David Goertsen retweeted
How do the ovary and the brain interact with each other? Eager to explore? Wish to find solutions for neuronal-related infertility? The Kahan lab is coming soon! PhD and MSc positions are open!
anatkahan.wixsite.com/kahan-…
I successfully defended my Ph.D. in Bioengineering last month! @Caltech has been an incredible place to do research and I'm thankful to have learnt so much there. 1/4
ALT Ph.D. defense title slide: "Expanding adeno-associated viral capsid engineering to multiple variable regions for diversified tropism"
I've received an incredible amount of support from my parents. They are both incredibly hardworking and have so much integrity - it was an easy template to follow to become a bioengineer. 3/4
ALT My parents, Janine and Gerald Goertsen, and I, in front of art in the Chen Institute for Neuroscience at Caltech.
My partner, @MaryIppolito6, was instrumental. She listened to me rehearse (several times), helped me edit, and made every moment fun. I'm lucky to have her with me in this process ❤️. 4/4
ALT Mary Ippolito and I posing in front of a mural in San Francisco.
David Goertsen retweeted
Excited to share my first post doc paper! W/ @Ravi__Nath @BrunetLab @KarlDeisseroth & Rahul!! Rapid and precise genome engineering in a naturally short-lived vertebrate doi.org/10.7554/eLife.80639
David Goertsen retweeted
Thrilled to finally share my work at @VivianGradinaru lab at @Caltech - we developed a spatial transcriptomics approach to visualize and quantitatively analyze pooled systemic AAVs (capsids and cargos) in intact tissue across species. 1/n
David Goertsen retweeted
Excited to share our latest work! 🎉
Individual-finger brain-computer interface decoding from posterior parietal cortex (PPC). #BCI finger representations resemble that of able-bodied individuals, even years after paralysis. elifesciences.org/articles/7…
#tweetprint 1/n:
David Goertsen retweeted
Now in @moltherapy Methods & Clinical Development (#MTMCD) from @Caltech researchers: Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the #AAV capsid. bit.ly/3c7XRBl
Can directed evolution of the #AAV capsid yield useful lung gene therapy vectors? My paper with @VivianGradinaru at @Caltech, out today in @MolTherapy – Methods and Clinical Development (cell.com/molecular-therapy-f…), aims to answer this question. 1/8
AAV9.452sub.LUNG1 expands the toolbox for gene delivery to the lung and demonstrates that productive vectors can be made through substitution between AA452-458 of the AAV9 capsid. We have shared the plasmid for AAV9.452sub.LUNG1 on @Addgene: addgene.org/184592/. 7/8
I am grateful for the support and mentorship of my advisor @VivianGradinaru and co-authors Nick Goeden and Nick Flytzanis (who both founded @CapsidaBio). I couldn't have done this project without them. 8/8
I'm excited to give the @driverseattalks tomorrow at 9am PST/12pm EST about our recent publication in Nature Neuroscience!
Back at it! Next week, we welcome David Goertsen (@DavidGoertsen) of the @VivianGradinaru Lab who will take us through his @NatureNeuro paper on engineering specific AAV capsid variants.
Join us on Tuesday 22-March-22 at 17:00h CET!
#OpenScience #ScienceTwitter #neuroscience
David Goertsen retweeted
Intravenous gene transfer throughout the brain of infant Old World primates using AAV biorxiv.org/cgi/content/shor… #bioRxiv
David Goertsen retweeted
Organ-specific targeting (enriched in brain, not liver) of adeno-associated virus (#AAV) capsids after intravenous delivery in mice and marmosets enables new avenues for gene therapy
New from @VivianGradinaru @DavidGoertsen @Caltech @CaltechN
go.nature.com/3lQCu9w