🇯🇵群馬大学医学部附属病院 心エコーラボ。医師5人、超音波検査士４人という小規模ラボですが世界を目指しています。EFの保たれた心不全/HFpEFを対象とした臨床研究や運動負荷心エコーに力を入れています。心エコー/臨床研究/HFpEF/exercise hemodynamicsに興味のある仲間を募集中です📩
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ALT Kaplan–Meier curves for all-cause death or heart failure hospitalization in 970 patients with hypertension. The dashed curve shows patients with a hypertensive response to exercise (HRE), defined as the highest tertile of the systolic blood pressure rise relative to oxygen uptake (SBP/VO₂ slope). The solid curve shows the other two tertiles. Event-free survival was lower in the HRE group (log-rank χ² = 8.31, P = 0.004). Numbers at risk are shown below the plot at 0, 12, 24, 36, and 48 months. In a separate Cox analysis, a steeper SBP/VO₂ slope was associated with a higher hazard of the composite outcome (adjusted HR 1.13 per SD, 95% CI 1.05–1.20), accounting for age, sex, BMI, type 2 diabetes, established heart failure, peak SBP, and workload.
ALT Graphical Abstract. Hypertensive response to exercise (HRE) in patients with hypertension (AH) and preserved left ventricular ejection fraction (LVEF) identifies a phenotype characterized by advanced cardiopulmonary and vascular dysfunction. Radar plot variables were normalized to a 0–1 scale using the 5th–95th percentile of the cohort distribution. aaPWV: aortic arch pulse-wave velocity; AVO2diff: arteriovenous oxygen difference; ePCWP: estimated pulmonary capillary wedge pressure; LAVi: left atrial volume index; LVGLS: left ventricular global longitudinal strain; LVMi: left ventricular mass index; LUS: lung ultrasound; SBP: systolic blood pressure; SPAP: systolic pulmonary arterial pressure; SVR: systemic vascular resistance; TAC: total arterial compliance; TAPSE: tricuspid annular plane systolic excursion; VO2: oxygen consumption.
