estrogen receptor alpha via a 14-3-3 directed molecular glue-PROTAC @alessiociulli @CharlCrowe 👏nature.com/articles/s41467-0…
Charlotte Crowe retweeted
An excellent and timely review: Crowe & Ciulli (2026) Methods to Study the Molecular Mechanism and Drive the Design of Protein Degraders. Chem Rev ASAP #TPD #ChemBiol #MedChem #OpenAccess
doi.org/10.1021/acs.chemrev.…
Charlotte Crowe retweeted
TPD開発の際に考慮すべきことやアッセイ系の原理と利用場面などに関してまとめた総説がChemical Reviewsに公開されています。OAです。
余談ですが、First authorのCharlotte(@CharlCrowe)は、Dundeeではドラフトが隣でした。
pubs.acs.org/doi/10.1021/acs…
Charlotte Crowe retweeted
The Feb-March Journal Club edition is finally here!! Thanks to our amazing editors: @justgiorgia, Angus, Gajanan and Stefan. Read to catch up with the latest literature in TPD!
#openaccess #TPD #journalclub @UoDLifeSciences
sites.dundee.ac.uk/alessio-c…
ALT Front page for February to March 2025 Journal club showing a scientist at their fume hood
Charlotte Crowe retweeted
🥈 We are proud to announce that our laboratories in the Centre have achieved the Silver level LEAF (Laboratory Efficiency Assessment Framework) award!
LEAF is a standard set by UCL to improve the sustainability and efficiency of laboratories.
Next we aim for Gold!
ALT Text: Fantastic! CeTPD awarded silver level LEAF. How sustainable can YOUR division be?
Charlotte Crowe retweeted
📢 We’re thrilled to share the CeTPD Journal Club Special Edition! Get the details on each speaker’s work, their unique contributions to #TPD, and key takeaways from #CeTPDSymposium2024.
buff.ly/4g4pzuc
#openaccess #TPD #journalclub @UoDLifeSciences (1/41)
ALT Cover for "Protein degradation in focus" Special edition journal club for the symposium special edition
Charlotte Crowe retweeted
Congratulations 🎆(Dr.) @CharlCrowe for a successful PhD viva "Mechanisms and design of small molecule degraders recruiting the Cullin RING 2 VHL E3 ubiquitin ligase." @UoDLifeSciences @UoDCeTPD on 1 November 2024. Co-supervised by @alessiociulli & Ron T. Hay, support form @Tocris, internal @YKulathu & external @LabThoma. It was great seeing you transform from a chemist to #ubiquitin biochemist and structural biologist in #cryoEM ❄️🔬 in #TPD, co-founding @iSCEM_DD, and much more.
Charlotte Crowe retweeted
Mechanism of degrader-targeted protein ubiquitinability
Cool structural story
science.org/doi/10.1126/scia…
Charlotte Crowe retweeted
Targeting 'undruggable' diseases: Researchers reveal new levels of detail in targeted protein degradation @statuses @ScienceAdvances phys.org/news/2024-10-undrug…
Charlotte Crowe retweeted
We are one of the world leaders in targeted protein degradation research, revolutionising drug discovery by making treatment of diseases previously thought to be undruggable a reality.
Read more about the work, published in @ScienceAdvances, on our site: buff.ly/4eFduvl
Charlotte Crowe retweeted
Researchers have revealed new levels of detail in the workings of 'protein degraders', molecules which can be used to develop drugs for diseases such as cancer.
Magnified 3D imagery has shown, for the first time, how the technique works – @CharlCrowe, @UoDCeTPD, explains 👇
Charlotte Crowe retweeted
Thrilled to share that, together with my colleagues @UoDCeTPD and collaborators @Boehringer, we report @ScienceMagazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/scie…
Charlotte Crowe retweeted
Registration is now open for the 2nd Scottish Cryo-EM Symposium. After the inaugural meeting @dundeeuni, this year it is at the @UofGARC @UofGlasgow on 11th Nov. Registration is once again free, supported by our sponsors. The registration link is: eventbrite.com/e/the-scottis…
Charlotte Crowe retweeted
Finally, thanks to @Mark_A_Nakasone and @CharlCrowe for getting this symposium series started last year (and iSCEM-DD before that), and we look forward to seeing you all in Glasgow this year.
Photo: Kevin Haubrich.
ALT aerial photo of symposium attendees in an indoor, open atrium space
Charlotte Crowe retweeted
🧬 Only 6 days left to register for the @wellcometrust @The_MRC Single Particle Cryo-EM Course for Beginners!
📅 Join us Sept 23-27 at the @AstburyCentre to gain theoretical knowledge & hands-on experience in #cryoEM!
🧪Apply by July 31 2024
astbury.leeds.ac.uk/faciliti…
Charlotte Crowe retweeted
More congratulations are in order for our Short Talk winners, @CharlCrowe & @Alexis_Betr! Competition was tough with fantastic research shared throughout, well done both 👏🏼🥳
A huge thank you to to our judging panel for their efforts🙏🏻 #Ubiq24
Charlotte Crowe retweeted
✨What a group!✨Some fantastic research shared so far and there’s still much more to come. We’re looking forward to some down time in the Portuguese sunshine to rest and reset for this afternoons session #Ubiq24
Charlotte Crowe retweeted
We have been blown away by all the wonderful messages that we have received in response to our symposium! Thank you! It means a lot to all of us that our delegates had a fantastic time in Dundee and have left inspired to push forward the frontiers of TPD research!
#TPDFocus
ALT Group of people sat in a full lecture theatre
Charlotte Crowe retweeted
Didn't imagine I would be here when I was a master student attending my very first TPD symposium in Shanghai 5 years ago, feel honoured to be CeTPDers!
Thanks to the organisers
@alessiociulli
@CharlCrowe
@val_spiteri
etc. for making this happen!
We have been blown away by all the wonderful messages that we have received in response to our symposium! Thank you! It means a lot to all of us that our delegates had a fantastic time in Dundee and have left inspired to push forward the frontiers of TPD research!
#TPDFocus
ALT Group of people sat in a full lecture theatre
Charlotte Crowe retweeted
It was great to be able to showcase the city and the university to such a global audience. Thanks to the organisers @alessiociulli @CharlCrowe @val_spiteri etc. for putting on such a fantastic event (and somehow preordering the weather!) 👏
