David Goertsen (@DavidGoertsen) profile picture

David Goertsen

@DavidGoertsen

Bioengineering Ph.D. @UBC & @Caltech alumni (he/him)

 Pasadena, CA
Joined January 2018
  • Tweets37
  • Following275
  • Followers178
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Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)Photo by David Goertsen (@DavidGoertsen)
David Goertsen retweeted
KahanLab (@anat_kahan) profile picture
KahanLab@anat_kahan21 Jun 2023
How do the ovary and the brain interact with each other? Eager to explore? Wish to find solutions for neuronal-related infertility? The Kahan lab is coming soon! PhD and MSc positions are open! anatkahan.wixsite.com/kahan-…

Anat Kahan lab | Brain-Ovary interaction

By investigating the brain-ovary interaction and utilizing genetic and optical tools, the Kahan lab aims to enhance fertility and improve overall female health.

anatkahan.wixsite.com
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Excited to share my first post doc paper! W/ @Ravi__Nath @BrunetLab @KarlDeisseroth & Rahul!! Rapid and precise genome engineering in a naturally short-lived vertebrate doi.org/10.7554/eLife.80639
Rapid and precise genome engineering in a naturally short-lived vertebrate

Rapid and precise genome engineering in a naturally short-lived vertebrate

Rapid and efficient CRISPR/Cas9-mediated knock-in of fluorescent reporters at various genomic loci enables cell- and tissue-specific expression and establishes the short-lived African killifish as a...

elifesciences.org
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David Goertsen retweeted
Min Jee Jang (@minjeejang) profile picture
Min Jee Jang@minjeejang29 Jan 2023
Thrilled to finally share my work at @VivianGradinaru lab at @Caltech - we developed a spatial transcriptomics approach to visualize and quantitatively analyze pooled systemic AAVs (capsids and cargos) in intact tissue across species. 1/n
Nature Biotechnology (@NatureBiotech) profile pictureNature Biotechnology
@NatureBiotech26 Jan 2023
Spatial transcriptomics for profiling the tropism of viral vectors in tissues go.nature.com/3Rd7NJZ
Image from Nature Biotechnology (@NatureBiotech)
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David Goertsen retweeted
Charles Guan (@charlesbmi) profile picture
Charles Guan@charlesbmi13 Oct 2022
Excited to share our latest work! 🎉 Individual-finger brain-computer interface decoding from posterior parietal cortex (PPC). #BCI finger representations resemble that of able-bodied individuals, even years after paralysis. elifesciences.org/articles/7… #tweetprint 1/n:
Stability of motor representations after paralysis

Stability of motor representations after paralysis

Neural populations in PPC dynamically represent motor-like and then sensory-like aspects of brain–computer interface finger movements with a representational structure that matches able-bodied...

elifesciences.org
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Now in @moltherapy Methods & Clinical Development (#MTMCD) from @Caltech researchers: Targeting the lung epithelium after intravenous delivery by directed evolution of underexplored sites on the #AAV capsid. bit.ly/3c7XRBl
Image from Molecular Therapy Family of Journals (@MolTherapy)
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David Goertsen retweeted
bioRxiv (@biorxivpreprint) profile picture
bioRxiv@biorxivpreprint11 Jan 2022
Intravenous gene transfer throughout the brain of infant Old World primates using AAV biorxiv.org/cgi/content/shor… #bioRxiv
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Organ-specific targeting (enriched in brain, not liver) of adeno-associated virus (#AAV) capsids after intravenous delivery in mice and marmosets enables new avenues for gene therapy New from @VivianGradinaru @DavidGoertsen @Caltech @CaltechN go.nature.com/3lQCu9w
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David Goertsen retweeted
Joanna W Jachowicz (@jwjach) profile picture
Joanna W Jachowicz@jwjach30 Oct 2021
Yay our work showing how Xist balances its specificity to chrX and robust gene silencing via SHARP spatial amplification mechanism is on biorxiv 😁❌❌😊 biorxiv.org/content/10.1101/…. And 🧵from @mitchguttman for details
Mitch Guttman (@mitchguttman) profile pictureMitch Guttman@mitchguttman30 Oct 2021
Why are lncRNAs lowly expressed? How can they regulate their more abundant targets? In our new preprint we explore how these features are balanced to ensure target specificity and robust gene regulation via a spatial amplification mechanism (biorxiv.org/content/10.1101/…)
Xist spatially amplifies SHARP recruitment to balance chromosome-wide silencing and specificity to...

Xist spatially amplifies SHARP recruitment to balance chromosome-wide silencing and specificity to...

Although thousands of lncRNAs are encoded in mammalian genomes, their mechanisms of action are largely uncharacterized because they are often expressed at significantly lower levels than their...

biorxiv.org
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David Goertsen retweeted
KahanLab (@anat_kahan) profile picture
KahanLab@anat_kahan30 Sep 2021
Happy to share our work from @VivianGradinaru lab. Great team work @AlonGreenbaum @minjeejang @ryanjhcho @xinhong_chen @PegahKF @Neuro_Elliott Daniel Wagenaar! Will be so happy to see you use it for your optical fiber and GRIN lens implants! cell.com/cell-reports/fullte…
Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-...

Light-guided sectioning for precise in situ localization and tissue interface analysis for brain-...

Kahan et al. describe a 3D histology method (LiGS) to investigate with high fidelity the vicinity of an intact optical implant (e.g., GRIN lenses and optical fibers). LiGS is compatible with immuno...

cell.com
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