@CrisprEh

Postdoc in the @marsonlab @GladstoneInst/@UCSF. Parker Scholar @parkerici. Interested in genomics, CRISPR, cancer immunotherapy, and much more! 🇨🇦

 San Francisco, CA
Joined May 2021
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Thrilled to have our recent work from the @marsonlab published in @ScienceMagazine science.org/doi/10.1126/scie…. This was the result of an awesome collaboration between myself and fellow Marson Lab postdoc, @R_Schmidt_ (1/12)

CRISPR activation and interference screens decode stimulation responses in primary human T cells

Complementary gain- and loss-of-function CRISPR-based genetic screens reveal tunable regulators of human T cell activity.

science.org
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Zach Steinhart retweeted
Maya Arce@maya_m_arce3 Sep 2025
Excited to share that the Arce Lab is launching today at @arcinstitute ! We will explore the mechanisms controlling immune cell function using genomics and biochemistry in an effort to understand immune-mediated diseases. arcinstitute.org/labs/arcela…

Arce Lab - Arc Institute

Arc Institute is an independent nonprofit research organization headquartered in Palo Alto, California.

arcinstitute.org
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Maya Arce@maya_m_arce11 Dec 2024
Excited to share the latest from the @MarsonLab! An investigation of context-specific gene regulation in T cells, which led to dynamic mechanisms required to control T cell rest and activation. Published today in @Nature thanks to the work of many! nature.com/articles/s41586-0…

Central control of dynamic gene circuits governs T cell rest and activation

Nature - Resting and activated T cell states are established by context-specific regulators and dynamic gene circuits.

nature.com
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ralf schmidt@R_Schmidt_13 Dec 2023
Excited to share a milestone in our forward genetics developments! Today in @Nature we report massive mutagenesis screening in T cells with base editors, increasing resolution from genes to nucleotides nature.com/articles/s41586-0… A @MarsonLab story with my dear friend @carlcward 1/10
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I am very excited to share our paper on the interactions between #gdTcells and cancer cells, out today in @Nature! Using #CRISPR screens, we uncovered unexpected pathways in cancer cells regulating target molecules recognized by γδ T cells. @MarsonLab 1/2 nature.com/articles/s41586-0…
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Majzner_Lab
@Majzner_Lab9 Mar 2023
Happy to share the newest paper from our lab. Led by technician extraordinaire Aidan Tousley (soon to be an MD/PHD student!), this manuscript details our attempts to reimagine the structure of CARs to improve their specificity and efficacy. rdcu.be/c7avS
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Zach Steinhart retweeted
Justin Eyquem@j_eyquem13 Jan 2023
Thrilled to share the first Eyquem lab paper! Today we report in @CellCellPress evolving the AAV6 capsid to enable efficient engineering of murine T cells. An exciting collab with @asokanduke and led by the brilliants @WilliamNyberg and Jon Ark cell.com/cell/fulltext/S0092… 🧵1/11

An evolved AAV variant enables efficient genetic engineering of murine T cells

By combining structure-guided evolution and genome-wide screening, this work identifies an adeno-associated virus and co-factor that enable gene targeting at high efficiencies in mouse T lymphocytes,...

cell.com
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I’m hiring a computational biologist at Genentech to analyze cutting-edge single-cell genomics and high-throughput screening data in an extremely collaborative environment focused on finding cures for disease. Please reach out to learn more. careers.gene.com/us/en/job/G…
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I'm very excited to share our review article rdcu.be/cHLHy @NatRevImmunol where we discussed how IL-2 has been engineered since its discovery to improve its in vivo activity and T cell selectivity and drive therapeutic efficacy in the context of autoimmunity and cancer.
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Thank you to the anonymous reviewers, @ScienceMagazine, and @ImmunoEditor for taking the time to provide important and constructive feedback.
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Lastly, on a personal note, special thanks to my wonderful and supportive wife @monika_mis 🤗
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