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CRISPR Platform

@CrisprPlatform

Genetic engineering is offering many new and exciting possibilities. Keep up-to-date with the latest developments and innovations.

 Amsterdam, Nederland
linkedin.com/in/danielwarmerdam
Joined January 2020
  • Tweets269
  • Following191
  • Followers146
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Photo by CRISPR Platform (@CrisprPlatform)
Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases HELIX: a newly engineered #CRISPR-associated transposases (CASTs) with high integration product purity and genome-wide specificity. nature.com/articles/s41587-0…
Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases

Precise cut-and-paste DNA insertion using engineered type V-K CRISPR-associated transposases

Nature Biotechnology - Engineered CRISPR-associated transposases improve the purity and specificity of DNA insertions.

nature.com
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🚨Preprint alert from #CRISPRBerlin🚨: Combining different CRISPR-nucleases for simultaneous non-viral knock-in and base editing prevents translocations in multiplex-edited CAR T cells. tinyurl.com/5by84ybh Not just one but many CRISPRs are amazing. A short thread 👇🧵 1/8
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Great overview of gene editing and gene therapy approaches marching toward the clinic. Also some great insights about viral vs. non-viral delivery: nature.com/articles/s41587-0…
For hemophilia and thalassemia, a new era of ‘one-and-done’ gene therapies has arrived

For hemophilia and thalassemia, a new era of ‘one-and-done’ gene therapies has arrived

Nature Biotechnology - Industry celebrates two newly approved genetic medicines, but patients with these blood disorders may face a long wait, and many will never access them because of their high...

nature.com
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CRISPR Platform retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol10 Nov 2022
Just published @Nature 1st #CRISPR genome editing of immune T-cells to treat cancer, individualized for 16 patients with solid tumors, with some success nature.com/articles/s41586-0… nature.com/articles/d41586-0… by @heidiledford
Image from Eric Topol (@EricTopol)
Image from Eric Topol (@EricTopol)
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RADARS is a new RNA-sensing system developed by @omarabudayyeh, @jgooten + Fei Chen @broadinstitute that allows scientists to detect and target specific cell types and states, opening up potential applications in diagnostics and therapeutics. 🧬 mcgovern.mit.edu/2022/10/27/…
RNA-sensing system controls protein expression in cells based on specific cell states - MIT...

RNA-sensing system controls protein expression in cells based on specific cell states - MIT...

Researchers at the Broad Institute of MIT and Harvard and the McGovern Institute for Brain Research at MIT have developed a system that can detect a particular RNA sequence in live cells and produce...

mcgovern.mit.edu
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The end of PCR machines? Engineered helicase replaces thermocycler in DNA amplification while retaining desired PCR characteristics doi.org/10.1038/s41467-022-3…
Image from Olivier Borkowski (@O_Borkowski)
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CRISPR Platform retweeted
Josh Tycko (@JoshTycko) profile picture
Josh Tycko@JoshTycko10 Oct 2022
Our paper is out! New recombinases for large DNA integration in human cells nature.com/articles/s41587-0… We discovered thousands of recombinases and their DNA targets by searching in mobile genetic elements🧬🦠 Our experiments showed some are promising tools for genome engineering🖋️
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CRISPR Platform retweeted
Luca Pinello (@lucapinello) profile picture
Luca Pinello@lucapinello4 Oct 2022
Do you want to learn where the gene editing field is heading? Please join us for this online event! Outstanding speakers lineup, *FREE* registration and several AWARDS for abstract submission: deadline *October 8th* Please retweet! #CRISPR hsph.harvard.edu/pqg-confere…
Image from Luca Pinello (@lucapinello)
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Engineered CRISPR prime editors with compact, untethered reverse transcriptases go.nature.com/3SCy1Fw
Image from Nature Biotechnology (@NatureBiotech)
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CRISPR Platform retweeted
BioCentury (@BioCentury) profile picture
BioCentury@BioCentury21 Sep 2022
Orbital: an RNA toolbox for vaccines and protein replacement with technology from @Stanford and @BeamTx, and backed by Arch. An Emerging Company Profile by BioCentury's Richard Guy @NTAPGuy buff.ly/3DHgese
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Combinations of single-stranded DNA repair templates and small molecules markedly enhance genome editing go.nature.com/3dS9NYC

High-yield genome engineering in primary cells using a hybrid ssDNA repair template and small-mol...

