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Marvel held a drone show in Korea for ‘AVENGERS: DOOMSDAY’ that included a transition from Iron Man to Doctor Doom.
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An anti-diarrhea drug can kill aggressive brain cancer cells, new research reveals
A common over-the-counter anti-diarrhea drug could hold the key to triggering self-destruction in aggressive brain tumor cells.
In a compelling laboratory study, researchers from Goethe University Frankfurt discovered that loperamide—the active ingredient in over-the-counter anti-diarrhea medications like Imodium—can induce cell death in lab-grown glioblastoma cells.
Glioblastoma is an aggressive form of brain cancer notorious for resisting conventional treatments.
The team traced this anti-cancer effect to extreme stress placed upon the endoplasmic reticulum, an intracellular network responsible for protein manufacturing and folding.
While cancer cells typically utilize cellular recycling processes like autophagy to survive harsh conditions, the excessive stress induced by loperamide effectively flipped this survival mechanism into a lethal self-destruction routine.
The researchers determined that loperamide dramatically increases levels of ATF4, a key stress-response protein, which prompts the cell to engulf and digest large fragments of its own endoplasmic reticulum through a targeted process called reticulophagy. However, medical experts emphasize that this discovery does not mean taking loperamide can cure brain cancer.
Loperamide faces significant physical barriers to entering the brain, and taking high doses is extremely dangerous, posing risks of life-threatening heart rhythm disorders. Nevertheless, mapping this specific cellular stress pathway provides valuable guidance for scientists aiming to engineer novel, targeted glioblastoma therapies that safely exploit the same mechanism.
source: Meyer, N., et al. (2021). ATF4 links ER stress with reticulophagy in glioblastoma cells. Autophagy, 17(9), 2432-2448.
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*THE SUN WAS DARKENED. AN EMPEROR TREMBLED. AND A MAN FROM HEAVEN DIED.*
Nearly 2,000 years ago, during the very years in which Jesus Christ was crucified, something extraordinary was recorded in the imperial chronicles of China.
In AD 31, under Emperor Guangwu of the Han dynasty, the sun was eclipsed.
The ancient Chinese record declares:
“In the day of Gui Hai, the last day of the month, there was a solar eclipse. [The emperor] avoided the Throne Room, suspended all military activities and did not handle official business for five days.”
— History of the Later Han Dynasty, Chronicles of Emperor Guangwu, Year 7.
Imagine the scene.
The emperor of one of the greatest civilizations on earth, surrounded by his armies, ministers, and imperial splendour, was so shaken by the darkening of the heavens that he withdrew from his throne room.
For FIVE DAYS, the affairs of his empire were suspended.
He trembled before Heaven, confessing his own unworthiness.
Then came an astonishing imperial proclamation:
“Yin and Yang have mistakenly switched, and the sun and moon were eclipsed. The sins of all the people are now on one man. Pardon is proclaimed to all under heaven.”
— History of the Later Han Dynasty, Vol. 1.
Read those words again.
*The sins of all the people are now on one man.*
*Pardon is proclaimed to all under heaven.*
And there is something still more extraordinary.
An ancient omen text preserved in the Chinese historical commentary contains these amazing words:
“Eclipse on the day of Gui Hai, Man from Heaven died”.
— History of the Later Han, Astronomical Annals, No. 18.
Now turn your thoughts from China to Jerusalem.
There hangs the Lord Jesus Christ, the eternal Son of God, crucified beneath a darkened heaven.
From the sixth hour until the ninth, darkness covered the land.
The earth shook. The rocks were rent. The veil of the temple was torn in two.
And there, upon that accursed tree, the sins of God's elect were laid upon ONE MAN.
Not an earthly emperor trembling beneath Heaven's judgment, but the King of kings bearing divine judgment in the place of His people.
Not an imperial pardon issued by a frightened ruler, but everlasting forgiveness purchased by the precious blood of Christ.
What extraordinary words to find in the chronicles of ancient China during the very generation of the crucifixion!
Consider the sovereign providence of God.
He who appointed the hour of Christ's death also governs the sun, moon, and stars. Not one heavenly body moves without His decree. Not one emperor reigns independently of His will.
