Research Scientist, EMBL Heidelberg, @podlesny.bsky.social
Joined August 2009
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Excited to release metaTraits.embl.de! 🦠 Explore 140+ 𝗺𝗶𝗰𝗿𝗼𝗯𝗶𝗮𝗹 𝗽𝗵𝗲𝗻𝗼𝘁𝘆𝗽𝗶𝗰 𝘁𝗿𝗮𝗶𝘁𝘀, harmonized & integrated from culture-derived collections 🔬 & genome-based predictions 🧬 for >2M MAGs & genomes.
Paper at NAR: doi.org/10.1093/nar/gkaf1241 🧵 1/9
Daniel Podlesny retweeted
For somebody working on the gut #microbiome, the responses ("gross", "embarrassment", "pseudoscience", etc.) to this @Nature article on the treatment of C-section babies with their mother’s poo are quite sobering. So, I thought I would provide a perspective in the thread below.
Feeding a baby born by caesarean section milk containing a tiny bit of their mother’s poo introduces beneficial microbes to their gut go.nature.com/48oD7hK
Daniel Podlesny retweeted
After a high dose of psilocybin, the brain desynchronizes at a massive scale, causing loss of our sense of self, time, and space. This may drive the burst of plasticity caused by psychedelics. The next day, brain activity has largely returned to normal, but an echo remains – a reset of circuits critical to the sense of self.
Our study is out today in @Nature nature.com/articles/s41586-0…
Daniel Podlesny retweeted
Thrilled to share our new preprint. A thread 🧵
biorxiv.org/content/10.1101/…
Daniel Podlesny retweeted
Immensely proud to share our four papers on #SingleCell dissection of #Alzheimers Disease coming out in @CellCellPress today, reporting 2.3M #scRNA profiles and 850k #scATAC profiles across 427 post-mortem human brain samples from AD and non-AD donors in a wonderful #interdisciplinary collaboration with @DrLiHueiTsai between @MIT @MIT_Picower @MIT_CSAIL @BroadInstitute @RushUniversity
Paper 1: scRNA + vulnerability + resilience cell.com/cell/fulltext/S0092…
Paper 2: scATAC + GWAS + Epigenome Erosion cell.com/cell/fulltext/S0092…
Paper 3: Microglia States + reprogramming cell.com/cell/fulltext/S0092…
Paper 4: DNA damage + gene fusions cell.com/cell/fulltext/S0092…
MIT News: news.mit.edu/2023/decoding-c…
Issue: cell.com/cell/current
News & Views: cell.com/cell/fulltext/S0092…
Daniel Podlesny retweeted
New preprint with @delafuenteupenn : The antimicrobial peptides (AMPs) of the global microbiome!
From 72 diffferent habitats (the best current sampling of the global microbiome) we obtained almost 1 million candidate AMPs
biorxiv.org/content/10.1101/…
Daniel Podlesny retweeted
Greengenes2 unifies microbial data in a single reference tree nature.com/articles/s41587-0…
Daniel Podlesny retweeted
1/ 🤰What can we learn about pregnancy form 45 million lab tests? We present a dynamic atlas of pregnancy and postpartum based on measurements from over half a million pregnancies at a one-week resolution. @biorxivpreprint @AlonBar10
Daniel Podlesny retweeted
This is awesome (new genetic code acting as a bidirectional firewall for infection and gene transfer) and a bit frightening (potentially higher fitness): I am glad they added a proper biocontainment (stable dependency on non-standard amino acid). nature.com/articles/s41586-0…
Daniel Podlesny retweeted
Our new @NatureMedicine study aims to improve our understanding of obesity & its impact on health. Although useful, classical BMI misclassifies ~30% of people. To capture the heterogeneity of obesity, we developed blood-omics-based biological BMI (bBMI). nature.com/articles/s41591-0…
Daniel Podlesny retweeted
Necrotizing enterocolitis (#NEC) is a devastating disease, affecting up to 11% of all very-low birthweight (<1500g) infants.
In our newest paper @Naturecomms we look at NEC prophylaxis regimens in clinics that are highly successful in preventing NEC (average NEC rate: 2.9%).
Daniel Podlesny retweeted
I am thrilled to share with you our recently published paper showing that the microbiota-derived metabolite 3-IAA influences chemotherapy efficacy in #PancreaticCancer @Nature
nature.com/articles/s41586-0…
Daniel Podlesny retweeted
Forget losing jobs to AI, look to the sky!
Flocks of pigeons detect cancer in scans with 99% accuracy & “are suitable surrogates for human observers in certain medical image perception studies, thus avoiding the need to recruit, pay & retain clinicians...”journals.plos.org/plosone/ar…
Daniel Podlesny retweeted
⚡️ On @NatureMedicine - Nivolumab plus ipilimumab with or without live bacterial supplementation in metastatic renal cell carcinoma: a randomized phase 1 trial
@montypal @NazliDizman #kidneycancer #immunotherapy
nature.com/articles/s41591-0…
Daniel Podlesny retweeted
Delighted to share our latest work on Bangladeshi infant gut #microbiome with Nestle Research, @icddr_b, @TheXavierLab 🙏Gut microbiomes of Bangladeshi infants harbored three successive Bifidobacterium longum clades 🦠 authors.elsevier.com/c/1g0K2…