Nature Biotechnology - Combinations of single-stranded DNA repair templates and small molecules markedly enhance genome editing.

nature.com
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A growing pipeline of mRNA therapeutics is entering clinical trials, in particular systemic delivery of protein replacement therapy for rare monogenic disorders, and cytokines or antibodies for cancer immunotherapy - find out more in our latest news story go.nature.com/3Uq3VXu
Image from Nature Reviews Drug Discovery (@NatRevDrugDisc)
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CRISPR Platform retweeted
Stan Brouns (@StanBrouns) profile picture
Stan Brouns@StanBrouns18 Sep 2022
We just published a review on bacteriophage genome engineering methods, including various CRISPR approaches. Great work by PhD student Marina Mahler now in @PeterFineran’s group. Thanks @AnaRitaMCosta, Sam and Peter for contributing. cell.com/trends/biotechnolog…
Image from Stan Brouns (@StanBrouns)
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CRISPR Platform retweeted
David R. Liu (@davidrliu) profile picture
David R. Liu
@davidrliu8 Sep 2022
Today we report in @NatureBiotech the high-throughout phase-assisted continuous evolution of compact Cas9 variants that require only single-nucleotide pyrimidine PAM sequences (N4TN and N4CN). This work was a terrific collaboration with @MoKhalilLab. 1/8) drive.google.com/file/d/1qmF…
Image from David R. Liu (@davidrliu)
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CRISPR Platform retweeted
Synthego (@Synthego) profile picture
Synthego@Synthego1 Sep 2022
crispr
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CRISPR Platform retweeted
Connor Tou (@connorjtou) profile picture
Connor Tou
@connorjtou1 Sep 2022
Today in @BiochemistryACS, we share a perspective on emergent kilobase-scale genome editing technologies - including dual-flap prime editing, recombinases, and transposases (+ their variations). pubs.acs.org/doi/10.1021/acs…
Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies

Recent Advances in Double-Strand Break-Free Kilobase-Scale Genome Editing Technologies

Abstract. Genome editing approaches have transformed the ability to make user-defined changes to genomes in both ex vivo and in vivo contexts. Despite the

pubs.acs.org
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Reprogramming of antibody responses in mice is achieved via adeno-associated virus delivery of SaCas9, single guide RNA (sgRNA) and a repair template targeting immunoglobulin genes #NBTNV go.nature.com/3aMEbSw
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CRISPR Platform retweeted
AstraZeneca (@AstraZeneca) profile picture
AstraZeneca
@AstraZeneca26 Aug 2022
Immunocompromised patients continue to face ongoing risks from COVID-19. In this @politico article, sponsored by AstraZeneca, Iskra Reic, EVP, Vaccines and Immune Therapies talks about policy action to protect this community: know.az/3CzEKey
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CRISPR Platform retweeted
Eric Topol (@EricTopol) profile picture
Eric Topol
@EricTopol25 Aug 2022
Gene therapies, the potentially curative "miracles of medicine," are hitting stride with 40-50 expected to be approved by 2030. But their up front costs remains a formidable challenge, despite favorable cost-benefit analyses economist.com/briefing/2022/…
Image from Eric Topol (@EricTopol)
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An assay leveraging strand-displacement reactions and enzymatic amplification for the recognition of viral RNA and implemented on origami paper allows for the fast colorimetric detection of SARS-CoV-2 variants, with single-nucleotide specificity. nature.com/articles/s41551-0…
Image from Nature Biomedical Engineering (@natBME)
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