While the kings of the earth trembled beneath the heavens, the Lord of heaven and earth was accomplishing the redemption of His Church.
And the pardon purchased at Calvary would eventually be proclaimed throughout the nations, even to the distant shores of China.
*“The LORD hath laid on him the iniquity of us all.” — Isaiah 53:6.*
The heavens declare the glory of God.
And history itself unfolds according to His eternal decree.
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This is how you come back lookin’ after beefing with Sarah or Rolf from Ed, Edd and Eddy.
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Talk about an in-flight meal.
For the first time, researchers have captured rats hunting bats by grabbing them from the sky. Learn more: scim.ag/47WVwUd #ScienceMagArchives
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This is genuinely one of the funniest things I've ever seen. Fox News thought they were interviewing a Trump supporter, and this man went on national television to explain that he showed up just to witness the MAGA cult in its natural habitat. I'm crying laughing.
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🚨Update: If you have never prepared for a major emergency, has never prepped or gathered emergency supplies for a major disaster, you can go to the FEMA website for tips on how to start!
ready.gov
Readers added context they thought people might want to know
This account @defense_civil25 is not an official U.S. government or Homeland Security account. Official accounts are listed at dhs.gov/social-media-d… and the post links to official preparedness info at ready.gov.
dhs.gov/social-media-d…
ready.gov
fema.gov
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People seriously have a fantasy they will live in the lap of luxury and do absolutely nothing.
Labor is required for every position in life!
Know the price before you commit!
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this is so crazy. You can literally see from bottom to top when you’re in the hood versus when you exit the hood
Is The Cheesecake Factory Really a Restaurant for Regular Americans?
Here’s what the data show
washingtonsun.com/policy/che…
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🚨 THE PENTAGON’S DOOMSDAY PLAN: The Pentagon is preparing for a nightmare scenario—a global war that could knock out power grids, cripple supply chains and leave U.S. military bases cut off from essential services. ⚡️
@JenGriffinFNC breaks down the 90-day survival plan.
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BREAKING: Japan to urge all citizens to stockpile at least 3 days of food and water in preparation for major disasters and events, with an official emergency request set for November 2.
"At least three days, and I'd like to say a week if possible… please prepare food, toilets, and water properly at home even without public assistance," Japan's Disaster Management says.
It comes just 2 days after the Pentagon started to prepare every major US military base to operate for at least 90 days without outside electricity, fuel, water or supplies, anticipating a major war.
The UK launched the "Be Ready" program 5 days ago, also advising all citizens to keep 3 days of key supplies, including bottled water, non-perishable food, and a battery or wind-up FM radio.
Readers added context they thought people might want to know
Japan's call for citizens to stockpile at least 3 days of supplies is longstanding official advice for natural disasters like earthquakes and is tied to the scheduled November 2 launch of its new National Disaster Management Agency.
japantimes.co.jp/news/2026/09/2…
maff.go.jp/j/zyukyu/foods…
ibtimes.co.uk/japan-househol…
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Mike Tomlin ain’t fuckin around on TV. Absolutely LOVE how candid he is being. Industry went way too hard towards fluff - just afraid to piss people & sponsors off… but Tomlin is bringing REAL analysis back, where you are actually honest & upfront about the things you are saying & presenting
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POTENTIAL WARTIME DISRUPTIONS: The United States and Britain are separately preparing for disruptions that could leave military installations and households without essential services, as Western governments respond to potential wartime threats and risks to critical infrastructure.
The Pentagon is developing plans requiring major U.S. military bases to operate independently for at least 90 days if war or cyberattacks disrupt electricity, water, communications, and supply chains, according to a report.
Meanwhile, Britain is urging households to stockpile enough food, drinking water, and other emergency supplies to manage at least three days without essential services.
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Ex-FBI boss tells Americans to take warnings to stock up seriously: 'Get your stuff today' trib.al/wYDM6tz
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I fully understand why David prayed for God to create in him a clean heart and renew a right spirit within him. Sometimes, the greatest battle is not with the people around us but with what is happening inside us. You can have a good heart and still need God to work on your attitude, your thoughts, your reactions and the things you struggle to control.