Senior Editor @NatureSMB. Views and opinions are personal.
Joined May 2012
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Dimitris Typas retweeted
@mileshuseyin and the lab have put together a comprehensive protocol for genome-wide Micro-C and for Region Capture Micro-C (RCMC) in @NatureProtocols :
nature.com/articles/s41596-0…
See also the GitHub for a user-friendly end-to-end computational pipeline: github.com/ahansenlab/MicroC…
New Article! Mapping 3D genome organization at nucleosome-scale with Micro-C and Region Capture Micro-C (RCMC) dlvr.it/TTWNB5
Dimitris Typas retweeted
Happy to see our work on defining a dependency map of short linear motifs out. We use base editing screens to install more than 80000 mutations into SLiMs in more than 4000 proteins to determine their contribution to cell fitness. nature.com/articles/s41594-0…
Dimitris Typas retweeted
🔥 Chem(bio) friends, this one is big!!
IRB Barcelona is opening a Group Leader position in Chemical Biology! 💜
If your research plan and vision are at the interface of synthetic chemistry, chemical biology, and biomedicine, please check the call!
👉recruitment.irbbarcelona.org…
Dimitris Typas retweeted
Great to see our work featured in @NatureSMB! Thanks @DimitrisTypas for your coverage! @LabBoke @DexeusMujer
Dimitris Typas retweeted
In this Q&A with @NatureSMB, @RiceLaboratory and Yael David of @MSKCancerCenter comment on new work that advances the molecular understanding of and, potentially, the clinical arsenal against infection with Hepatitis B virus. #WorldHepatitisDay
nature.com/articles/s41594-0…
Dimitris Typas retweeted
New online! Q&A with Yael David and Charles Rice on using chromatin biology to understand hepatitis bit.ly/4nYQqwI
Dimitris Typas retweeted
Proud to share what we hope will be a reference study on human oocyte proteostasis. Young-donor eggs show globally reduced organelle activity vs. somatic cells, with an even steeper drop as they mature.
👇 for @zaffagg3 's detailed explanation
embopress.org/doi/full/10.10…
📣 Paper alert!! Excited to share the 2nd research paper from my time in the @LabBoke at @CRGenomica, out today in the @embojournal!
We asked: "how do human oocytes regulate proteostatic organelles under physiological conditions?"
We collaborated with @DexeusMujer and employed #healthy human oocytes freshly donated for heterologous IVF
1/
Dimitris Typas retweeted
A transcription balance required for genome stability 🧬⚖️
Our work on RNA Pol II transcription speed control by the DNA helicase RECQL5 and the transcription-coupled DNA repair complex is now on @NatureSMB
#CryoEM #transcription nature.com/articles/s41594-0…
Dimitris Typas retweeted
Please see our discovery of first-in-class BRISC deubiquitylating enzyme inhibitors rdcu.be/edRwF. A great journey with Elton Zeqiraj, Francesca Chandler, Joe Salvino. High-throughput screens, cryo-EM structure and ontarget activity to reduce inflammatory signals.
Dimitris Typas retweeted
What an absolute pleasure to have worked with the brilliant @SLorenzLab on this article, just out in @NatureSMB. We showcase interdisciplinary experimental approaches to investigate ubiquitination in the developing neuron -> 🧵
rdcu.be/d2miT
Dimitris Typas retweeted
Our November issue marks the launch of our new Series on best practices in microbiology.
We hope it acts as a 'living textbook' with an expanding collection of articles that push us towards better microbiology research.
nature.com/collections/fghae…
Our November Best Practices in Microbiology Focus issue is out featuring:
🦠A primer for SynComs
🌱Community standards & syncoms in plant-microbiome research
📋Clinical trial guidelines for pro- and prebiotics
🔎Our Series on Best Practices
Explore here nature.com/nmicrobiol/volume…
Dimitris Typas retweeted
Come join us as a postdoc in the JaJa lab at the Netherlands Cancer Institute if you are interested in the molecular mechanisms underlying telomere maintenance by ALT and in findings ways how to target ALT in pediatric cancer treatment.nki.nl/careers-study/vacanci…
Dimitris Typas retweeted
Nope 🤦♀️
In this week's new issue: What your brain's microbiome means for your health.
Grab a copy in shops now or download our digital editions. newscientist.com/issue/3510/
Dimitris Typas retweeted
We are hiring a lab manager. Deadline for application is the 13th of October. Apply here: candidate.hr-manager.net/App…
Dimitris Typas retweeted
📢 Job Posting
Are you looking for a new challenge in an outstanding scientific environment? We are #hiring a #Scientific #Manager! 👨🔬👩🔬
If you are passionate about science and enjoy working in an international collaborative environment, please apply now! 😊 @mpi_nat
You have a PhD in natural sciences or medicine? Organizing and communicating are your strengths? Then the open position of Scientific Manager at @schuhlab might be your perfect match! Find out more here👇
mpinat.mpg.de/29-24?c=250103…
Dimitris Typas retweeted
Thrilled to share that, together with my colleagues @UoDCeTPD and collaborators @Boehringer, we report @ScienceMagazine the breakthrough discovery and characterization of a small-molecule that degrades most oncogenic mutant forms of KRAS. 1/8 science.org/doi/10.1126/scie…
Dimitris Typas retweeted
Outstanding science and high spirits at CSHL Epigenetics & Chromatin meeting #cshlepich24 @berger_lab @NogalesLab @AnneF_S @Yael_David__ @Goodell_Lab @AsifaAkhtar1 @GAlmouzni Narlikar, Luger, Jabado
Dimitris Typas retweeted
We are thrilled to present you our work on BRCA1-BARD1 @Nature showing that the complex has a direct role in long-range DNA end resection. With @CeppiIlaria @DelloStritto_MR and our collaborators @PabloHuertasLab @SylvieNoorderm1 and Seidel labs.
nature.com/articles/s41586-0…
Dimitris Typas retweeted
Super excited to share that our paper is online now!🎊🥂
We uncover the fundamental mechanism of how BLM helicase deficiency drives rDNA instabily and compromises global genome integrity - a significant insight into the molecular basis of Bloom Syndrome. nature.com/articles/s41467-0…
Dimitris Typas retweeted
How do paternal genes contribute to post-fertilization development? A paper @nature identifies a sperm protein, which has no apparent effect on sperm development or fertilization, yet affects transcription of a maternal gene in early plant embryogenesis.
nature.com/articles/s41586-0…
