If it’s infectious, I’m interested. I use evolutionary analyses to guide computational investigations of proteins from pathogens @CUBiosciences @AimlacCommunity
Caerdydd, Cymru
Joined June 2018
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Drew Mack retweeted
🚨🚨Job Alert🚨🚨
Developing a novel method for assessing global genetic diversity and molecular surveillance of Mycoplasma pneumoniae during its re-emergence after the COVID-19 pandemic and beyond.
@ESGMAC_escmid @ESGEM_ESCMID @ESGMD1
jobs.ac.uk/job/DHA175/resear…
Drew Mack retweeted
So the H5N1 virus that spilled over from cows to a human has acquired a mutation associated with mammalian adaptation.
This is what RNA viruses do when faced with a new host: adapt or die.
To prevent further adaptation, we need to stop further cross-species transmission.
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Drew Mack retweeted
This valedictory message is an outstanding piece of writing about life (from one very well lived) - something for everyone to read and reflect on. jerseyeveningpost.com/news/2…
Drew Mack retweeted
Every mutation that could exist, does exist. That has only been true for ~200 years. Most beneficial variants just haven't had the time to become ubiquitous. But now, at least 50 people in the world have every possible mutation in the human genome.
Drew Mack retweeted
Are you interested how #epistasis shapes the AMR evolution?
We showed that epistasis can be caused by independently modulating substrate binding and the chemical step ultimately changing the rate-limiting step in the catalytic cycle. @NatureCatalysis
nature.com/articles/s41929-0…
Drew Mack retweeted
Some of our thoughts regarding the clusters of pneumonia among children which was seen in China during November 2023.
Macrolide resistance is an issue in some regions which may impact on patient management and outcomes.
@PMeyerSauteur @ESGMAC_escmid
thelancet.com/journals/lanmi…
Drew Mack retweeted
Exciting times!
We have been awarded the ESCMID Study Group Collaboration Grant for 2024. These funds will support a new collaboration between @ESGMAC_escmid, @ESGEM_ESCMID & @ESGMD_escmid 1/4
Drew Mack retweeted
Exploring the Alternative Conformation of a Known Protein Structure Based on Contact Map Prediction
pubs.acs.org/doi/10.1021/acs…
#JCIM Vol64 Issue1 #Bioinformatics
Drew Mack retweeted
An anti-virulence drug targeting the evolvability protein Mfd protects against infections with antimicrobial resistant ESKAPE pathogens biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Drew Mack retweeted
Viroid-like colonists of human microbiomes biorxiv.org/cgi/content/shor… #biorxiv_micrbio
Drew Mack retweeted
Hypermutator lineages of Pseudomonas aeruginosa can emerge when the bacterium persists following acute infections such as ventilator-associated pneumonia; these lineages have the potential to affect patient outcomes. Learn more in #mSystems: asm.social/1ES
ALT Culture timeline and antibiotic MICs of P. aeruginosa isolates. Susceptible MICs are shown in green, intermediately susceptible MICs in yellow, and resistant MICs in red. Known antibiotic resistance genes containing non-synonymous mutations in the indicated isolates are shown to the right of the table. For reference, a timeline showing when each isolate was cultured is shown above the table (created with BioRender.com). The white background shading indicates lung isolates, and the orange background shading indicates blood isolates. Each MIC assay was performed a minimum of two times. * indicates the presence of multiple non-synonymous mutations.
Drew Mack retweeted
A tweetorial explainer on Puente-Lelievre et al (2023). We are very excited about this paper & its implications for phylogenetics. Here's why! (Work stems from @HFSP grant "How life got moving: reconstructing and re-evolving the bacterial flagellar motor" xitter.gq/SBSatEd/status/1380517…)
Tertiary-interaction characters enable fast, model-based structural phylogenetics beyond the twilight zone biorxiv.org/cgi/content/shor… #biorxiv_evobio
Drew Mack retweeted
Press release for a project very close to my heart - sequencing all of the koalas at San Diego zoo to work out heritability of koala retrovirus integrations that are predisposing them to cancer. illumina.com/company/news-ce…
Drew Mack retweeted
Bridgend Ravens are devastated to announce the passing of JPR Williams.
One of Bridgend's most decorated players and an icon of World rugby, JPR served the club most recently as Club President.
Our thoughts are with JPR's family and friends at this sad time 💙
🔵⚪
Drew Mack retweeted
Please, please will someone sample @amolrajan saying: "I can't accept Drum & Bass. We need Jungle, I'm afraid." 👊
Drew Mack retweeted
For any other future reviewers reading this, please don't take this as encouragement to trash me so I'll tweet it.
On further thought, as long as you score it well, bring it
Drew Mack retweeted
I really enjoyed speaking with @laubchad about the recent increase in Mycoplasma pneumoniae cases in China and Europe. A great opportunity to highlight the work of the @ESGMAC_escmid Mycoplasma pneumoniae Surveillence study co-led with @PMeyerSauteur @cardiffmet @CardiffMetRIS
Much like China, several European countries are seeing rising cases of mycoplasma pneumoniae, a bacterium that causes "walking pneumonia". How serious is it?
Read more: euronews.com/next/2023/12/05…
Drew Mack retweeted
We made a little conservation of amino acids tool, combining Weblogo and ColabFold, which you can run in the browser with a single sequence. Since some major conservation servers are down. Hope it's useful! rodrigueslab.com/resources @CRodriguesLab @pstansfeld @sokrypton
