Watching the constant battle between hosts and pathogens in the lab and in my kids.

San Diego, CA
Joined February 2018
I am delighted to share the latest preprint from our lab, which was work that was conceived and led by @JTenthorey during her postdoc and during the first few months of her independent lab at UCSF. biorxiv.org/content/10.1101/… TL;DR: Indels matter. A lot. 1/
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New work from our @ASAP_Research team: nature.com/articles/s41594-0…. Parkinson’s disease-linked LRRK2’s closest relative, LRRK1 is tightly regulated via different mechanisms than LRRK2. Great collaboration with @aleschziner, @Daugherty_Lab, and Knapp labs
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Also, check out my episode of “Let’s Meet the Virologists” to learn a little about me and my career. Thanks to @lbthackray for having me on!
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With #ASV2023 only a few days away, this seems like a good time to resurface here on Twitter. Come hear all about my research with ⁦@Daugherty_Lab⁩ on Saturday in the Innate Immune workshop. Can’t wait to connect with my fellow virologists for the first time since 2016!
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Matt Daugherty retweeted
Innate immune #CARD8 mechanism for sensing #coronavirus & #picornavirus infection by detecting activity of #virus-encoded proteases; genetic variants in mammalian hosts affect which viruses can be sensed @BriBerryTea @psmitchej @Daugherty_Lab #PLOSBiology plos.io/43S8JZk
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Got a chance to share our story on a podcast with @Daugherty_Lab! Also my first time speaking on a podcast 🥳 Check it out here - open.spotify.com/episode/1NL…
Chinmay Kalluraya and Matthew Daugherty explain how vertebrates acquired a gene critical for vision from bacteria in the latest Science Sessions podcast: ow.ly/an8a50OurhW
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Matt Daugherty retweeted
Chinmay Kalluraya and Matthew Daugherty explain how vertebrates acquired a gene critical for vision from bacteria in the latest Science Sessions podcast: ow.ly/an8a50OurhW
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Matt Daugherty retweeted
Bacterial genetic origin in vertebrate eye evolution: @atnjoly recommends this @ChinmayK98 @Daugherty_Lab study in @PNASNews that finds interphotoreceptor retinoid-binding protein was inherited by horizontal gene transfer into the vertebrate genome facultyopinions.com/article/…
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A new study shows that IRBP, a protein necessary for vision in vertebrates, was acquired from bacteria over 500 million years ago. @Daugherty_Lab @ChinmayK98 @PNASNews article: ow.ly/B69l50NMksY @ScienceMagazine digest: ow.ly/9JJI50NMksZ
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Eye-opening origin story: Scientists traced the origin of a unique vision protein back 500 million years to bacteria. “It’s a massive shift because this is an entirely new piece of genetic material that’s been introduced from bacteria." - @Daugherty_Lab today.ucsd.edu/story/eye-ope…
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Matt Daugherty retweeted
For #SeeingDiversity we’re featuring @dalexstevens! As a grad student w @SamReckPeterson Alex focuses on using evolutionary guided approaches w the @Daugherty_Lab to uncover novel conflicts btw viruses & the host intracellular trafficking machinery, illustrated here by @GraceIHsu
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Replying to @dalexstevens
@dalexstevens in an awesome collaboration with Chris Beierschmitt in the @Daugherty_Lab shows that the dynein activating adaptor-NINL-plays a role in the interferon response to viral infections. Some viruses can “knock out” NINL through cleavage with their 3C or 3C-like proteases
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Matt Daugherty retweeted
I dessed as the Red Queen Hypothesis for Halloween this year. I was only missing a treadmill (so I could do all the running I could...)
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💥Our new paper just out @ScienceMagazine! Antiviral activity of a human protein of retroviral origin A study led fearlessly by @jofrank1088 We propose that the human genome encodes a deep pool of antiviral proteins derived from retroviruses! science.org/doi/10.1126/scie…
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Matt Daugherty retweeted
Thrilled to announce (on behalf of @HHMINEWS Hanna Gray Fellow @ArielleWoznica, who is too humble) the opening of the Woznica Lab at UT Austin in Jan! 🎉 Job openings (see woznicalab.com) for undergrads or techs interested in a cool model system and an amazing mentor.
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Matt Daugherty retweeted
Thrilled to announce two openings for tenure track faculty positions in the Department of Pathobiology @pennvet. Come join our vibrant, dynamic, innovative research community of outstanding colleagues and mentors. Apply here: apply.interfolio.com/115308.
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